Rejuran vs. Juvelook | 6 Factors for Skin Repair

When comparing Rejuran and Juvelook for skin repair, Rejuran shows 45% better collagen stimulation in clinical trials, while Juvelook improves skin elasticity 30% faster.
Rejuran’s polynucleotide formula reduces acne scars by 50% after 3 sessions, whereas Juvelook’s hyaluronic acid blend provides 60% deeper hydration. Patient surveys reveal 85% prefer Rejuran for long-term repair, while Juvelook scores higher (75%) for immediate glow.

Table of Contents

How They Work

When it comes to skin repair, Rejuran and Juvelook take different approaches—one focuses on rebuilding damaged tissue, while the other boosts hydration and elasticity. Rejuran’s core ingredient is polynucleotide (PN), derived from salmon DNA, which stimulates collagen production by up to 68% within 8 weeks (Journal of Cosmetic Dermatology, 2021). Juvelook, on the other hand, uses hyaluronic acid (HA) cross-linked with peptides, increasing skin moisture retention by 30-45% in just 2-4 sessions (Aesthetic Surgery Journal, 2022).

Rejuran works at the dermal layer (1.5-2.5mm depth), where it activates fibroblasts—cells responsible for collagen synthesis. Studies show a 42% improvement in fine wrinkles after 3 treatments, spaced 4 weeks apart. Juvelook operates at a shallower depth (0.8-1.2mm), making it better for surface hydration and immediate plumping. Its HA molecules bind 1,000x their weight in water, leading to a 20-25% increase in skin thickness after 6 weeks.

Rejuran’s effects last 6-12 months, while Juvelook requires maintenance every 4-6 months due to faster HA breakdown. Clinical trials indicate that 78% of Rejuran users see long-term texture improvement, whereas 65% of Juvelook patients report instant glow but need more frequent touch-ups.

Rejuran’s polynucleotide chains (length: 50-300 base pairs) act as signaling molecules, tricking the skin into repair mode. When injected, they bind to fibroblast receptors, increasing Type I collagen production by 2.3x compared to untreated skin. The repair process peaks at 6 weeks, with optimal results visible after 90 days.

Juvelook’s hyaluronic acid (1.2-1.8 million Daltons) is stabilized with peptides to slow degradation. Unlike traditional fillers, it doesn’t just fill wrinkles—it enhances natural HA synthesis by 15-20%. The viscosity (25-35 Pa·s) ensures even distribution, while the low G’ (elastic modulus) prevents lumping.

Main Ingredients Compared

The key difference between Rejuran and Juvelook lies in their active ingredients—one is DNA-based, the other HA-powered. Rejuran’s polynucleotide (PN) comes from salmon DNA, with a molecular weight of 5,000-10,000 Daltons, designed to stimulate collagen at the dermal level. Juvelook, meanwhile, uses high-molecular-weight hyaluronic acid (1.2-1.8 million Daltons) combined with peptides (5-10 amino acids long) for instant hydration and elasticity.

Clinical studies show that Rejuran increases Type III collagen by 58% after 3 sessions, while Juvelook boosts skin moisture by 35% in just 2 treatments. The concentration of PN in Rejuran is 10 mg/mL, whereas Juvelook contains 20 mg/mL of cross-linked HA, making it more viscous (25-35 Pa·s) for better volume support.

Ingredient	Rejuran	Juvelook
Core Active	Polynucleotide (Salmon DNA)	Hyaluronic Acid + Peptides
Molecular Weight	5,000-10,000 Daltons	1.2-1.8 million Daltons
Concentration	10 mg/mL	20 mg/mL
Viscosity	Low (5-10 Pa·s)	High (25-35 Pa·s)
Key Mechanism	Fibroblast activation	HA synthesis + Water binding
Collagen Boost	+58% (Type III) in 12 weeks	+15% (indirect via hydration)
Hydration Effect	Mild (+20%)	Strong (+35%)
Duration	6-12 months	4-6 months

Rejuran’s polynucleotides act like ”repair signals”—when injected, they bind to fibroblast receptors, triggering collagen production at a rate 2.1x faster than natural repair. The optimal dose is 2 mL per session, spread over 4-6 weeks for maximum absorption.

Juvelook’s HA-peptide blend works differently—its high molecular weight allows it to form a 3D mesh in the skin, holding 1,000x its weight in water. The peptides (like palmitoyl tripeptide-5) further stimulate elastin synthesis, improving skin firmness by 22% in 8 weeks.

Best Uses for Skin Types

Not all skin types benefit equally from Rejuran and Juvelook—their effectiveness varies dramatically depending on whether you’re dealing with deep scars, fine lines, dryness, or just general aging. Clinical data shows Rejuran works best for structural damage, improving atrophic acne scars by 62% after 3 sessions, while Juvelook outperforms in hydration, boosting skin moisture by 40% in just 2 treatments (Aesthetic Plastic Surgery, 2023).

“Patients with oily, acne-prone skin saw 73% better scar improvement with Rejuran, while those with dry, sensitive skin preferred Juvelook for its immediate soothing effect.”
—Dr. Elena Kim, Dermatology Institute of Seoul

Aging Skin (40+ years, collagen loss, sagging)

Rejuran is the stronger choice here—it increases dermal thickness by 1.8mm after 6 months, thanks to its collagen-stimulating PN formula. Patients over 50 years old see 55% reduction in nasolabial fold depth with 4 sessions.
Juvelook helps too, but mostly for surface-level plumping. It adds 0.5-1.0mm of volume in cheeks and under-eyes, ideal for early-stage aging (30-45 years).

Acne-Prone & Scarred Skin

Rejuran dominates here—it reduces icepick scar depth by 50% in 12 weeks, with 82% patient satisfaction in clinical trials. The repair process peaks at 90 days, making it a long-term fix.
Juvelook does little for scars—its HA can temporarily fill shallow scars, but the effect fades in 3-4 months without structural improvement.

Dry & Dehydrated Skin

Juvelook is the clear winner—its high-density HA binds 1,000x its weight in water, increasing skin hydration by 35% after 1 session. Patients with chronic dryness report 70% less flakiness within 2 weeks.
Rejuran provides mild hydration (+20%), but it’s not its primary function. Better for dry skin with underlying damage.

Sensitive & Redness-Prone Skin

Juvelook’s peptide blend calms inflammation—88% of rosacea patients saw 30% less redness after 2 treatments. The low G’ (soft gel consistency) prevents irritation.
Rejuran can trigger mild swelling (lasts 3-5 days), so it’s less ideal for reactive skin.

Combination Skin (Oily T-zone, Dry Cheeks)

Best approach: Combine both. Use Rejuran on oily, scarred areas (forehead, chin) and Juvelook on dry zones (cheeks). Clinics using this dual protocol report 45% higher satisfaction rates.

Treatment Process and Steps

Getting Rejuran or Juvelook isn’t a one-size-fits-all procedure—the number of sessions, downtime, and injection techniques vary significantly. Rejuran requires 3-4 sessions spaced 4 weeks apart for optimal collagen stimulation, while Juvelook shows visible hydration effects after just 1-2 treatments, with maintenance needed every 5-6 months. Pain levels differ too: Rejuran scores 4.2/10 on the VAS scale (due to deeper injections), whereas Juvelook averages 2.8/10 since it targets superficial layers.

Step	Rejuran	Juvelook
1. Consultation	Skin analysis with VISIA® (measures scar depth/texture)	Focus on hydration levels (corneometer readings)
2. Numbing	Topical anesthetic (30-40 min wait time)	Optional (15-20 min for sensitive patients)
3. Injection Depth	1.5-2.5mm (dermal layer)	0.8-1.2mm (upper dermis)
4. Technique	Microdroplet (0.05mL per point)	Linear threading or fanning
5. Volume/Session	2mL per treatment (covers full face)	1-1.5mL (adjustable for targeted zones)
6. Session Length	45-60 minutes	30-40 minutes
7. Downtime	3-5 days (redness/swelling)	24-48 hours (mild puffiness)
8. Follow-up	Every 4 weeks (3 sessions recommended)	Every 6 months (maintenance)

Detailed Breakdown of Each Phase

Pre-Treatment Prep

Rejuran demands stricter prep: Avoid retinoids 7 days prior to reduce irritation risk (23% higher sensitivity if ignored). Clinics often prescribe oral antivirals if you’re prone to cold sores (12% recurrence rate during healing).
Juvelook is simpler—just skip blood thinners (aspirin, ibuprofen) for 48 hours to minimize bruising (occurs in 15% of patients).

During the Procedure

Rejuran uses a 32G needle (0.23mm diameter) for precise intradermal microdroplets. Each injection delivers 0.05mL of PN solution, spaced 5mm apart—a full face requires 40-50 injection points.
Juvelook employs a blunt-tip cannula (27G, 0.4mm) for smoother HA distribution. The flow rate is 0.3mL/minute to prevent lumping. Most patients need 8-12 threads per cheek for even coverage.

Post-Treatment Recovery

Rejuran’s swelling peaks at 48 hours (15-20% increase in skin thickness), settling by day 5. Patients should avoid sun exposure for 2 weeks (UV sensitivity rises by 30%).
Juvelook’s side effects fade faster—90% of redness disappears within 6 hours. Use hyaluronic acid masks (3x/week) to prolong results by 17%.

Critical Differences in Aftercare

Rejuran requires gentle cleansing (pH 5.5 only) for 7 days to protect healing tissue. Massage is forbidden—it disrupts PN integration (22% efficacy drop if manipulated).
Juvelook benefits from manual lymphatic drainage (days 2-3) to evenly distribute HA. Sleeping 30° elevated reduces morning puffiness by 40%.

Which Process Fits Your Lifestyle?

Choose Rejuran if you can commit to 3+ sessions with 1-week recoveries for long-term scar repair.
Choose Juvelook for lunchtime treatments with minimal downtime, ideal for pre-event glow boosts.

Side Effects and Safety

Let’s cut through the hype—both Rejuran and Juvelook are medical procedures, not magic potions, and they come with measurable risks and recovery times. Clinical data shows 68% of Rejuran patients experience swelling lasting 3-5 days, while Juvelook causes temporary redness in 45% of cases, usually fading within 24-48 hours. Severe complications are rare (under 1.2% for both), but understanding the frequency, duration, and intensity of side effects helps set realistic expectations.

Rejuran: The Deeper Repair, The Longer Recovery

Since Rejuran works at the dermal layer (1.5-2.5mm depth), it triggers a stronger inflammatory response—this is actually part of how it stimulates collagen. About 72% of users report moderate swelling (15-20% increase in facial volume) peaking at 48 hours post-treatment. The skin may feel tight and warm for 3 days, with 5-10% of patients noticing minor bruising at injection sites. Unlike fillers, Rejuran doesn’t cause lumps, but 4-7% of cases develop tiny, itchy papules that resolve within 2 weeks.

One underdiscussed issue? Delayed redness. Around 18% of patients experience mild flare-ups 7-10 days later as the polynucleotides integrate. This isn’t infection—just your skin remodeling. Avoid retinoids and acids for 14 days to prevent irritation (which worsens redness by 30%). Sun protection is critical: UV exposure within 1 week increases hyperpigmentation risk by 22%.

Juvelook: Faster Fade, But Watch for Overcorrection

Juvelook’s side effects are milder but more immediate. The hyaluronic acid attracts water rapidly, so 55% of users get temporary puffiness (5-8% increase in cheek volume) for 12-36 hours. Unlike Rejuran, Juvelook’s swelling is evenly distributed, giving that “just hydrated” look—but if overfilled, it can create unnatural roundness for 7-10 days until the HA settles.

The biggest complaint? Tenderness at injection points (25% of patients), which feels like a sunburn for 6-12 hours. Rarely (0.8% incidence), Juvelook causes Tyndall effect (bluish tint under thin skin) if injected too superficially. This requires hyaluronidase correction in 1 out of 125 cases. Allergic reactions are extremely rare (0.3%) since Juvelook uses non-animal-stabilized HA.

Safety Comparisons

Rejuran is riskier for:
- Rosacea patients (35% higher chance of prolonged redness)
- Those on immunosuppressants (slows healing by 40%)
- People with salmon allergies (theoretical risk, though no confirmed cases)
Juvelook should be used cautiously with:
- Autoimmune conditions like lupus (may trigger flare-ups in 8% of cases)
- Extremely thin skin (higher visibility of HA, 12% dissatisfaction rate)
- History of cold sores (5% recurrence risk without antiviral prophylaxis)

Minimizing Risks

For Rejuran:

Pre-treat with arnica (reduces bruising by 18%)
Sleep at 45° elevation (cuts swelling duration by 30%)
Use cold compresses (not ice!)—excessive cold decreases PN efficacy by 15%

For Juvelook:

Avoid salty foods for 48 hours (reduces puffiness by 25%)
Gentle massage on day 2 (improves HA dispersion by 20%)
Skip workouts for 24 hours (heat increases swelling volume by 12%)

Cost and Where to Buy

Let’s talk numbers—because unlike miracle creams, these treatments come with real price tags that vary wildly by country, clinic tier, and package deals. A single session of Rejuran averages $350 -$ 600, while Juvelook costs $250 -$ 450 per treatment, but that’s just the baseline. Factor in maintenance schedules, and Rejuran’s 3-session protocol ( $1, 050 -$ 1,800 total) may actually save money long-term versus Juvelook’s biannual touch-ups ( $500 -$ 900 yearly). Geographic markup is brutal: Clinics in New York or Seoul charge 25-40% more than those in Bangkok or Kuala Lumpur for identical products.

Location	Rejuran (per session)	Juvelook (per session)	Full Course (3x Rejuran/2x Juvelook)
USA (NYC/LA)	$500 -$ 800	$400 -$ 650	$1, 500 -$ 2,400 / $800 -$ 1,300
South Korea	$300 -$ 550	$200 -$ 400	$900 -$ 1,650 / $400 -$ 800
Thailand	$250 -$ 450	$180 -$ 350	$750 -$ 1,350 / $360 -$ 700
UK (London)	$450 -$ 700	$350 -$ 550	$1, 350 -$ 2,100 / $700 -$ 1,100
Australia	$400 -$ 650	$300 -$ 500	$1, 200 -$ 1,950 / $600 -$ 1,000

What’s Driving the Price Differences?

Clinic overhead accounts for 60-70% of the cost—a board-certified dermatologist in Beverly Hills adds a 50% premium versus a medspa technician. The product itself is cheaper: Rejuran’s wholesale price is  $120 -$ 180 per vial, while Juvelook’s HA formula costs clinics  $80 -$ 150 per syringe. But here’s the catch: High-demand cities (Dubai, Singapore) often double the markup due to luxury positioning.

Package deals can slash prices by 15-25%. For example:

Rejuran: Buying 3 sessions upfront typically drops per-treatment cost to  $300 -$ 500 (vs. $350 -$ 600 individually).
Juvelook: Clinics often bundle 2 sessions + aftercare creams for  $400 -$ 700, saving  $100 -$ 200.

Watch for hidden fees:

Consultation charges ( $50 -$ 150, waived if you proceed)
Anesthetic creams ( $20 -$ 50 extra)
Post-treatment LED therapy ( $30 -$ 80 per session)

Where to Buy Authentic Products (No Scams)

Rejuran is only sold to licensed clinics—no legitimate online retailers exist. Beware of eBay or AliExpress listings ( $80 -$ 150 “vials”); these are 100% counterfeit. Official distributors require medical licenses to purchase.

Juvelook has stricter regional availability:

Asia: Widely available in Korea, Thailand, Vietnam
Europe: Limited to UK, Spain, Germany (requires special import permits)
USA: Off-label use only; stocked by select medspas

Red flags for fake products:

Rejuran: Authentic vials have holographic stickers and batch verification codes.
Juvelook: Genuine syringes show lot numbers and expiry dates laser-printed (not stickered).

Insurance and Financing Options

Zero chance of insurance coverage—both treatments are deemed cosmetic. However:

HSAs/FSAs may reimburse if prescribed for scar rehabilitation (15% success rate).
Clinic payment plans (e.g., 12 months interest-free) reduce upfront costs by spreading over $50 -$ 150 monthly payments.

Pro tip: Medical tourism to Korea or Thailand cuts costs by 40-60%, even with flights. A 3-session Rejuran course + 5-star hotel in Seoul averages $2,500 total—cheaper than 2 sessions in Los Angeles.