Rejuran Healing Process | 5 Steps for Optimal Results

The Rejuran Healing process involves five key steps for optimal results. First, a consultation assesses skin concerns. Next, the treatment area is cleansed and numbed. Then, the Rejuran polynucleotide solution is injected into the dermis using micro-needles, stimulating collagen production.

Patients may experience mild redness or swelling, which subsides in 24-48 hours. Clinical studies show 85% of users see improved skin texture within 2 weeks. For best results, 3-5 sessions spaced 4 weeks apart are recommended, with maintenance treatments every 6 months. Avoid sun exposure and strenuous activity for 48 hours post-treatment.

Table of Contents

Skin Prep Before Treatment

Prepping your skin before a Rejuran treatment isn’t just a suggestion—it’s a 25-30% factor in how well the product integrates and how quickly you see results. Studies show that patients who properly cleanse, exfoliate, and hydrate 3-5 days prior experience 40% less redness and 20% faster healing compared to those who skip prep.

The goal? Remove dead skin cells (which make up ~15% of the skin’s surface), balance oil production (optimal pH: 4.7-5.5), and strengthen the moisture barrier (hydration levels should be ≥12% on a corneometer). If your skin is dehydrated or irritated, Rejuran’s polynucleotide chains bind 50% less effectively, reducing collagen stimulation by up to 35%.

Start by avoiding sun exposure for at least 7 days—UV damage increases inflammation, slowing healing by 2-3 days. Use a broad-spectrum SPF 50+ (reapplied every 2 hours if outdoors) and a gentle cleanser (pH 5.0-5.5) twice daily. Harsh soaps (pH >9) strip lipids, raising transepidermal water loss (TEWL) by 30-45%, which delays recovery.

Exfoliation is critical but must be non-abrasive. Chemical exfoliants like 5-10% lactic acid (applied 2x/week) remove dead cells 3x more efficiently than scrubs, reducing clogged pores (comedone count drops by ~40%). Avoid retinoids and AHAs/BHAs 48 hours pre-treatment—they thin the stratum corneum, increasing penetration depth unpredictably (risk of 15-20% higher swelling).

Hydration is where most people fail. A hyaluronic acid serum (1-2% concentration) applied morning and night for 5 days pre-treatment boosts skin’s water content from ~8% to 12-15%, creating a plumper base for injections. Pair it with a ceramide moisturizer (3:1:1 ratio of ceramides:cholesterol:fatty acids) to reinforce the barrier—studies show this combo cuts post-treatment peeling by 60%.

Avoid blood-thinners (aspirin, ibuprofen, alcohol) for 72 hours—they increase bruising risk by 50% due to prolonged capillary bleeding (up to 25% longer clotting time). Instead, take arnica tablets (500mg, 2x/day) to reduce bruise severity by 30%.

Morning of the procedure, wash with a chlorhexidine-based cleanser (0.5-1% strength) to cut bacterial load by 90%, minimizing infection odds (<0.1% incidence). Skip makeup—foundation clogs 30-50% of microchannels created by needles, trapping bacteria.

Injection Steps Explained Simply

Getting Rejuran injections isn’t just about “poking and filling”—it’s a precision-driven process where technique impacts 60-70% of your final results. Studies show that when administered correctly, Rejuran’s polynucleotides stimulate 3x more collagen over 6-8 weeks compared to sloppy injections.

The key? Depth control (1.2-2.0mm for most facial areas), injection angle (30-45 degrees), and dispersion pattern (0.05-0.1mL per point) all affect how evenly the product integrates. Clinics using 31G-33G ultra-fine needles (diameter: 0.2-0.25mm) report 40% less bruising than those using thicker needles. And if the product is injected too fast (>0.1mL/sec), it causes 50% more swelling due to sudden tissue expansion.

First, your practitioner should mark injection points 5mm apart—this spacing ensures 95% coverage without overloading any single zone. Crowding injections (<3mm apart) leads to 25% higher risk of nodules (small lumps that take 2-3 extra weeks to dissolve). The skin is then disinfected with 70% isopropyl alcohol, reducing bacterial presence by 99.9% in 15 seconds.

The needle enters at that 30-45-degree angle—too shallow (<20°) and 40% of the product leaks out; too steep (>60°) and you risk hitting muscle, which increases pain by 3x. The ideal depth varies: 1.2-1.5mm for cheeks (where skin is 1.8-2.2mm thick), 1.8-2.0mm for nasolabial folds (thicker, 2.3-2.8mm skin), and 0.8-1.2mm for under-eyes (thin 0.6-1.0mm tissue). Go deeper than 2.5mm, and you waste product—15-20% ends up in fat layers, where it’s 50% less effective at collagen stimulation.

The injection speed matters just as much. 0.05mL per second is the sweet spot—faster than 0.1mL/sec causes 1.5x more swelling, while slower (<0.03mL/sec) leads to uneven distribution (30% patchy results). Practitioners often use a serial puncture technique (5-10 injections/cm²), depositing microdroplets that spread 2-3mm radially for uniform absorption.

Post-injection, immediate massage (5-10 seconds per zone) boosts dispersion by 20%, but pressing too hard (>300g of pressure) can force product into vessels, raising bruise risk by 35%. A cooling gel pack (-4°C to 0°C) applied for 3-5 minutes cuts swelling by 40% by constricting capillaries.

Pro tip: If you’re getting 2.0mL of Rejuran, expect 50-60 injection points for full-face treatment. Split into 3 sessions (0.6-0.7mL each, 4 weeks apart)? Collagen production peaks 18% higher than single-session dosing.

Common mistakes? Injecting into active acne (50% higher infection risk) or over-stretching skin during the procedure (causes 20% more microtears). And if the practitioner doesn’t wait 10-15 seconds after each injection (letting the product “settle”), 10-15% of it migrates before binding properly.

Aftercare Tips for Best Healing

Rejuran’s healing process isn’t passive—50% of your results depend on aftercare. Studies show patients who follow strict post-treatment protocols see 30% faster collagen regeneration and 40% less downtime compared to those who neglect it. The first 72 hours are critical: swelling peaks at 24-48 hours (up to 15% increase in facial volume), redness fades by Day 3-4, and micro-channels close within 6 hours (if undisturbed). Skip proper aftercare, and you risk 20-25% lower product efficacy, uneven texture (up to 50% more visible bumps), and prolonged irritation (7-10 days vs. 3-5).

Hour 0-6: Immediate Post-Treatment
Right after injections, your skin is 60% more permeable, meaning it absorbs—and loses—moisture 3x faster. Apply a hyaluronic acid serum (2% concentration) within 15 minutes to lock in hydration; this reduces transepidermal water loss (TEWL) by 35%. Avoid touching your face—bacterial transfer risk jumps 5x due to open microchannels.

Do This	Avoid This	Why It Matters
Use a sterile saline spray (0.9% NaCl) every 2 hours	Washing with tap water (pH 7.0-8.5, disrupts skin’s pH 5.5 balance)	Prevents 40% of irritation caused by impurities
Sleep on your back, head elevated 30°	Side-sleeping (increases 50% more pressure on treated areas)	Reduces swelling 20% faster by improving lymphatic drainage
Apply ice packs (4°C) for 5 mins/hour	Ice directly on skin (risks frostbite at <-2°C)	Cuts inflammation by 25% without damaging tissue

Day 1-3: The Repair Phase
Your skin’s barrier function is 50% weaker now. Use a ceramide cream (3:1:1 ratio) twice daily—this combo repairs lipids 2x faster than standard moisturizers. No makeup for 48 hours; foundations clog 30% of healing microchannels, trapping bacteria (infection odds rise to 1.5%).

Sun protection is non-negotiable. UV exposure doubles free radical damage in treated skin, slashing collagen production by 20%. Use SPF 50+ (zinc oxide 20%+), reapplied every 2 hours outdoors. Even 10 minutes of sun degrades Rejuran’s polynucleotides 15% faster.

Day 4-14: Collagen Activation
By Day 4, your skin starts producing new collagen at 3x the baseline rate. Boost this by:

Gentle cleansing (pH 5.5) 1x/day—overwashing (>2x/day) strips 25% of healing lipids.
Peptide serum (5% matrixyl) nightly—increases collagen density by 18% over 2 weeks.
No strenuous exercise for 7 days—increased blood flow extends swelling by 2-3 days.

Long-Term Maintenance
Rejuran’s effects last 6-9 months, but you can extend them:

Monthly microneedling (0.5mm depth) boosts results by 30% (stimulates same healing pathways).
Retinol (0.3-0.5%) after Week 4—increases collagen up to 40% more vs. Rejuran alone.

Red flags? Persistent redness (>7 days) signals 15% higher risk of PIH (post-inflammatory hyperpigmentation). See your provider if swelling worsens after Day 3 (possible granuloma formation in 0.3% of cases).

Expected Results and Timeline

Rejuran isn’t an overnight miracle—it’s a biologically timed collagen reboot. Clinical data shows 80% of users see the first visible changes at Day 14, but peak results take 6-8 weeks as new collagen matures. The process follows a fixed biological schedule: polynucleotides stimulate fibroblasts at 2x their normal activity, leading to a 35-50% increase in collagen density by Week 6. However, 10-15% of patients (usually those with skin thickness <1.8mm) see slower progress, needing 10-12 weeks for full effects.

The Rejuran Healing Timeline

Time Period	What’s Happening	Visible Changes	User Action Needed
Day 1-3	Acute inflammation phase: swelling peaks at 24h (↑15% volume), redness fades by 72h	Puffiness, slight tenderness	Ice 5min/hour, avoid touching, SPF 50+
Day 4-7	Fibroblast activation begins: collagen production ↑25%	Skin feels tighter, 20% reduction in fine lines	Start hyaluronic acid serum, no exfoliants
Week 2-4	Collagen synthesis accelerates: 1.5x baseline rate	30% improved texture, pores appear 15% smaller	Add peptide serum, avoid sun
Week 4-6	Mature collagen forms: dermal density ↑40%	Nasolabial folds 50% softer, acne scars 25% shallower	Introduce 0.3% retinol (if no irritation)
Month 3+	Full remodeling: collagen organizes into stronger Type I fibers (↑60% vs baseline)	Maximal lifting effect, elasticity 45% better	Maintenance microneedling (0.5mm)

Key Performance Metrics

Wrinkle depth: Reduces by 0.1-0.3mm (measured via 3D imaging) by Week 6.
Pore size: Shrinks 18-22% (from 0.12mm² to 0.09mm² on average).
Hydration: Skin water content jumps from 8% to 14% by Day 21.
Scar improvement: Atrophic acne scars fill in 20-30% (needs 2-3 sessions for >50% correction).

Variables That Affect Your Timeline

Age: Patients <35 see 20% faster results (fibroblast activity drops 1.5% per year after 30).
Skin type: Oily skin (sebum >150μg/cm²) may experience 10% slower absorption due to barrier interference.
Aftercare compliance: Skipping SPF delays healing by 5-7 days; proper hydration cuts downtime by 30%.

When to Worry

No changes by Week 3? Could signal low fibroblast response (5% of cases)—consult your provider.
Overcorrection (lumps): Rare (<1% incidence), usually resolves in 72h with massage.
Hyperpigmentation: Risk rises to 8% if exposed to UV within 14 days.

Longevity & Maintenance

Rejuran’s effects last 6-9 months but fade 20% faster in smokers or those with high UV exposure. To extend results:

Top-ups: A 0.5mL booster at Month 6 prolongs effects by 3-4 months.
Combination therapies: RF microneedling (1mm depth) at Month 4 boosts collagen another 25%.

Pro tip: Track progress with monthly VISIA scans—data shows users who monitor progress see 15% better outcomes (psychological reinforcement effect).

Common Questions Answered Clearly

Rejuran treatments spark 85+ questions per 100 patients—but only 20% get answered properly before injections. Confusion ranges from pain levels (actual score: 2.8/10) to why some see results in 10 days while others wait 4 weeks (hint: skin thickness under 1.5mm delays collagen response by 40%). Let’s cut through the noise with data-driven clarity, not marketing fluff.

“How many sessions do I really need?”
The 1-session wonder myth dies here. For moderate wrinkles (depth >0.2mm) or acne scars (volume loss >15%), 3 sessions spaced 4 weeks apart deliver 2.1x better collagen remodeling vs. a single treatment. But if you’re under 35 with minimal damage, 1-2 sessions maintain 80% of results for 9+ months.

“Patients asking for ‘just one vial’ see 50% less improvement than those committing to 2-3 treatments. Skin regeneration isn’t a vending machine—it’s a biological process requiring cumulative stimulus.”
—Dr. Elena Kim, Dermatologist (12-yr Rejuran practitioner)

”Why does my face look worse before better?”
Day 3 swelling peaks at 18% volume increase, mimicking “pillow face”—but this is critical for activation. The pressure triggers fibroblasts to produce 3x more collagen in the next 14 days. Redness lingering >5 days? Your skin’s repair cycle is 30% slower, likely due to low pre-treatment hydration (<10% water content).

”Can I mix Rejuran with filler/Botox?”
Yes, but not in the same syringe. Rejuran’s pH 7.3 clashes with hyaluronic acid fillers (pH 6.8-7.0), causing 15% faster degradation. Smart sequencing:

Botox first: Wait 72 hours before Rejuran to avoid 40% migration risk from muscle movement.
Filler after: Delay 2 weeks post-Rejuran—the new collagen strengthens filler support by 25%.

”What’s the #1 aftercare mistake?”
Sleeping sideways on Day 1-3. The 500g pressure from your cheek against a pillow displaces 20% of injected product into lymph vessels, wasting $150-200 worth of serum per night. Train yourself to sleep supine (back-down) using a 30° wedge pillow—this alone cuts bruising by 35%.

”Why do some clinics charge 2x more?”
It’s not greed—it’s needle physics. Clinics using 33G needles (0.2mm width) charge $50-80 more per session because:

40% less bruising (vs. standard 30G)
Precision dispersion (0.02mL error margin vs. 0.05mL)
25% longer needle lifespan (200+ injections before dulling)

Cheap places often reuse needles 3-5x, increasing infection odds to 1.8% (vs. 0.3% with sterile single-use).

”When will I see my final results?”
Mark your calendar:

Day 14: First glow (10% texture improvement)
Week 6: Peak collagen (50% density increase)
Month 3: Subtle “refinement phase” (pores shrink another 8%)

But smokers subtract 30% from these timelines—nicotine slashes fibroblast oxygen supply, delaying healing by 2-3 weeks.

”Can I exercise after?”
Heart rate >140bpm in the first 48 hours = bad news. Increased blood flow:

Dilutes 15% of Rejuran’s active ingredients
Triples swelling duration (from 3 days to 9)
Raises bruise risk from 10% to 45%

After Day 5, light yoga is safe. Wait 14 days for heavy lifting—that’s when 90% of microchannels fully seal.

Final reality check: Rejuran isn’t Photoshop. It’s science with a 6-week lag. Patients expecting instant perfection are 23% more likely to request unnecessary touch-ups. Trust the data—86% satisfaction kicks in at Week 8, not Day 3.