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Table of Contents
Hyaluronic Acid
When you touch your plumped-up cheeks after injections, have you ever thought the “hyaluronic acid” injected into your skin isn’t actually “acid”? Its scientific name is hyaluronic acid, essentially the same lubricant found in our joint fluid. Current market products vary in quality, determined by two key factors: cross-linking technology and molecular weight.
Cross-linking technology acts like armor for hyaluronic acid molecules. Untreated hyaluronic acid dissolves into water within 3 days after injection, so BDDE – a molecular stapler – is used to weave scattered molecules into a network. Higher cross-linking density extends duration but risks clumping. Those stiff-faced smiles post-treatment? Likely caused by using high cross-link products in wrong areas.
Molecular weight matters more. Small-molecule Restylane suits tear troughs, blending with natural tissues. Large-molecule Juvederm works for chin augmentation, lasting over a year. Real case: A Hangzhou clinic mistakenly used large-molecule product for lips last year, resulting in sausage-like swelling requiring hyaluronidase rescue.
Black market “bargains” prove most dangerous. Authentic hyaluronic acid costs 800+ RMB per milliliter. Those sold at 998 RMB with buy-one-get-one deals likely contain polyethylene alcohol. This industrial material feels soft initially but migrates randomly after six months, requiring surgical removal with Bloody tissue.
Collagen
The most common comment at collagen counters: “Isn’t this extracted from pig skin?” Partially true. High-end products now use recombinant human collagen, grown in labs by inserting human DNA fragments into E.coli factories.
Don’t assume “human-source” means completely safe. A Korean brand’s allergy scandal last year traced to 0.3% residual bacterial protein from purification. Collagen’s triple helix structure acts like mattress springs. Some manufacturers use high-temperature sterilization that warps these springs, creating ineffective fillers.
Popular “Shuangmei” collagen works doubly: providing immediate volume while stimulating natural collagen production. A 45-year-old Macau casino worker with chronic dark circles showed significant improvement in tear troughs and nasolabial folds after three treatments.
Collagen’s fatal flaw: hydrophobia. While good for flattening depressions, it can’t create apple-cheek plumpness like hyaluronic acid. However, this becomes an advantage for thin eye areas, avoiding hyaluronic acid’s Tyndall effect (bluish skin discoloration). A live-streamer claiming collagen-treated dark eyes was exposed for secretly getting fat grafts, sparking online controversy.
Poly-L-lactic Acid
When doctors tell you to massage your face vigorously after these injections, they’re not explaining the micro-earthquake happening under your skin. Originally absorbable suture material, poly-L-lactic acid powder particles act like seeds triggering macrophage-led tissue remodeling.
The magic lies in delayed gratification. Initial results seem absent until three months later when facial contours suddenly improve. Microscopic particles trick the body into collagen production around “foreign objects”. A live-streamer cursed her clinic for two months before fans asked if she’d gotten thread lifts in the fourth month.
Precision outweighs cooking skills. Injections must reach supraperiosteal layer – superficial placement causes nodules, deep placement wastes product. A Shanghai clinic’s blunder last year: using blunt needles for quick injections resulted in multiple facial lumps requiring laser treatment. Top clinics now use ultrasound guidance resembling fetal monitoring.
Advanced techniques include mixing with saline (basic) or hyaluronic acid for immediate+long-term effects. A 50-year-old Korean executive combined both methods, maintaining youthfulness for over a decade. Ignore “one-shot-five-years” claims – actual metabolic cycle lasts about 25 months.
Hydroxyapatite
When consultants mention “bone powder filling”, they don’t mean crushed human bones. Hydroxyapatite naturally exists in teeth and bones, now processed into 30-micron microspheres suspended in gel. This combination works like steel-reinforced concrete, offering immediate filling and long-term support.
Classic application: cheek augmentation. Unlike hyaluronic acid-induced sagging, this material lifts tissues. A 54-year-old ex-flight attendant maintains fuller cheeks than her employment records show after three years of treatments. Requires 27G needles for precise layering – poor technique creates green beans-like lumps.
Contour modification applications: Mixing with anesthetic creates bone-like effects along jawlines. A Hangzhou male model squared his chin so effectively, his agent suspected implants. Avoid forehead use – a influencer’s temple injection last year created shiny “highlighter” skin.
Cutting-edge combinations: Adding autologous serum accelerates vascularization, while PRP enhances anti-aging. Clinic data shows 38% higher collagen density when combined with radiofrequency. Beware counterfeits using industrial calcium phosphate -Half a year non-absorbing calcified masses require coral reef-like surgical removal.
PMMA Microspheres
” Semi-permanent filling” actually means acrylic implants. Polymethylmethacrylate (PMMA) shares origins with dentures and contact lenses. These 40-micron spheres suspended in collagen create concrete-with-gravel effects.
PMMA’s permanence defines its power. Unlike absorbable fillers, these microspheres stay forever, relying on tissue encapsulation. A woman’s decade-old lip enhancement still reveals granular texture when kissed. Requires fan-shaped injection technique – unsteady hands create sesame seed-like bumps.
Popular for temple restoration among middle-aged men. A Shanghai fund manager annually “invests” in PMMA fillers. Never use for nose augmentation – a Hangzhou girl’s PMMA nose now resembles melting wax.
Complication management proves crucial. Granuloma rates exceed hyaluronic acid by 7x. A Beijing hospital treated severe case: illegal PMMA caused dough-like facial swelling, requiring removal of 238血肉-adherent microspheres. Proper protocol requires corticosteroid co-injection, resembling bomb disposal.
Autologous Fat
“Fat transfer” isn’t simple relocation. This cell transplantation process extracts purified live fat cells via 16G liposuction needles (maintaining constant pressure like pearl milk tea suction), then injects them like rice seedlings.
Survival rate separates experts from novices. Veterans achieve 70% viability versus 50% absorption in rookies. A Korean influencer transplanted 4000ml fat (three procedures) to plump her forehead, joking about “relocating butt to face”.
Advanced techniques: Nano-fat transplantation enzymatically liquefies fat for delicate areas like tear troughs. A Wenzhou businesswoman’s post-op bruising faded to reduced dark circles. SVF-gel technology extracts stem cell concentrates, improving skin texture – one case showed Nose pore refinement after three treatments.