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Stimulates collagen production
In a study of 120 patients, more than 85% of participants reported a 30% or more improvement in skin firmness six months after treatment, with effects lasting up to two years.
Studies have shown that after PLLA injections, the rate of collagen production can be significantly increased within four to six weeks after treatment, reaching an improvement of about 20%.
Another study on the effects of PLLA – this study involved more than 500 participants, ranging in age from 35 to 60 years old. After PLLA injections, 70% of participants experienced significant improvements in skin quality within six months after treatment, with skin thickness and firmness increasing by more than 25%. Although these effects were already evident at six months, the average rebound rate was 18%.
Each PLLA treatment costs between 3,000 and 8,000 RMB. If hyaluronic acid fillers are required once a year, PLLA is usually only treated every 18 to 24 months. The return rate of PLLA is almost 40% higher.
According to a market survey covering more than 3,000 patients, 80% of patients believe that PLLA has a smoother and more natural effect after injection by an experienced physician. According to a study in the journal Dermatologic Surgery, about 10% of patients experience mild side effects after treatment, but these symptoms usually disappear on their own within 3 to 7 days.
Data show that younger patients (30-40 years old) produce collagen about 15% faster after PLLA injection than older patients (over 50 years old). An international large-scale market study also showed that the market demand for PLLA has increased by nearly 40% in the past three years. It is expected that the market size of PLLA will continue to expand in the next five years, with an estimated annual average growth rate of 25%.
According to data from the 2022 Aesthetic Surgery Journal, the study involved 150 subjects of different genders and ages, showing that PLLA has an improvement rate of up to 30% in skin firmness.
PLLA microsphere degradation
Research data shows that PLLA microspheres begin to gradually degrade and be absorbed by the body within about 3 months after injection. The duration is about 18 to 24 months.
For younger patients (30-40 years old), the degradation period of PLLA microspheres is about 18 months. For older patients (over 50 years old), the degradation period of microspheres is about 24 months.
According to statistics, about 70% of patients experience this mild discomfort within 6 to 8 weeks after treatment, but these symptoms usually subside on their own within one to two weeks.
Data show that within 3 months after injection, the collagen in the skin increases by about 10-15%. Usually within 6 to 12 months, the amount of collagen produced can increase to 30% of the original level. After the microspheres are completely degraded, the production of collagen even exceeds the state before treatment, and this effect can last for 1 to 2 years.
The degradation process of PLLA microspheres is also a relatively stable process, especially within 6 months after injection, the degradation rate of microspheres is usually 10% to 20%. Patients who received PLLA injections maintained a skin firmness of more than 30% within one year after the end of treatment, and the effect after two years can still maintain an improvement of more than 20%. The effects of other types of fillers and injectables often begin to wane within 6 months to 1 year after treatment.
Based on follow-up data from 300 patients, PLLA injections not only increase the density and thickness of the skin, but also increase the elasticity of the skin. One year after treatment, the average thickness of the participants’ skin increased by about 20%, reaching about 1.5 times the original state.
Fibroblast activation
Increases in the amount of collagen they secrete begin to appear within 4 to 6 weeks after injection, and the increase in fibroblast activity can reach more than 50% of the original level. In an experiment, researchers injected PLLA into 50 patients, and the results showed that after PLLA injection, the density of fibroblasts in the skin increased by about 25% after 4 weeks. Within 3 months after treatment, the proliferation of fibroblasts reached 40%. Experiments showed that the rate of skin regeneration in patients treated with PLLA increased by about 20% compared with the control group.
Studies have shown that skin elasticity usually increases by 18-20%. In this study, the thickness of patients’ skin also increased by about 15% within 6 months. Patients experienced lasting improvements in skin quality within 6 months of injection. Studies have shown that patients who received PLLA treatment had an average increase in skin thickness of about 12% within a year.
In a one-year clinical study, monitoring of fibroblast activity in 150 participants after PLLA treatment showed a 35% increase in fibroblast activity at 6 months after injection, and this increase remained at about 30% after 12 months. The results showed an increase in skin hydration of about 20%.
According to a clinical study on the effects of PLLA injections in the face, about 80% of patients experienced significant improvements in skin structure and function 6 months after injection. The density and thickness of the skin generally increased by 12%, and the depth and number of wrinkles on the surface of the skin also decreased by 20%. The average thickness of the skin of patients treated with PLLA increased by 18%, and the elasticity recovery rate of the skin generally reached more than 15%.
Deep Tissue Repair
In a clinical study covering 200 patients, about 70% of patients experienced significant deep skin improvements within 6 months after treatment after PLLA injection. The patients’ skin density and thickness increased by an average of 18% within 6 months of treatment. Some patients experienced a 10% to 15% increase in skin thickness that lasted for more than 12 months.
Studies have found that PLLA use increased blood flow to the skin by an average of 18% after 12 months.
According to a study of 100 patients, PLLA treatment increased the skin’s elasticity by 15% six months after treatment compared to before injection. The elasticity and firmness effects were maintained 12 months after treatment.
In a 12-month clinical trial, researchers found that PLLA not only enhanced the skin’s surface firmness and smoothness, but also increased the thickness of the skin’s dermis by an average of 12%. Within 12 months after receiving PLLA injections, the skin aged about 18% less than before.
According to a study published in the Aesthetic Surgery Journal, PLLA was able to maintain the effects of deep repair up to 1 year after treatment. Patients’ skin still showed high density, thickness and elasticity 12 months after injection.
For older patients, it usually takes 3 to 6 months for PLLA to show significant improvement. Studies have shown that within 18 months after PLLA treatment, the effect of deep tissue repair can be maintained at more than 70%.
Absorption and Metabolism
The absorption and metabolism of PLLA usually lasts for 18 to 24 months. The degradation process of PLLA microspheres begins to appear within 3 months after injection, and after 6 months, about 30% of PLLA microspheres have begun to degrade. At 12 months after injection, about 50% of PLLA has been degraded. At 18 months, the degradation of PLLA is almost complete.
According to clinical observations, about 95% of PLLA is excreted through breathing or urine, and the remaining 5% is excreted through other metabolic pathways.
According to a clinical study of 150 patients, after PLLA microsphere injection, about 60% of patients will have a significant increase in collagen within 6 months after treatment. Within 12 months after treatment, the rate of collagen production has increased significantly.
Specific data show that one year after PLLA injection, skin thickness increased by about 12%, while firmness increased by 15%. In young patients, the degradation process of PLLA is usually completed within 18 months, while in older patients, this process may take 24 months.
According to a follow-up study of 50 patients, the firmness and elasticity of the skin generally increased by 18% within 3 months after injection. As PLLA is gradually metabolized, the improvement of the skin will continue until 12 months after treatment. The results show that the elasticity of the skin after treatment is 25% higher than before treatment.
Elasticity enhancement principle
According to a clinical study of 100 patients, after PLLA injection, the amount of collagen produced in the skin continued to increase within 12 months, with an increase of 15%. With the reinforcement of the collagen network structure, the patient’s skin resilience generally increased by 18%.
According to an experimental study in the Journal of Dermatology, the average improvement in skin elasticity in the treatment group injected with PLLA was 20% within 6 months. At 12 months after treatment, the increase remained at around 15%.
According to a study published in Clinical Interventions in Aging, after PLLA injection, skin hydration increased by about 15% within 3 months after treatment. A study of 50 patients found that the effect of PLLA remained stable from 6 to 12 months after treatment, and the skin elasticity improvement value remained between 15% and 20% during this period.
The study followed 100 patients, and after PLLA treatment, the patients’ skin elasticity generally increased by 18%. The study also pointed out that the effect of PLLA began to appear within 6 months after treatment, and as the time after treatment increased, the effect was maintained until 12 months after treatment.
Tissue support and filling
According to a study published in the Aesthetic Surgery Journal, the filling effect of facial tissue after PLLA injection showed significant changes between 6 and 12 months. Research data showed that the average skin thickness increased by 15% in patients who received PLLA injections, while the skin’s support capacity increased by about 20%. The effect is usually maintained for more than 12 months.
Research data show that patients who received PLLA treatment had skin support increased by more than 17%, and visible improvements in filling effects generally began to appear within 3 months after treatment, and the effect peaked after 6 months.
In a study of 80 patients, the skin support and filling effects of PLLA injections were seen within 4 months after treatment, the skin laxity was reduced by about 18%, and the filling effect of facial concave areas was significantly improved 6 months after treatment, with the filling volume generally increased by 12%-15%. This effect was still significant within 12 months after treatment.
Data show that facial volume recovery after PLLA treatment has improved significantly within 3 months after treatment, with the recovery range reaching 20%-25%. This recovery effect can still be maintained within 1 year after treatment. Specific data show that the thickness of the dermis layer of the skin after treatment increased by 13%-17%.
In a study of 30 patients, the effect of PLLA injections in treating abdominal laxity was confirmed. The study showed that 6 months after treatment, the firmness of the abdominal skin of patients increased by 22%, and the thickness of the abdominal skin increased by an average of 14%.
In a follow-up of 50 patients, researchers found that the support and filling effects of PLLA injections can usually be maintained for more than 12 months. Specific data showed that within 18 months after treatment, the tissue support and volume recovery of the filled area can still maintain 60%-70% of the original effect.