Bonetta Deep — HENM Cross-Linked HA for Nasolabial Folds & Lip Volume (2 × 1.1mL)

Bonetta Deep is ExoCoBio’s mid-density workhorse — 24 mg/mL cross-linked hyaluronic acid + 0.3% lidocaine using patented HENM cross-linking technology. Supplied as 2 × 1.1 mL pre-filled syringes per box. Engineered for nasolabial folds, lip augmentation, and moderate facial contouring with 9–18 month durability. KFDA registered.

Bonetta Deep Cross-Linked HA Filler is manufactured by ExoCoBio Inc., a South Korea-based medical device and pharmaceutical company established in 2017. The product is part of the Bonetta dermal filler range, which is distributed across multiple international markets. Regulatory status: KFDA registered · GMP certified.

Bonetta Deep Cross-Linked HA Filler contains 24 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using ExoCoBio Inc.’s HENM Patented Cross-Linking technology. Phosphate-buffered saline at near-physiological pH carries the gel.

Per ExoCoBio Inc.’s clinical data, Bonetta Deep Cross-Linked HA Filler delivers 9–18 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Mid to deep dermis placement typically delivers the longer end of the duration range.

Bonetta Deep Cross-Linked HA Filler is engineered for mid to deep dermis placement. The standard recommended needle is 27G, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work.

Bonetta Deep Cross-Linked HA Filler regulatory status: KFDA registered · GMP certified. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use.

Store Bonetta Deep Cross-Linked HA Filler between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk.

No. Bonetta Deep Cross-Linked HA Filler uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation).

Yes — layered protocols combining different fillers are standard aesthetic practice. Bonetta Deep Cross-Linked HA Filler can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU.

HENM is ExoCoBio’s proprietary cross-linking process used across the Bonetta line. The technology produces a uniformly cross-linked HA gel structure with optimised viscoelasticity — allowing smooth extrusion through a fine needle while maintaining structural integrity post-injection. The result: even gel distribution, reduced risk of post-injection edema and bruising, and sustained shape retention over 9–18 months for the Deep variant.