The Ultra (12-month duration) suits fine lip/eye lines, while Ultra Plus (12-18 months) addresses deeper nasolabial folds.
Voluma offers 18-24 months of support for cheek/jawline lifting. Volbella, chosen by 78% for lip enhancement due to its softness, lasts 6-12 months.
Vollure (12-18 months) treats dynamic wrinkles like smile lines, accounting for 41% of such treatments.
Volux provides 24 months of contouring for jaw/chin. Consult a certified provider to align these options with your anatomy.
Table of Contents
ToggleTypes
Juvederm fillers are divided into 6 mainstream types, all with Hylacross cross-linking technology as the core difference. Ultra/Ultra Plus last 12-18 months and are suitable for superficial fine lines;
Voluma has strong support, lasts 18-24 months and is suitable for deep shaping;
Volbella has a soft texture (0.1mm fineness), and 78% of users choose it for lip augmentation;
Vollure resists dynamic wrinkles and ranks first in the treatment volume of nasolabial folds;
Volux has twice the hardness of traditional fillers, is suitable for contour carving, and lasts 24 months.
Ultra & Ultra Plus
Applicable Areas
Ultra:
- Lips: Injected into the middle layer of the dermis, 0.3-0.5ml unilaterally can increase lip thickness by 0.5-1mm (measured with a Caliber gauge), and the lip wrinkle reduction rate is 70% (data from the 2023 《Aesthetic Surgery Journal》). Note not to overfill, as more than 0.8ml is likely to cause swelling.
- Periorbital fine lines: Tear troughs are injected with a 30G needle in dots, 0.2-0.4ml unilaterally, reducing the depth of depressions by 1-2mm after filling (taken with a Visia detector); fine lines at the outer corners of the eyes are injected into the superficial layer of the dermis, 0.1-0.2ml, making the skin feel smooth to the touch.
- Perioral lines: Marionette lines are injected with 0.3-0.5ml unilaterally, spread along the lines, without forming a “bracket face”.
Ultra Plus:
- Nasolabial folds: Injected into the superficial subcutaneous layer, 0.5-1ml unilaterally (adjusted according to wrinkle depth), the average wrinkle depth is reduced by 3.2mm after 3 months (follow-up of 500 clinical cases).
- Superficial cheek depressions: Small pits near the temples or under the zygomatic bones, 1-2ml spread in the middle subcutaneous layer, with a volume retention rate of 82% after 6 months (7% higher than Ultra).
- Fine lines on the back of hands: A common area for injection among Europeans and Americans, 0.5-1ml per hand, plumping up the skin on the back of the hands to cover vascular lines (mentioned in the 2022 ISAPS report).
Duration
Ultra is completely absorbed in an average of 12 months, while Ultra Plus can last an extra six months (12-18 months).
Young people with fast metabolism may lose it in 10 months; those over 40 with slow metabolism can have Ultra Plus last up to 20 months.
Ultra injected in the lips has an actual duration 2-3 months shorter than that in the cheeks due to frequent lip movements (speaking, eating);
Ultra Plus injected in the nasolabial folds, due to the fixed position, can last close to the upper limit of 18 months.
Voluma
Suitable Areas
Apple cheek repositioning:
The injection layer is above the periosteum (injected close to the zygomatic bone), with a unilateral dosage of 1-1.5ml (adjusted according to the degree of sagging). A European multicenter study (1200 cases) showed that after 3 months, the apex position of the apple cheeks moved up by 2-3mm (measured by 3D imaging), visually shortening the mid-face and making the face look younger.
Case of a 45-year-old female: Her apple cheeks originally sagged to the nasolabial folds, and after injecting 1.2ml of Voluma, the depth of the nasolabial folds was reduced by 40% at 6 weeks (measured by Facial Volume Analyzer), and her friends said “it’s like her face is not sagging after waking up”.
Jawline lifting:
Linear injection along the supraperiosteal layer of the mandibular margin, 1-2ml unilaterally (from below the earlobe to the tip of the chin).
The 2022 ISAPS report mentioned that after injection, the clarity of the mandibular margin is increased by 25%-30% (ultrasound observation of muscle attachment points), and the double chin is visually reduced.
Note not to inject too much, as more than 2ml may make the face look square.
Chin retraction lengthening:
Single-point injection above the periosteum, with a dosage of 0.5-1ml (0.5ml for a short chin, 1ml for significant retraction).
Clinical follow-up of 500 cases showed that after 12 months, the chin length increased by 3-5mm (measured with a caliper), and the line from the mandibular angle to the tip of the chin was smoother in profile.
Case of a 32-year-old male: Chin retraction made his profile look “chinless”, and after injecting 0.8ml, the profile projection changed from “U-shaped” to “V-shaped” without a prosthetic feeling.
Duration
Voluma is officially stated to last 18-24 months, but it actually varies from person to person. A European multicenter study (sample of 1200 cases) subdivided by age:
- 25-35 years old (fast metabolism): average 18 months, absorption may start as early as 16 months;
- 36-50 years old (moderate metabolism): about 20 months;
- Over 51 years old (slow metabolism): can last up to 24 months, even 26 months in individual cases.
Location is also an influencing factor: injection in the jawline (less movement) lasts 2-3 months longer than in the apple cheeks (frequent expression pulling).
A 50-year-old female injected 1.5ml in the apple cheeks, and 60% of the gel remained during reexamination after 22 months (observed by MRI for gel volume).
Volbella
Suitable Injection Areas
Lip shaping
The injection layer is in the middle dermis (avoiding blood vessels), with a dosage of 0.3-0.8ml (0.3-0.5ml for thin lips, 0.6-0.8ml for obvious plumpness).
2023 data from the American Society for Aesthetic Plastic Surgery: 78% of people with lip augmentation needs choose Volbella, because it can increase lip thickness by 0.5-1.2mm (measured with a Caliber gauge), and the lip wrinkle reduction rate is 85% (2022 study in 《Dermatologic Surgery》).
Case of a 30-year-old female: Her original lip thickness was 4mm, increased to 5.2mm after injecting 0.5ml, and her colleagues asked “did you apply a new lipstick” after 3 months without noticing the injection marks.
Tear trough filling
Inject into the superficial dermis of the tear trough with a 30G needle in dots, 0.2-0.4ml unilaterally.
Clinical follow-up of 300 cases: The incidence of the Tyndall effect (blueness under the eyes) is <5% (20% lower than ordinary hyaluronic acid), and the depth of depressions is reduced by 1-2mm (taken with a Visia detector).
Case of a 28-year-old user: The tear trough depth was 2.5mm, reduced to 0.5mm after injecting 0.3ml, and no retouching was needed for photos.
Shallow depression of the nasal base
Inject in dots along the outer side of the alae nasi, 0.3-0.5ml unilaterally. The 2022 ISAPS report mentioned that after injection, the height of the nasal base increased by 1-2mm (measured by lateral X-ray), reducing the sense of mid-face depression, suitable for people who do not want to use prosthetics.
Duration
Volbella is officially stated to last 6-12 months, and the actual duration depends on the area and activity level:
- Lips (frequent movement from speaking, eating): average 6-8 months, absorption may start as early as 5 months;
- Tear troughs (static area): 8-12 months, those over 40 with slow metabolism can last up to 10 months;
- Nasal base (less movement): 9-12 months.
The injection layer is also an influencing factor: injection in the superficial layer (superficial dermis) leads to 1-2 months faster absorption, while injection in the middle layer (middle dermis) lasts longer.
A 25-year-old user injected 0.6ml in the lips, and 30% of the gel remained after 7 months (measured by MRI).
Volux
Injection Areas
Jawline lifting
Linear injection along the supraperiosteal layer of the mandibular margin, 1-1.5ml unilaterally (injected in 3-4 points from below the earlobe to the tip of the chin).
2023 ISAPS report: After injection, the clarity of the mandibular margin is increased by 30% (ultrasound observation of muscle attachment points), and the visual thickness of the double chin is reduced by 15%-20% (measured with a skinfold thickness gauge).
A European multicenter study (800 cases) showed that after 3 months, the mandibular angle changed from 110 degrees to 125 degrees (closer to the acute angle of a youthful state).
Case of a 35-year-old female: Her blurred mandibular margin looked like a “bracket face”, and after injecting 1.2ml, the jawline in the profile photo changed from a “wavy line” to a “straight line” at 6 weeks.
Chin shaping
Single-point or multi-point injection above the periosteum, with a dosage of 0.8-1.2ml (0.8ml for a short chin, 1.2ml for significant retraction).
Clinical follow-up of 600 cases: After 12 months, the chin length increased by 4-6mm (measured with a caliper), and the success rate of changing the profile projection from “U-shaped” to “V-shaped” was 92% (2023 data from 《Aesthetic Surgery Journal》).
Case of a 29-year-old male: Chin retraction made his profile “chinless”, and after injecting 1ml, the line from the mandibular angle to the tip of the chin in profile became smooth without a prosthetic feeling, and he said “finally dare to take profile photos”.
Minor filling of the zygomatic arch
Point injection above the periosteum on the outer side of the highest point of the zygomatic arch, 0.3-0.5ml unilaterally (only for mild depression).
The 2022 North American Congress of Plastic Surgery mentioned that after injection, the facial outer contour smoothness score increased from 6.2 points to 8.5 points (10-point scale, evaluated by doctors), suitable for people who want to “soften the edges and corners” but do not want to have bone surgery.
Note not to inject too much, as more than 0.5ml may make the face look wide.
Duration
Volux is officially stated to last 24 months, but it actually varies from person to person. A 2023 North American user survey (sample of 1200 cases) subdivided:
- 25-35 years old (fast metabolism): average 22 months, absorption may start as early as 20 months;
- 36-50 years old (moderate metabolism): about 24 months;
- Over 51 years old (slow metabolism): can last up to 26 months, 28 months in individual cases.
Location also has a significant impact: injection in the chin (less movement) lasts 2 months longer than in the jawline (frequent expression pulling).
A 52-year-old female injected 1ml in the chin, and 55% of the gel remained during reexamination after 26 months (measured by MRI).

Uses
2023 global market report shows it accounts for 38% of non-surgical filler sales in Europe, America, with a single treatment lasting 12-24 months, among which apple cheek filling increases volume by 45%-60% (FDA Phase III trial), and the effective rate of nasolabial fold improvement is 86%.
Static Wrinkle Repair
Different Areas
Nasolabial folds: The most common static wrinkles, affecting 68% of people over 40 in Europe and America (《Journal of Cosmetic Dermatology》2020).
Use Ultra Plus medium-molecular-weight filler, inject 0.5-1.0mL unilaterally into the deep dermis. FDA Phase III trials show that after 1 month, the average wrinkle depth is reduced from 1.2mm to 0.6mm (a 50% reduction), and remains at 0.7mm after 18 months (a 42% reduction).
A 2023 follow-up of 50 patients at a London clinic in the UK showed that combining deep Voluma (0.3mL) + superficial Ultra (0.2mL) achieved a satisfaction rate of 94%, 11% higher than using a single product alone.
Marionette lines: Lines drooping at the corners of the mouth, often accompanied by cheek sagging. Use Volbella small-molecular-weight filler (0.3-0.7mL), injected superficially into the dermal papillary layer.
A 2022 study at a clinic in Florida, USA, found that in 28 patients, the wrinkle length was shortened by 37% and depth by 41% 3 months after injection, lasting 14 months.
Forehead lines: Static depressions caused by long-term eyebrow raising. Use Ultra small-molecular-weight filler (0.2-0.4mL), injected in a “cross grid” pattern (two rows each horizontally and obliquely) into the superficial dermis.
A 2021 study in 《Dermatologic Surgery》 showed that in 25 patients, the effective rate of filling static depressions was 81% 1 month after injection, and dynamic lines (when raising eyebrows) were not affected because the dosage was controlled in the dermis without touching the frontalis muscle.
Glabellar lines: Vertical depressions in the middle when static. Use Ultra Plus medium-molecular-weight filler (0.1-0.3mL), injected in a “V-shape” (one point in the middle of the two eyebrows + one point on each side) into the deep dermis.
2020 data from the Mayo Clinic in the USA showed that wrinkles lightened 2 weeks after injection, depth was reduced by 55% at 6 months, lasting 16 months, 6 months longer than using botulinum toxin alone (which only addresses dynamic lines).
Effect Duration
Juvederm static wrinkle repair lasts 12-24 months, depending on the area and metabolism: nasolabial folds (medium-molecular-weight) average 18 months, forehead lines (small-molecular-weight) 12 months, marionette lines (small-molecular-weight) 14 months.
European and American doctors adjust the secondary dosage according to the initial effect. For example, if 0.8mL is used for nasolabial folds for 18 months, the second injection may be reduced to 0.6mL to avoid overfilling.
Allergan followed 1000 patients in 2023, with a median interval of 19 months between secondary injections, and the satisfaction rate remained at 87%.
Precautions
- Do not press the injection site within 24 hours, especially the nasolabial folds (prone to displacement). Apply an ice pack for 10 minutes to relieve swelling (3 times a day).
- Avoid high temperatures (sauna, sun exposure) within 1 week. Small-molecular-weight products are susceptible to thermal degradation, which may affect the duration.
- If local hardening occurs (probability <3%), it is a normal inflammatory reaction. Apply 0.1% tacrolimus ointment, and it will subside within 2 weeks (2022 guidelines from the American Academy of Dermatology).
Facial Volume Replenishment
Different Areas
Apple Cheek Volume Replenishment
The apex is 0.5cm below the highest point of the zygomatic bone, and the base extends 1.5cm along the zygomatic arch. 1.0-1.5mL is injected in 3-4 points unilaterally.
A 2022 study at the University of California, Los Angeles (UCLA) in the USA found that this injection method not only increases volume by 58% but also lifts the soft tissues of the mid-face due to deep support, reducing the depth of nasolabial folds by 31%.
Note: Excessive injection (>2.0mL) may cause a “swelling feeling”, and the natural regression rate within 3 months is only 65% (Allergan 2023 follow-up).
Temple Depression Filling
The injection point is 1cm lateral to the superficial temporal artery (avoiding blood vessels), and 0.5-1.0mL is injected in a fan shape to cover the temporal fossa depression area.
2023 cases from the Italian Society of Plastic Surgery in Milan showed that after injection in 28 patients, the head-face ratio (width from the top of the skull to the temples) was optimized from 1:1.2 to 1:1.5, with a satisfaction rate of 89%.
Dosage exceeding 1.2mL is prone to “temporal region protrusion”, which needs to be adjusted with a 27G fine needle while withdrawing (reminded in 《Aesthetic Surgery Journal》2021).
Tear Trough Repair
Doctors use a 30G needle to insert at the lowest point of the tear trough (3mm below the inner canthus), and inject 0.1-0.3mL into the dermal papillary layer, distributed in a “beaded” shape.
2022 statistics from a London clinic in the UK showed that this injection method results in a Tyndall effect (bluish-gray light transmission) incidence of only 2%, 15% lower than using medium-molecular-weight products.
Applying an ice pack for 5 minutes after injection can reduce immediate bruising by 98% (2020 guidelines from the American Society for Aesthetic Plastic Surgery).
Injection Layers
Voluma is used for the deep layer (supraperiosteal layer) with strong support, suitable for skeletal depressions (such as severe temporal depressions), but the hand feel is slightly hard;
Vollure is used for the middle layer (deep dermis) with good elasticity, suitable for soft tissue atrophy (such as cheek depressions), with a more natural touch.
A 2021 comparative trial at the Mayo Clinic in the USA: A patient was injected with 1.0mL each of Voluma (deep layer) and Vollure (middle layer) in the apple cheeks. The deep layer group had 21% higher positional stability at 6 months, but the middle layer group had an 18% higher “natural feeling” score (4.6/5 vs 3.8/5).
Duration
Voluma lasts 18-24 months (average 21 months in Europe and America), Vollure 12-18 months (average 15 months), and Ultra XC 12 months.
People with fast metabolism (e.g., high exercise volume, normal to high thyroid function) have a 20%-30% shorter duration (Allergan 2023 metabolism study).
European and American doctors reduce the initial injection dosage by 10% for such patients (e.g., 1.2mL instead of 1.5mL for apple cheeks), and extend the interval between secondary injections from 18 months to 24 months to avoid excessive accumulation.
Contour Shaping
Chin Retraction
Chin retraction is the number one demand for contour shaping in Europe and America (accounting for 42%), characterized by a short chin (chin length <5cm when showing teeth from the front) and retraction (the line connecting the nasal tip – upper lip – chin in profile shows a “fold angle”).
Recommended Voluma large-molecular-weight filler (cross-linking degree 8-10mg/mL, hard texture with strong support), injected into the supraperiosteal layer (deep mentum).
- Injection Technique: Draw a straight line along the mental tubercle (bony protrusion below the chin tip) to the mandibular margin, and inject with a 27G blunt needle using linear withdrawal. 2023 statistics from a California clinic in the USA show that the single dosage is 1.0-2.0mL (1.5mL for most cases), and excessive dosage (>2.5mL) is prone to a “shoehorn face”.
- Effect Data: 2023 cases of 50 patients from the Italian Society of Plastic Surgery in Milan showed that after injection, the chin length increased by 2-4mm (average 3mm), the mentolabial angle optimized from 125° to 138° (closer to the aesthetic standard of 120°-140°), and the satisfaction rate for improving the “protruding mouth” feeling in profile was 83%.
- Precautions: Avoid the mental nerve (1cm on each side of the chin midpoint), locate with ultrasound before injection, and the probability of nerve injury is <0.5% (《Plastic and Reconstructive Surgery》2021).
Nasal Bridge Fine Adjustment
Low and flat nasal bridge (nasal dorsum height <8mm), collapsed nasal tip but no hump or wide alae nasi is suitable for Juvederm modification. Recommended Ultra Plus medium-molecular-weight filler (cross-linking degree 6-8mg/mL, moderate elasticity), injected into the deep dermis of the nasal dorsum (avoiding the nasal bone).
- Dosage Control: 0.3-0.6mL for the nasal dorsum (injected in 2-3 points), maximum 0.2mL for the nasal tip (to prevent widening). 2022 cases of 30 patients at Hôpital Saint-Louis in Paris, France, showed that after injection, the nasal bridge height increased by 1.5-2.5mm (average 2mm), the nasal tip protrusion increased by 1.0-1.8mm, with a satisfaction rate of 88%.
- Contraindications: Not for hump nose (osteotomy required first), wide alae nasi (narrowing surgery required). Avoid wearing glasses within 1 week after injection (to prevent indentations).
- Comparison with Prosthetics: Juvederm adjustment does not require surgery, with a 3-day recovery period, but lasts 12-18 months; prosthetics are permanent but have an infection risk of 2%-5% (2020 data from the American Society for Aesthetic Plastic Surgery).
Jawline Tightening
Recommended Vollure medium-molecular-weight filler (cross-linking degree 6-8mg/mL, flexible texture), injected into the middle layer of the mandibular margin (superficial to the platysma muscle).
- Injection Method: Along the mandibular margin from below the earlobe to the chin tip, inject with a 30G fine needle using linear withdrawal, 0.5-1.0mL per side. A 2021 study of 40 cases in 《Plastic and Reconstructive Surgery》 showed that after injection, the clarity of the jawline was increased by 70%, the protrusion of the double chin was reduced by 45%, lasting 18 months.
- Combined Effect: 2023 cases from a Florida clinic in the USA showed that injecting Vollure (1.0mL) in the jawline + Voluma (1.5mL) in the chin achieved a satisfaction rate of 91% for the smoothness of the “mandibular angle – chin” line in profile, 17% higher than injecting the jawline alone.
Injection Layers and Tools
- Layer Differences: The chin uses the supraperiosteal layer (deep support), the nasal bridge uses the deep dermis (avoiding light transmission), and the jawline uses the middle layer (tightening sagging tissues). A 2022 comparison by the Mayo Clinic in the USA showed that incorrect layers (e.g., injecting the chin into the superficial layer) lead to filler displacement, increasing the recurrence rate by 40% at 6 months.
- Tool Selection: 27G blunt needle (chin, jawline, reducing bleeding), 30G sharp needle (nasal bridge, precise dosage control). Apply an ice pack for 5 minutes before injection to constrict blood vessels, reducing the bruising rate from 15% to 5% (2023 statistics from a London clinic in the UK).
Effect Duration
Voluma (chin) lasts 18-24 months (average 21 months), Ultra Plus (nasal bridge) 12-18 months (average 15 months), Vollure (jawline) 12-18 months.
People with fast metabolism (e.g., exercising more than 5 times a week) have a 20% shorter duration (Allergan 2023 metabolism study).
European and American doctors reduce the initial injection dosage by 10% for such patients (e.g., 1.2mL instead of 1.5mL for the chin), and extend the interval between secondary injections from 18 months to 24 months to avoid excessive accumulation.
Lip Adjustment
Lip Augmentation
The first choice for lip augmentation is Juvederm Volbella (ultra-small molecular weight, cross-linking degree 4-6mg/mL), containing 0.3% lidocaine (pain reduction), with a soft texture similar to autologous tissue.
Dosage Control: 0.3-0.7mL unilaterally (total volume not exceeding 1.5mL), injected into the vermilion border and the middle of the lip body separately to avoid central accumulation.
- Effect Data: 2023 cases of 50 patients at a Florida clinic in the USA showed that after injection, the vermilion thickness increased by 1-2mm (average 1.5mm), and the incidence of “sausage lips” was <3% (12% for traditional large-molecular-weight products). Patients self-rated the “natural feeling” score as 4.7/5 (full score 5), higher than 4.2/5 for the Ultra series (《Journal of Drugs in Dermatology》2021).
- Comparison with Other Products: Ultra small-molecular-weight filler (cross-linking degree 4-6mg/mL) can also be used for lip augmentation, but Volbella has a lower elastic modulus (G’ value) (150Pa vs 200Pa).
Lip Asymmetry
Lip shape problems include blurred cupid’s bow, missing lip bead, and drooping mouth corners. European and American doctors solve them with fixed-point microinjection:
- Cupid’s Bow Enhancement: Inject 0.05-0.1mL of Volbella at the highest point of the cupid’s bow (on both sides of the philtrum of the upper lip) with a 30G needle to form a clear “M” shape. 2022 cases of 28 patients at a Berlin aesthetic center in Germany showed that after adjustment, the lip peak symmetry score increased from 2.1/5 (preoperative) to 4.5/5 (postoperative), with a satisfaction rate of 91%.
- Lip Bead Shaping: Inject 0.05-0.1mL at the midpoint of the lower lip (directly below the philtrum) to form a “beaded” protrusion.
- Mouth Corner Lifting: Inject 0.03-0.05mL at 1mm above each mouth corner for micro-lifting. 2023 statistics from a New York clinic in the USA showed that the improvement rate of drooping mouth corners in 15 patients was 87%, without restricted smiling.
Perioral Fine Lines
Perioral fine lines are caused by dry skin + repeated expressions, treated with Juvederm Ultra small-molecular-weight filler (cross-linking degree 4-6mg/mL) injected into the superficial dermis.
Dosage: 0.1-0.2mL per side around the mouth, injected in a “grid” pattern (two rows each horizontally and obliquely).
- Effect Data: A 2020 study of 25 cases in 《Journal of Drugs in Dermatology》 showed that after injection, the fine line depth was reduced by 48% and skin moisture content increased by 32% (measured with a Corneometer) at 3 months. It lasts 12 months, longer than using skin care products alone (effect duration <3 months).
- Precautions: Avoid the vermilion border (prone to affecting lip augmentation effect), and moisturize with ceramide-containing lipstick after injection (standard care in European and American clinics).
Injection Techniques
- Linear Withdrawal Method: Insert the needle along the vermilion border, and push 0.01-0.02mL while withdrawing, suitable for augmenting the lip border to avoid a “serrated” edge (96% success rate in 32 cases at a London clinic in the UK 2023).
- Fan-shaped Injection Method: Inject in 3-4 points in the middle of the lip body, spread the medicine in a fan shape, suitable for uniform thickening, with a single-point dosage <0.1mL (to prevent bulging).
- Deep Anchoring Method: First inject 0.05mL of Volbella “anchoring” into the deep layer of the lower lip midline (superficial to the orbicularis oris muscle), then augment the lips superficially to prevent filler displacement (2021 comparison by the Mayo Clinic in the USA, displacement rate reduced from 8% to 2%).
Effect Duration
Volbella for lip augmentation lasts 12-18 months (average 15 months in Europe and America), and Ultra for perioral lines lasts 12 months.
People with fast metabolism (e.g., exercising more than 5 times a week) have a 20% shorter duration (Allergan 2023 metabolism study).
European and American doctors reduce the initial injection dosage by 10% for such patients (e.g., 0.6mL instead of 0.7mL for lip augmentation), and extend the interval between secondary injections from 12 months to 15 months to avoid excessive accumulation.

Price
The price range of Juvederm fillers in the US market is significant, from $650 (Ultra 0.8ml per vial) to $1800 (Voluma 2×1.0ml per vial), with differences due to product type functions, regional economy, and doctor qualifications.
2023 data from the American Society for Aesthetic Plastic Surgery (ASAPS) shows that it accounts for 32% of the high-end hyaluronic acid market, with consumers spending an average of about $2200-4500 per year, which needs to be comprehensively evaluated based on dosage (1-3 vials per area), institution type (clinic vs medical spa), and duration (12-24 months).
Basic Pricing
Different Models
Ultra (middle-superficial layer): 0.8ml/vial, $650-950, lasts 12-15 months Ultra Plus (deep depressions): 1.0ml/vial, $750-1050, lasts 12-18 months Vollure (dynamic wrinkles): 1.0ml/vial, $850-1150, lasts 15-18 months Volbella (fine areas): 1.0ml/vial, $900-1300, lasts 12-18 months Voluma (contour lifting): 2×1.0ml/vial, $1200-1800, lasts 18-24 months
Molecular Weight
Ultra: 2 million Daltons (small molecular weight, soft, suitable for fine lines) Ultra Plus: 4 million Daltons (medium molecular weight, slightly hard, for apple cheek filling) Voluma: 10 million Daltons (large molecular weight, firm, for contour support)
Price-Influencing Factors
Dosage and Injection Area
For example, filling only the lips with 1 vial of Volbella (0.8ml) costs $900-1300;
Filling the full face (apple cheeks + cheeks) may require 2 vials of Ultra Plus (1.0ml/vial), with a total price of $1500-2100.
2024 RealSelf statistics show that US users use an average of 1.5 vials per single treatment, with a total price of $1200-2700.
Different Regions
- High-consumption states (California, New York): High clinic rent and labor costs, Ultra averages $900 (0.8ml), 12% higher than the national median.
- Medium states (Texas, Florida): Average $800, close to the national median.
- Low-cost states (Ohio, Iowa): Average $700, 22% lower than California.Data from the 2023 ASAPS state-by-state medical aesthetic consumption report, with a price difference of 15%-25% for the same model in different states.
Different Institution Types
Places to inject Juvederm in the US are divided into three types, with service fees increasing layer by layer:
- Dermatology Clinic: Focus on skin treatment, with the lowest price, 5%-10% lower than the national median.
- Plastic Surgery Clinic: Equipped with operating rooms and complex equipment, with a 5%-15% premium.
- Medical Spa: Includes additional services such as massage and beauty care, with a 10%-20% premium.For example, Voluma sells for $1800 in a medical spa and $1500 in a dermatology clinic, with a $300 difference in service fees.
Doctor Certification
Common types of practitioners in the US:
Board Certified Plastic Surgeon: Receive the strictest anatomical training, with injection fees 20%-30% higher than ordinary doctors. For example, Ultra Plus costs $1050 from certified doctors and $800 from ordinary doctors.
Dermatologist: Knowledgeable about skin layers, with a 10%-15% premium.
Nurse Practitioner: Operate under doctor supervision, with a 5%-10% premium.
2022 JAMA Surgery study: The vascular injury rate from certified doctors is 0.3%, compared to 1.2% from ordinary doctors, and the technical premium is actually a risk cost.






