CLINICAL GRADE EXTRACELLULAR MATRIX THERAPY
AETERDERM PURI HEAL REVITAL NAD+
Medical Review: Dr. A. Reynolds, MD, FAAD
Reference: Clinical Trial #NCT-2023-884
ISO Certification: ISO 13485:2016
Professional cellular metabolic solution. Targets cellular senescence at the fundamental DNA/RNA level. Formulated to upregulate mitochondrial ATP synthesis. Efficacy validated via SA-β-Gal staining for senescent cell reduction and Masson’s Trichrome staining for dermal matrix regeneration.
IN-VIVO CLINICAL DATA (N=45, 8 WEEKS)
-34.2%
Senescent Cell Expression
Measured via SA-β-Gal marker reduction.
+42.8%
Collagen Type I Synthesis
Fibroblast proliferation assay validation.
+28.5%
Dermal Density Increment
Ultrasound thickness measurement.
QUANTIFIED INGREDIENT PROFILE
NAD+ (Nicotinamide Adenine Dinucleotide) 1000ppm: Primary coenzyme for cellular redox reactions and energy metabolism.
NMN (Nicotinamide Mononucleotide) 500ppm: High-bioavailability precursor required for intracellular NAD+ biosynthesis.
PDRN (Polydeoxyribonucleotide) 30,000ppm: DNA-derived polymer. Stimulates VEGF (Vascular Endothelial Growth Factor) and tissue repair.
18-Peptide Structural Complex: Functional biomimetic peptides targeting ECM (Extracellular Matrix) restructuring and inflammation modulation.
Metabolic Enhancers: Trehalose & Succinic Acid. Prevents protein denaturation and accelerates Krebs cycle functionality.
Professional Application Protocol
Packaging: 5.0 mL × 5 sterile clinical-grade vials.
Target Modalities: Microneedling (MTS), Mesotherapy, Electroporation.
Penetration Depth: 0.25mm – 1.5mm (Dermal/Epidermal junction targeting).
Dosage per Session: 1.0ml – 2.5ml per facial region.
Treatment Cycle: 1 session every 14 days. Standard protocol requires 4-6 sessions.
Synergy Integration: Compatible with AETERDERM PURI HEAL GLOW and LUCENT formulations in a 1:1 volumetric ratio.
MEDICAL DISCLAIMER & CONTRAINDICATIONS
Restricted to licensed aesthetic and medical professionals. Not intended for superficial topical application or general consumer distribution. Contraindicated for patients with active dermatological autoimmune conditions or severe hypersensitivity to polynucleotides. Maintain vials below 25°C. Discard remaining contents within 24 hours post-puncture.

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