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Profhilo 2ml

$117.00

Profhilo is an innovative injectable skin booster developed by IBSA Farmaceutici Italia S.r.l. (Lodi, Italy)—a leader in hyaluronic acid research. Unlike conventional fillers, Profhilo® uses the exclusive NAHYCO® Hybrid Technology and contains no chemical cross-linking agents (BDDE-FREE). Each 2 mL delivers 64 mg of pure hyaluronic acid (32 mg high molecular weight + 32 mg low molecular weight) to stimulate your skin’s natural production of 4 types of collagen and elastin—improving laxity, hydration, and elasticity from within.

⚠️ Not for sale to U.S. customers.

Quantity discounts
Quantity Discount Price
5-9 3% $113.49
10-19 5% $111.15
20-Unlimited 8% $107.64
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SKU: FF-PRFH-2ML Categories: ,
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Profhilo 2ml

HA Bioremodeler · 64 mg HA NAHYCO® Hybrid
Quick Answer
Profhilo 2 mL is IBSA's BDDE-free hybrid hyaluronic acid bioremodeler containing 64 mg of HA (32 mg high-MW + 32 mg low-MW) thermally stabilized via NAHYCO® technology. It targets skin laxity by stimulating four types of collagen and elastin — not by adding volume. Standard protocol is two sessions four weeks apart using the BAP 5-point technique.
Last Reviewed
May 19, 2026
Manufacturer specification cross-verified
Treatment Protocol
2 sessions, 4 weeks apart. Maintenance every 6 months.

Why This Skinbooster Is Different

Profhilo created its own category: bioremodeling. It is not a dermal filler (adds no volume) and not a classical skin booster (does more than hydrate). The combination of high-purity H-HA and L-HA in one stabilized complex enables both deep hydration and structural tightening from a single product.

Mechanism of Action

Bioremodeling (NAHYCO® thermal stabilization, BDDE-free). The hybrid cooperative HA complex disperses widely from a small number of injection points (5 BAP points per side), stimulating fibroblast and keratinocyte proliferation through low-MW HA binding to specific receptors, while the high-MW HA component provides scaffolding and slow-release hydration. Outcome includes four collagen types and elastin stimulation, beyond simple hydration.

Specifications

Product Name Profhilo 2ml
Category HA Bioremodeler
Active Ingredients 32 mg/mL Hybrid Cooperative HA (32 mg H-HA 1100–1400 kDa + 32 mg L-HA 80–100 kDa)
Mechanism Class Bioremodeling (NAHYCO® thermal stabilization, BDDE-free)
Manufacturer IBSA Farmaceutici Italia
Origin Italy (Lodi)
Pack 1 × 2 mL pre-filled syringe
Lidocaine Not included
Injection Technique BAP (Bio Aesthetic Points) — 5 fixed points per side at the malar/sub-malar zone
Injection Depth Deep subcutaneous, immediately above the periosteum
Recommended Needle 29G recommended (BAP technique)
Treatment Protocol 2 sessions, 4 weeks apart. Maintenance every 6 months.
Effect Duration ≈ 6 months after the initial 2-session course
Storage 2–25 °C, protect from light and freezing
Shelf Life 24 months unopened
Regulatory CE-marked Class III medical device. Manufactured under ISO 13485.
SKU FF-SB-PROFHILO-2ML

Clinical Indications

  • Skin laxity on the face, neck and décolletage
  • Loss of skin elasticity and firmness
  • Dehydrated, atonic mature skin
  • Off-face areas: hands, arms (inner), abdomen (Profhilo Body protocols)

Compare Within Skinbooster Category

Product Active(s) Mechanism Protocol Duration
Profhilo 2ml 64 mg HA NAHYCO® Hybrid Bioremodeling (NAHYCO® thermal stabilization, BDDE-free) 2 sessions, 4 weeks apart. Maintenance every 6 months. ≈ 6 months after the initial 2-session course
Restylane Skinboosters Vital Lidocaine 1ml 20 mg/mL NASHA HA + 0.3% Lidocaine Stabilized HA microinjection skinbooster (NASHA®, BDDE crosslinked) 3 initial sessions ~4 weeks apart. Maintenance every 4–6 months. Up to 6 months after initial 3-session course

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Frequently Asked Questions

Is Profhilo a dermal filler or a skin booster?
Neither in the traditional sense. IBSA classifies Profhilo as a 'bioremodeler' — it occupies a distinct category. Unlike fillers, it adds no structural volume; unlike pure skin boosters, it stimulates four types of collagen and elastin through hybrid HA action, producing visible tissue tightening alongside hydration.
How many sessions are needed and how often?
The standard manufacturer protocol is two sessions, four weeks apart. After the initial course, results last approximately 6 months. Maintenance treatments are typically administered every 6 months as a single session.
What is the BAP technique?
BAP (Bio Aesthetic Points) is the technique IBSA developed specifically for Profhilo. The practitioner injects 1 mL across 5 anatomically defined points per side of the face, depositing the gel in the deep subcutaneous layer. This standardised approach reduces bruising, controls diffusion and minimises injection trauma.
Does Profhilo contain BDDE or any cross-linker?
No. Profhilo uses IBSA's patented NAHYCO® thermal stabilization process, which bonds H-HA and L-HA through hybrid cooperative complexes without any chemical cross-linking agent. The formulation is BDDE-free.
Why are there two different molecular weights of HA?
The 32 mg of high-molecular-weight HA (1100–1400 kDa) provides sustained scaffold and tissue lifting through slow release. The 32 mg of low-molecular-weight HA (80–100 kDa) binds to specific receptors on fibroblasts and keratinocytes, triggering proliferation and deep hydration. The two MW pools act synergistically.
Can Profhilo be used on the neck and décolletage?
Yes. Profhilo H+L is widely used on the face, neck and décolletage. For the décolletage and hands, the manufacturer recommends adapting the BAP injection technique to the specific anatomy of those areas.
Is there lidocaine in Profhilo?
No. Profhilo H+L (the 2 mL formulation) does not contain lidocaine. Topical anaesthesia can be applied before treatment if patient preference dictates.
Can it be combined with botulinum toxin or other fillers?
Yes. Profhilo is frequently combined with botulinum toxin and traditional HA fillers as part of a comprehensive aesthetic plan. Treatments are usually staged — Profhilo is typically administered first or separately from same-day filler injections.
What downtime should patients expect?
Minor papules at the 5 BAP injection points are expected and usually resolve within 6–24 hours. Patients can normally return to social activity within a day. Bruising at the injection sites is uncommon when standard technique is observed.
Is Profhilo suitable for younger patients?
Yes, although the strongest indication is mature, lax skin. Younger patients seeking a preventive bioremodeling treatment may benefit, particularly for the perioral or jawline areas. Clinical judgement remains essential.
Regulatory Notice. CE-marked Class III medical device. Manufactured under ISO 13485. This product is manufactured outside the United States; FDA approval status is product-specific. For licensed healthcare professionals only. Practitioners are responsible for verifying regulatory status of this product in their jurisdiction before clinical use. Not for retail sale. Pricing subject to change.

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