Restylane Kysse — OBT Technology Lip Filler with Built-In Lidocaine

Unlike NASHA’s particle-based biphasic gel, OBT produces a single continuous monophasic structure. This integrates seamlessly with surrounding tissue rather than sitting as discrete particles — reducing the palpable “bolus” feel in dynamic facial zones.

OBT-technology fillers (Refyne, Defyne, Volyme, Kysse, Contour) are engineered to flex with facial movement. The gel maintains shape at rest but yields with smiling, speaking, and natural animation — preserving the patient’s expressive identity.

Manufactured by Q-Med AB in Uppsala, Sweden — the company that launched the world’s first HA dermal filler (Restylane, 1996). Over 40 million Restylane treatments performed globally across the NASHA and OBT product lines.

Stabilized hyaluronic acid at 20 mg/mL — the standard concentration across the Restylane portfolio. The HA is non-animal, produced by bacterial fermentation, and cross-linked using Galderma’s OBT Technology. Phosphate-buffered saline at pH 7 carries the gel.

Premixed local anaesthetic at the industry-standard 0.3% concentration. Reduces injection-site discomfort and eliminates the need for on-site mixing with separate lidocaine vials. The lidocaine itself wears off within hours of injection and does not affect long-term gel duration.

Lip Body Augmentation

Primary FDA indication. Restylane Kysse’s OBT gel structure delivers soft, kissable lip texture rather than the firm projection of NASHA technology. Patients report natural lip movement during smiling and speaking.

Lip Border Definition

Vermillion border definition without the rigid ‘duck lip’ projection that can occur with firmer fillers. The product integrates with native lip tissue for a defined but flexible border.

Upper Perioral Wrinkles

Smoker’s lines / lipstick lines above the upper lip — Restylane Kysse’s second FDA indication. Fine-cannula technique recommended for this delicate zone.

Cupid’s Bow Enhancement

Off-label refinement of the cupid’s bow shape. The OBT gel’s flexibility makes it well-suited to maintaining natural lip animation.

Brand & Origin

• Brand: Restylane (Galderma)
• Manufacturer: Q-Med AB
• Country of Origin: Uppsala, Sweden
• Audience: Licensed practitioners

Formula

• HA Source: Non-animal bacterial fermentation
• HA Concentration: 20 mg/mL stabilized
• Lidocaine: 3 mg/mL (0.3%) premixed
• Technology: OBT® Technology

Performance

• Duration: Up to 12 months
• Injection Depth: Lip body (submucosal), perioral dermis
• Recommended Needle: 30G ultra-thin wall typical
• Approval: FDA approved (lip augmentation + upper perioral wrinkles)

Packaging & Storage

• Packaging: 1 × 1 mL pre-filled syringe + needles
• Storage: 2–25 °C, do not freeze
• Shelf life: 24 months unopened
• Use: Single-use sterile

Restylane Kysse is a prescription medical device for use only by licensed aesthetic practitioners. Common reactions include injection-site bruising, swelling, redness, and tenderness — generally resolving within days. Like all hyaluronic acid dermal fillers, treatment carries rare but serious vascular complication risks. Mid-dermal placement reduces but does not eliminate vascular risk. Contraindicated in patients with severe allergies to gram-positive bacterial proteins. Full contraindications, vascular complication protocols, aftercare, and emergency guidance are detailed on the dermal filler safety page.