Chaeum Premium 1 — Monophasic HA Filler for Fine Wrinkles (1/4 Cross-Link Rate)

Chaeum Premium 1 is Hugel Pharma’s lightest monophasic HA filler — 24 mg/mL cross-linked hyaluronic acid + 0.3% lidocaine at the lowest cross-linking rate (1/4) in the Chaeum Premium series. Engineered for superficial-to-mid dermis placement. Endotoxin under 0.03 EU/mL, BDDE residual under 0.5 ppm. Supplied as 2 × 1.1 mL syringes per box.

Chaeum Premium 1 Hyaluronic Acid Filler is manufactured by Hugel Pharma Co. Ltd., a South Korea-based medical device and pharmaceutical company established in 2001. The product is part of the Chaeum dermal filler range, which is distributed across multiple international markets. Regulatory status: KFDA registered (3-2021-8521) · GMP certified.

Chaeum Premium 1 Hyaluronic Acid Filler contains 24 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using Hugel Pharma Co. Ltd.’s Monophasic Cross-Linking (1/4 Rate) technology. Phosphate-buffered saline at near-physiological pH carries the gel.

Per Hugel Pharma Co. Ltd.’s clinical data, Chaeum Premium 1 Hyaluronic Acid Filler delivers 6–9 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Superficial to mid dermis placement typically delivers the longer end of the duration range.

Chaeum Premium 1 Hyaluronic Acid Filler is engineered for superficial to mid dermis placement. The standard recommended needle is 30G, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work.

Chaeum Premium 1 Hyaluronic Acid Filler regulatory status: KFDA registered (3-2021-8521) · GMP certified. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use.

Store Chaeum Premium 1 Hyaluronic Acid Filler between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk.

No. Chaeum Premium 1 Hyaluronic Acid Filler uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation).

Yes — layered protocols combining different fillers are standard aesthetic practice. Chaeum Premium 1 Hyaluronic Acid Filler can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU.

Hugel Pharma rates the Chaeum Premium series on a 1-to-4 cross-linking scale, where Premium 1 has the lowest cross-link density and Premium 4 has the highest. Lower cross-linking produces a softer, more pliable gel suitable for superficial dermal placement (fine lines, delicate zones). Higher cross-linking produces a firmer gel for deep tissue placement (cheek augmentation, jawline contouring). All four Chaeum Premium variants share the same HA source and 0.3% lidocaine concentration — the cross-link rate is the variant differentiator.