Verified Medical Device Data | Class III | For Authorized Clinical Administration Only
Restylane® Kysse: Clinical Specifications
Injectable, cross-linked hyaluronic acid (HA) dermal filler engineered specifically for submucosal lip volumization and perioral rhytid correction.
Chemical Composition
• 20 mg/mL Cross-linked Hyaluronic Acid
• 3 mg/mL Lidocaine Hydrochloride
• Physiological Buffer pH 7.0
Package Integrity
• 1.0 mL Pre-filled Sterile Glass
• 2 × 30G 1/2″ Ultra-thin Wall
• GS1 Matrix Barcode for Traceability
Phase 3 Clinical Efficacy Data
Based on Galderma multi-center, randomized, evaluator-blinded controlled studies (N=270):
96% Cohort Satisfaction: Subjects reported observable lip fullness and structural improvement at 8 weeks post-injection.
78% Longevity Rate: Sustained volumetric retention maintained at 12 months.
20% Volume Efficiency: Achieved equivalent aesthetic endpoints utilizing 20% less product volume compared to non-XpresHAn baseline fillers.
Mechanism of Action: XpresHAn Technology™
Utilizes a proprietary manufacturing process adjusting the degree of cross-linking. This creates a flexible HA gel profile optimized for high-mobility perioral dynamic regions. The medium calibration particle size ensures tissue integration while mitigating the Tyndall effect in superficial submucosal planes.
Medical Safety Profile & Contraindications
Strict Administration Protocols
Must be administered exclusively by licensed medical practitioners holding formal training in facial anatomy and dermal filler injection techniques.
Absolute Contraindications:
• Documented history of severe allergic reactions (anaphylaxis).
• Known hypersensitivity to gram-positive bacterial proteins.
• Allergy to lidocaine or amide-type local anesthetics.
Documented Adverse Events (AEs):
Transient injection-site responses including erythema, edema, ecchymosis, induration, and pruritus. Mean resolution time for observed AEs is 3 to 7 days post-procedure without clinical intervention.

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