A Korean-made hybrid injectable that combines hyaluronic acid for immediate volume with poly-lactic acid (PLA) microparticles that prompt the skin to rebuild its own collagen — dual action in one vial.
What it is
Etrebelle 200 is a Korean-made hybrid injectable that pairs poly-lactic acid (PLA) microparticles, 170 mg, with non-crosslinked hyaluronic acid (sodium hyaluronate), 30 mg. The HA delivers immediate volume and acts as the carrier and lubricant for the PLA particles, while the PLA stimulates the skin to build its own collagen over time.
Common treatment areas
Practitioners use Etrebelle for facial volume loss and wrinkles — nasolabial folds, marionette lines, cheeks and temples — where a combination of immediate volume and gradual collagen rebuilding is wanted.
How it works
On injection the HA gives an instant softening and volumising effect; in the following weeks and months the biodegradable PLA microparticles prompt fibroblasts to lay down new collagen, so the correction transitions from physical HA support to the patient’s own newly synthesised tissue. Both components are fully resorbable.
How long it lasts
Because the lasting effect comes from newly formed collagen, results build gradually and are commonly reported to last up to about two years (≈18–24 months) before the materials are fully resorbed.
| Product type | PLA + HA hybrid collagen-stimulating injectable (biostimulator) |
|---|---|
| Composition | Poly-lactic acid (PLA) microparticles 170 mg + non-crosslinked hyaluronic acid (sodium hyaluronate) 30 mg per vial |
| Presentation | 1 vial of 200 mg per box (a separate 50 mg presentation also exists) |
| Reconstitution | Supplied as a powder; reconstitute with Sterile Water for Injection before use. The HA component shortens suspension time. Dilution volume and any anaesthetic are chosen by the practitioner per protocol. |
| Mechanism | Immediate volume from HA + gradual neocollagenesis from PLA microparticles; both biodegradable and bioresorbable (PLA metabolises to CO₂ and H₂O) |
| Duration of effect | Commonly reported up to ~2 years (≈18–24 months) |
| Administration | By licensed medical practitioners only |
| Country of origin | South Korea |
- Reconstitute. Add Sterile Water for Injection to the vial and allow the powder to hydrate into an even suspension; the HA content helps it suspend faster.
- Disperse fully. Confirm a homogeneous suspension with no aggregates before drawing up.
- Inject by plan. Place at the deep dermal or subcutaneous plane appropriate to the indication, using the cannula/needle and technique the injector is trained in.
- Schedule sessions. A course spaced several weeks apart is common, as the collagen-driven effect accrues over time.
What is Etrebelle made of?
Etrebelle 200 is a hybrid of poly-lactic acid (PLA) microparticles (170 mg) and non-crosslinked hyaluronic acid / sodium hyaluronate (30 mg) per vial. The HA carries and lubricates the PLA particles and gives immediate volume; the PLA stimulates collagen. Both are biodegradable.
How is it different from a pure HA filler or a pure PLLA stimulator?
A standard HA filler only adds volume that is later broken down; a pure PLLA stimulator builds collagen but gives no day-one volume and needs more reconstitution. Etrebelle combines both — instant HA volume plus gradual PLA collagen — and uses HA itself as the carrier instead of CMC, which makes for smoother injection and faster suspension.
How long do Etrebelle results last?
Because the durable effect comes from newly generated collagen, results develop gradually and are commonly reported to last up to about two years (roughly 18–24 months) before the materials fully resorb.
When will results be visible?
There is an immediate volumising effect from the HA on the day of treatment; the collagen-driven improvement then builds progressively over the following weeks and months.
Does Etrebelle need to be reconstituted?
Yes. It is supplied as a powder and is reconstituted with Sterile Water for Injection before use; the HA component helps it suspend more quickly. The exact dilution and any added anaesthetic are decided by the injector.
Is Etrebelle permanent?
No. It is temporary and fully bioresorbable — the PLA is gradually metabolised (to CO₂ and water) and the HA is broken down naturally, so the material does not remain in the body.
What is the difference between the 50 mg and 200 mg versions?
They are the same hybrid concept in different amounts of active material; the 200 mg vial carries more PLA+HA and is generally chosen for larger areas or greater correction, while the 50 mg suits smaller or more superficial work. Your practitioner selects the right one.
Who can administer Etrebelle?
Etrebelle is for administration by licensed medical practitioners only, using aseptic technique. It is not a consumer product and should never be self-injected.

Michael Reynolds –
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Jessica Thompson –
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