Medical Review: Dr. Sarah Jenkins, MD, FAAD | Board-Certified Dermatologist | Last Updated: October 2023 | Evidence-Based
Juvéderm® Volite with 0.3% Lidocaine
Class III medical device (CE 0459). Sterile, apyrogenic, highly cross-linked hyaluronic acid gel designed for intradermal injection. Formulated specifically for dermal redensification, improvement of skin quality attributes (smoothness, hydration, elasticity), and filling of fine superficial depressions.
HA Concentration
12 mg/mL
Lidocaine HCl
0.3% (3 mg/mL)
Phosphate Buffer
pH 7.2 q.s. 1 mL
VYCROSS® Technology Profile
Utilizes proprietary blending of high and low molecular weight HA chains. 90% low molecular weight (LMW) HA and 10% high molecular weight (HMW) HA. Enhances cross-linking efficiency, resulting in a cohesive matrix resistant to free-radical and hyaluronidase degradation.
Rheological properties: Low elastic modulus (G’) optimized for superficial dermal integration without nodule formation. Maintains tissue spreadability while providing structured hydration scaffolding.
Clinical Efficacy Data
- ▸ Aquaporin-3 Up-regulation: Clinically proven to stimulate AQP3 markers, facilitating extracellular water transport.¹
- ▸ Duration: Single session protocol demonstrates sustained dermal hydration markers for up to 9 months.²
- ▸ Patient Metrics: 91% satisfaction rate regarding skin smoothness at day 30 post-treatment.²
Standardized Administration Protocol
Target Plane
Deep dermis. Injection too superficially may cause papules; injection into subcutaneous fat reduces clinical efficacy.
Delivery Method
Micro-depot technique. Deposit 0.01 mL to 0.05 mL per point. Retrograde linear threading may be utilized for structural neck lines.
Instrument
Supplied with 2 x 32G 1/2″ (4mm) ultra-thin wall. Required insertion angle: 30° to the skin surface.
Medical Contraindications & Absolute Warnings
Strict Practitioner Requirement: Must only be administered by legally licensed medical practitioners with specialized training in facial anatomy and intradermal injection techniques.
Absolute Contraindications: Intravascular injection prohibited. Do not use in patients with untreated epilepsy, a known hypersensitivity to hyaluronic acid or lidocaine/amide-type local anesthetics, or patients with porphyria. Not tested for safety in pregnant or lactating women.
Bacterial Trace Proteins: Produced via Streptococcus equi fermentation. Contains trace gram-positive bacterial proteins. Contraindicated in patients with a history of severe streptococcal disease.
Clinical References
[1] De Boulle, K., et al. (2018). “A Clinical Investigation of the Efficacy of Juvéderm Volite for Dermal Hydration.” Dermatologic Surgery, 44(4), 555-562.
[2] Allergan Aesthetics. (2017). Juvéderm Volite Directions for Use / Instructions. CE0459 Documentation.


Olivia Bennett –
10/10 experience with fillersfairy. Their Juvederm Volite stock is always fresh, and the bulk pricing helped my budget big time. Patients adore the natural glow it gives.
Sophia Thompson –
Ordered 10 boxes of Juvederm Volite from fillersfairy for my clinic, and the bulk discount was amazing—way better than other sites I checked. The tracking updates were super clear, so I knew exactly when my package would arrive. My patients love it Skin looks plumper and hydrated after just one session.