Quick Answer
Kiara Reju by BioPlus Korea is a triple-active skinbooster combining hyaluronic acid 20 mg/mL with PDRN 5 mg/mL and niacinamide 1 mg/mL in a 2.2 mL pre-filled syringe. The PDRN drives fibroblast regeneration, HA delivers immediate hydration, and niacinamide adds anti-inflammatory and brightening effects. The combined matrix extends sustained benefit to up to 12 months — longer than typical PN+HA products.
Why This Skinbooster Is Different
Kiara Reju distinguishes itself with three notable features: (1) the high HA concentration of 20 mg/mL (matching dedicated HA boosters, much higher than typical PN+HA hybrids); (2) included niacinamide for anti-inflammatory and brightening support; (3) duration of up to 12 months per manufacturer data, exceeding standard PN+HA products. BioPlus is a specialized Korean biorevitalization manufacturer, not a general aesthetics company.
Mechanism of Action
PDRN + High-Conc HA + Niacinamide Triple-Active. Non-crosslinked hyaluronic acid is co-delivered with DOT™ polynucleotide and lidocaine. The HA component provides immediate hydration and acts as a delivery medium that improves PN distribution across the tissue field. The PN drives the underlying fibroblast-receptor-mediated regenerative cascade. Lidocaine reduces procedural discomfort across the multi-puncture mesotherapy technique without affecting the biological mechanism.
Frequently Asked Questions
What is Kiara Reju 2.2ml?
Kiara Reju is a Korean triple-active skinbooster from BioPlus Co., Ltd. — a 2.2 mL pre-filled syringe combining hyaluronic acid 20 mg/mL with PDRN 5 mg/mL and niacinamide 1 mg/mL. The product is positioned for combined hydration, regeneration, and tone correction in a single injection.
How is Kiara Reju different from Puri Hilo PN?
Both combine PDRN/PN with HA. Kiara Reju (BioPlus) is 2.2 mL with HA 20 mg/mL + PDRN 5 mg/mL + niacinamide 1 mg/mL. Puri Hilo PN (Aeterderm) is 2.5 mL with 25 mg PN total (~10 mg/mL) + dual-MW HA hybrid (HLD™). Kiara Reju has the higher HA dose and added niacinamide; Puri Hilo has the higher PN dose and the dual-MW HA architecture.
How is Kiara Reju different from Rejuran HB?
Both combine PN with HA. Rejuran HB (PharmaResearch Red Box) is 1 mL with DOT™-extracted PN + non-crosslinked HA + lidocaine. Kiara Reju (BioPlus) is 2.2 mL with PDRN 5 mg/mL + HA 20 mg/mL + niacinamide, no lidocaine. Different PN sources (wild Korean salmon DOT™ vs general salmon DNA), different additives, different volumes.
Why include niacinamide?
Niacinamide (Vitamin B3) has three roles in this matrix. (1) Anti-inflammatory — reduces post-injection erythema and inflammation. (2) Skin barrier function — increases ceramide synthesis. (3) Tone correction — reduces melanin transfer from melanocytes to keratinocytes, improving uneven pigmentation. The 1 mg/mL dose is sufficient for biological activity without irritation risk.
Why is the HA concentration so high (20 mg/mL)?
Most PN+HA hybrid products use lower HA concentrations (5–15 mg/mL) on the assumption that PDRN is the primary active. Kiara Reju's 20 mg/mL HA matches dedicated HA boosters, ensuring the hydration mechanism is fully engaged alongside the PDRN regeneration. The combination addresses immediate plumping (HA) and sustained dermal density (PDRN) at full intensity.
How long do results last?
Manufacturer data indicates up to 12 months sustained skin quality improvement after the initial 3-session course. This is notably longer than typical PN+HA hybrids (4–6 months). The longer duration likely reflects the higher HA concentration and the synergistic anti-inflammatory effect of niacinamide reducing tissue turnover.
What is the recommended injection technique?
30G/4mm needle for face, 32G for periocular area. Insert at 30° angle, advance to half the needle length (~2 mm depth in face), inject as micro-bolus, withdraw and reposition. Maintain 1 cm spacing between injection points. Each 2.2 mL syringe typically covers full face per session.
Where can Kiara Reju be injected?
Face, neck, décolletage. Periocular area can be treated with 32G ultrafine needles. The product is positioned for full-field biorevitalization. Avoid lips and intramuscular injection.
Is BioPlus the same company as JDBIO?
No — BioPlus Co., Ltd. is the manufacturer of Kiara Reju. JDBIO Co., Ltd. is one of the distributors that sells Kiara Reju globally. Other distributors include Maypharm, Estaderma, and various regional aesthetic suppliers. The product, packaging, and quality are consistent regardless of distributor.
How much does Kiara Reju 2.2ml cost?
Kiara Reju 2.2ml is priced at USD $52.50 per single syringe on Fillersfairy, with wholesale pricing for licensed practitioners. Larger pack sizes available on request.
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