Rejuran Tone-Up Booster 3+3

Name: Rejuran Tone-Up Booster 3+3 PDRN -- Dual Formula Skin Brightening & Repair 3x3 Kit
Brand: Rejuran
SKU: FF-REJR
Price: 152 USD
Availability: InStock
Rating: 5.0 (1 reviews)

Brightening Mesotherapy · c-PDRN + HA + brightening trio

Quick Answer

Rejuran Tone-Up Booster is PharmaResearch's brightening mesotherapy kit — a 2-vial system applied post-procedure. Vial 1 contains c-PDRN (DNA Optimizing Technology) at 1% with HA and panthenol for regeneration; Vial 2 contains ascorbic acid, glutathione, and tranexamic acid for melanin-pathway brightening. 3 sessions × 3+3 vials, 2 weeks apart. Designed for combined hyperpigmentation correction and skin regeneration.

Last Reviewed

May 19, 2026

Manufacturer specification cross-verified

Treatment Protocol

3 sessions, 2 weeks apart (one Vial 1 + Vial 2 pair per session). Maintenance every 3 months.

Why This Skinbooster Is Different

Tone-Up Booster is the brightening-specific product in the Rejuran ecosystem. Unlike Rejuran Healer, I, S, or HB (which are intradermal PN injectables), Tone-Up Booster is a topical post-procedure kit applied via microneedling channels. It combines PharmaResearch's c-PDRN regenerative platform with three established brightening agents — making it the most multi-target brightener in PharmaResearch's portfolio.

Mechanism of Action

Dual-Vial c-PDRN + Brightening Mesotherapy. Multi-target intervention on melanin biology: upstream signalling (α-MSH, endothelin) suppression, tyrosinase enzyme inhibition (rate-limiting step in melanin synthesis), melanosome maturation modulation, and melanosome-to-keratinocyte transfer regulation. Combined with the photoprotection regimen, established pigment is reduced and new pigment formation is limited.

Specifications

Product Name	Rejuran Tone-Up Booster 3+3
Category	Brightening Mesotherapy
Active Ingredients	Vial 1 (4 mL × 3): purified water + 1.0% hydrolyzed DNA (c-PDRN, DOT™ Technology) + sodium chloride + sodium hyaluronate + panthenol. Vial 2 (0.1 g × 3): purified water + sucrose + ascorbic acid + glutathione + tranexamic acid + sodium hydroxide + 1,2-hexanediol.
Mechanism Class	Dual-Vial c-PDRN + Brightening Mesotherapy
Manufacturer	PharmaResearch Bio Co., Ltd.
Origin	Republic of Korea
Pack	Vial 1: 4 mL × 3 (c-PDRN + HA solution). Vial 2: 0.1 g × 3 (brightening powder).
Lidocaine	Not included
Injection Technique	Topical application post-MTS, microneedling, or fractional laser — mix Vials 1 + 2 immediately before use and apply to treated skin
Injection Depth	Topical to superficial dermis via micro-channels (0.25–1 mm)
Recommended Needle	Microneedling, MTS, or fractional laser delivery (topical application post-procedure)
Treatment Protocol	3 sessions, 2 weeks apart (one Vial 1 + Vial 2 pair per session). Maintenance every 3 months.
Effect Duration	Visible brightening 4 weeks after course completion; sustained 4–6 months
Storage	2–25 °C, protect from light, do not freeze. Use immediately after mixing.
Shelf Life	36 months unopened (use within 1 day of opening)
Regulatory	Korean MFDS-registered cosmeceutical for topical/post-procedure use. Manufactured by PharmaResearch under KGMP. DOT™ (DNA Optimizing Technology) proprietary process for c-PDRN extraction.
SKU	FF-SB-REJURAN-TONEUP-3-3

Clinical Indications

Hyperpigmentation and melasma
Uneven skin tone and dullness
Post-inflammatory hyperpigmentation (PIH)
Post-laser brightening protocols
Photoaged and sun-damaged skin

Compare Within Skinbooster Category

Unique category on Fillersfairy: Rejuran Tone-Up Booster 3+3 is currently the only product in the Brightening Mesotherapy category on this site. Compare with adjacent skinbooster classes via the Related Products section below.

Frequently Asked Questions

What is Rejuran Tone-Up Booster 3+3?

Rejuran Tone-Up Booster is PharmaResearch's brightening mesotherapy kit — a 2-vial system with 3 sessions worth of product. Vial 1 (4 mL × 3) contains c-PDRN + HA + panthenol for regeneration; Vial 2 (0.1 g × 3) contains ascorbic acid + glutathione + tranexamic acid for brightening. The vials are mixed at point of care and applied post-laser, post-microneedling, or via MTS.

How is Tone-Up Booster different from Rejuran Healer or Rejuran I?

Rejuran Healer, I, S, and HB are intradermal injectables containing 2% PN for skin regeneration. Tone-Up Booster is a topical post-procedure kit with c-PDRN (1%) plus brightening agents (ascorbic acid, glutathione, tranexamic acid). Different mechanism, different application, different indication — Tone-Up is specifically for hyperpigmentation.

What is c-PDRN and how does it differ from PN?

c-PDRN is PharmaResearch's cellular polydeoxyribonucleotide produced via DOT™ (DNA Optimizing Technology). PN (polynucleotide) used in Rejuran injectables is longer-chain (500–5000 bp). c-PDRN is more processed and at a lower concentration (1% vs 2% PN), better suited for topical/microneedle absorption rather than direct injection.

How does the brightening mechanism work?

Three complementary actives target different melanin pathway steps. Ascorbic acid (Vitamin C) inhibits tyrosinase — the rate-limiting enzyme in melanin synthesis. Glutathione converts the eumelanin (dark) pathway to pheomelanin (light) and provides antioxidant protection. Tranexamic acid blocks UV-induced plasmin activity and reduces α-MSH signalling. Combined, they address upstream signalling, biosynthesis, and inflammatory pigmentation.

How is Tone-Up Booster applied?

Apply immediately after the in-clinic procedure (MTS, microneedling, or fractional laser). Mix Vial 1 (liquid) and Vial 2 (powder) — Vial 2 dissolves into Vial 1. Apply the mixed solution onto the treated skin, allowing absorption via the open microchannels. Use within 1 day of opening.

How many sessions are needed?

Standard course is 3 sessions spaced 2 weeks apart — exactly the amount in one 3+3 box. Visible brightening typically appears 4 weeks after course completion. Maintenance is every 3 months for sustained results. Severe hyperpigmentation may require an extended course of 5–6 sessions.

Can Tone-Up Booster be used standalone without microneedling or laser?

Manufacturer guidance is that the product is designed for post-procedure use — the microchannels created by MTS, microneedling, or laser are essential for active ingredient penetration. Topical application onto intact skin will not achieve the same penetration depth or clinical effect.

Is Tone-Up Booster safe for darker skin types (Fitzpatrick IV–VI)?

Yes — the brightening agents in Tone-Up Booster are well-tolerated across Fitzpatrick types. Patient selection still matters for the underlying procedure (MTS, microneedling, laser) — aggressive parameters in darker skin types can cause PIH that brightening alone cannot reverse. Conservative procedure settings combined with Tone-Up Booster work well across skin types.

How does it compare to Puri Heal Lucent?

Both are brightening mesotherapy products from Korea. Puri Heal Lucent by Aeterderm is intradermal injectable using PDRN + tranexamic acid + glutathione + tyrosinase inhibitors. Rejuran Tone-Up Booster is topical post-procedure with c-PDRN + similar brightening trio. Different delivery methods (injection vs topical-via-microchannels) — clinician preference and patient skin condition usually determine choice.

How much does Rejuran Tone-Up Booster 3+3 cost?

Rejuran Tone-Up Booster 3+3 is priced at USD $152.00 per kit on Fillersfairy. The kit contains 3 full sessions of Vial 1 + Vial 2 pairs.

Source verification:→ Korean MFDS (regulatory authority)

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Regulatory Notice. Korean MFDS-registered cosmeceutical for topical/post-procedure use. Manufactured by PharmaResearch under KGMP. DOT™ (DNA Optimizing Technology) proprietary process for c-PDRN extraction. This product is manufactured outside the United States; FDA approval status is product-specific. For licensed healthcare professionals only. Practitioners are responsible for verifying regulatory status of this product in their jurisdiction before clinical use. Not for retail sale. Pricing subject to change.

1 review for Rejuran Tone-Up Booster 3+3

Rated 5 out of 5

Dr. Linda K – May 14, 2026

The extrusion force needed for Ultra Ca is very consistent. Sometimes with these CaHA fillers, you get “clogs,” but the 2×0.8ml kit has a very smooth flow. I used it for a deep cheek augmentation. The way it mimics natural fat pads is impressive. One tip: make sure you’re injecting at the right depth, as this isn’t erasable like HA. But for those who know what they’re doing, the results are superior.

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