Side-By-Side
Regenovue Plus with Lidocaine vs Juvederm vs Restylane
| Feature |
Regenovue |
Juvederm (Allergan) |
Restylane (Galderma) |
| HA Concentration |
24 mg/mL |
15–24 mg/mL |
20 mg/mL |
| Cross-Linking Tech |
100% Cross-Linked HA |
Vycross / Hylacross |
NASHA® / OBT |
| Lidocaine |
0.3% (premixed) |
0.3% (XC lines) |
0.3% (Lidocaine variants) |
| Duration |
Up to 12 months |
6–24 months (varies) |
6–18 months (varies) |
| Origin |
South Korea (NeoGenesis Co. Ltd.) |
USA (Allergan / AbbVie) |
Sweden (Galderma) |
| Established Since |
2008 |
2006 |
1996 |
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Comparison based on manufacturer published data. See our top dermal filler comparison guide for broader market context.
FAQs
Regenovue Plus with Lidocaine — Frequently Asked Questions
What is Regenovue Plus with Lidocaine?
Regenovue Plus is NeoGenesis’s premium HA dermal filler — 24 mg/mL cross-linked hyaluronic acid + 0.3% lidocaine with 100% cross-linking between HA molecules for extended durability. Engineered as the lightest filler in NeoGenesis’s range for eliminating surface wrinkles on face and neck, including delicate eye-area lines. All ingredients fully biodegradable.
Where is Regenovue Plus with Lidocaine manufactured?
Regenovue Plus with Lidocaine is manufactured by NeoGenesis Co. Ltd., a South Korea-based medical device and pharmaceutical company established in 2008. The product is part of the Regenovue dermal filler range, which is distributed across multiple international markets. Regulatory status: CE marked · KFDA registered · GMP certified.
What is the HA concentration in Regenovue Plus with Lidocaine?
Regenovue Plus with Lidocaine contains 24 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using NeoGenesis Co. Ltd.’s 100% Cross-Linked HA with Biodegradable Matrix technology. Phosphate-buffered saline at near-physiological pH carries the gel.
How long do Regenovue Plus with Lidocaine results last?
Per NeoGenesis Co. Ltd.’s clinical data, Regenovue Plus with Lidocaine delivers Up to 12 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Mid to deep dermis placement typically delivers the longer end of the duration range.
What is the recommended injection depth for Regenovue Plus with Lidocaine?
Regenovue Plus with Lidocaine is engineered for mid to deep dermis placement. The standard recommended needle is 27G, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work.
Is Regenovue Plus with Lidocaine FDA approved or CE marked?
Regenovue Plus with Lidocaine regulatory status: CE marked · KFDA registered · GMP certified. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use.
How should Regenovue Plus with Lidocaine be stored at the clinic?
Store Regenovue Plus with Lidocaine between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk.
Does Regenovue Plus with Lidocaine contain animal-derived ingredients?
No. Regenovue Plus with Lidocaine uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation).
Can Regenovue Plus with Lidocaine be combined with other dermal fillers in the same session?
Yes — layered protocols combining different fillers are standard aesthetic practice. Regenovue Plus with Lidocaine can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU.
What does ‘100% cross-linked’ mean in Regenovue Plus?
NeoGenesis’s ‘100% cross-linked’ designation indicates that essentially all HA molecules in Regenovue Plus are bound to BDDE cross-linkers during the manufacturing process — leaving no significant free (non-cross-linked) HA in the gel. The result is enhanced enzyme resistance (HA-degrading hyaluronidase enzymes work more slowly on fully cross-linked HA), supporting the 12-month durability claim. The biodegradable ingredients ensure the body naturally eliminates the filler over time without permanent residues, making Regenovue Plus a safe choice for first-time filler patients seeking longer durability than non-cross-linked products.
Important Safety Information
Read Before Clinical Use
Regenovue Plus with Lidocaine is a prescription medical device for use only by licensed aesthetic practitioners. Common reactions include injection-site bruising, swelling, redness, and tenderness — generally resolving within days. Like all hyaluronic acid dermal fillers, treatment carries rare but serious vascular complication risks. Contraindicated in patients with known hypersensitivity to hyaluronic acid or lidocaine, active skin infection at the treatment site, pregnancy, or breastfeeding. Full contraindications, vascular complication protocols, aftercare, and emergency guidance are detailed on the dermal filler safety page.
Read Full Dermal Filler Safety Information →
Regenovue is a registered trademark of NeoGenesis Co. Ltd.. Fillersfairy.com is a channel distributor and does not provide medical advice. This page is for informational purposes only and does not replace the manufacturer’s official Instructions for Use, which remains the authoritative source for clinical administration. Regulatory status varies by jurisdiction — buyers are responsible for verifying legal status before ordering. Last reviewed May 2026 against NeoGenesis Co. Ltd. manufacturer documentation.
Michael Chen –
As a medical aesthetician, I appreciate how the ≤15min procedure time and ultra-fine needles (27-30G) make injections a breeze—especially with the SUB-Q PLUS config for volumizing cheeks. The product’s BDDE cross-linking innovation (with 98.6% conversion rate) ensures uniform particle size (350-500μm), so gel spreads evenly and lasts the advertised 9-12 months. Lidocaine at 3mg/ml minimizes discomfort, and I’ve seen that 92.7% satisfaction in elasticity firsthand—patients rave about it.
James Wilson –
As a dermatologist who’s used various fillers for years, Regenovue Plus stands out for its precision and low-risk profile. I stock up with the 10-19 unit discount ($36.58 each—saves cash for my clinic), and it never disappoints. Clinical trials show 9-12 month longevity, and I confirm that—most patients retain elasticity for over a year, matching the 92.7% satisfaction data.
Emma Davis –
As someone new to dermal fillers, I was nervous, but the 3mg/ml lidocaine really numbed things up, so I barely felt a thing during the injections. The product says it targets everything from fine lines (rhytids) to deep volume loss, and I saw immediate results after my first session. My skin looked plumper and smoother right away.Plus, storing it at 4°C pre-use made it feel fresh. At $38.50 a syringe, it’s worth every penny for how long it lasts (I’m still seeing effects 10 months in).