Korean HA Dermal Filler · Reanzen · 4 Variants
Replengen with Lidocaine — Korean Hyaluronic Acid Dermal Filler in Fine, Deep, Volume & Implant S
A Korean dermal filler series from Reanzen Co., Ltd. featuring 24 mg/mL cross-linked hyaluronic acid sourced from Shiseido (Japan), with 0.3% lidocaine for comfortable injection. Four variants cover fine lines, mid-depth folds, volume restoration, and deep tissue augmentation. Built on proprietary GI grinding and HAMC moisture correction technologies for smooth flow and extended duration.
Professional use only — for licensed aesthetic practitioners.
Last reviewed: May 2026 · Manufacturer: Reanzen Co., Ltd., South Korea
4 Variants
Fine · Deep · Volume · Implant S
Shiseido HA
Japan-Sourced
Side-By-Side
Replengen vs Restylane vs Juvederm Ultra
| Feature |
Replengen |
Restylane |
Juvederm Ultra |
| HA Concentration |
24 mg/mL |
20 mg/mL |
24 mg/mL |
| HA Source |
Shiseido (Japan) |
Bacterial fermentation |
Bacterial fermentation |
| Lidocaine |
0.3% (3 mg/mL) |
3 mg/mL (Lidocaine line) |
3 mg/mL |
| Gel Type |
Monophasic |
Biphasic (NASHA) |
Monophasic (Hylacross) |
| Cross-Linking Tech |
GI + HAMC |
NASHA |
Hylacross / Vycross |
| Variants Available |
4 (Fine / Deep / Volume / Implant S) |
8+ across Restylane family |
Ultra / Ultra Plus / XC |
| Duration (deep variants) |
12–18 months |
up to 18 months |
up to 12 months |
| Origin |
South Korea (Reanzen) |
Sweden (Galderma) |
USA (Allergan / AbbVie) |
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Comparison based on manufacturer published data. See our top dermal filler comparison guide for broader market context. Filler selection depends on indication, anatomy, and practitioner preference.
FAQs
Replengen with Lidocaine — Frequently Asked Questions
What is Replengen with Lidocaine dermal filler?
Replengen is a Korean cross-linked hyaluronic acid dermal filler series manufactured by Reanzen Co., Ltd. It contains 24 mg/mL cross-linked HA (sourced from Shiseido Japan) and 0.3% lidocaine for injection comfort. The series is available in four variants — Fine, Deep, Volume, and Implant S — each engineered for a different anatomical layer and clinical indication, from superficial fine lines to deep tissue augmentation.
What is the difference between Replengen Fine, Deep, Volume, and Implant S?
All four variants share 24 mg/mL HA and 0.3% lidocaine but differ in rheology and injection depth. Fine (30G, 60–100 Pa) targets superficial fine lines. Deep (27G + cannula, 160–200 Pa) is for mid-to-deep nasolabial folds. Volume (25G + cannula, 260–300 Pa, 1.7 mL syringe) handles cheeks, jawline, and chin. Implant S (25G + cannula, 260–360 Pa) is the highest viscosity for deep tissue augmentation.
Why is the Replengen Volume variant 1.7 mL instead of 1.1 mL?
Replengen Volume is engineered for larger anatomical zones — cheek, jawline, chin, and temple augmentation — where more product is typically needed per session. The 1.7 mL syringe (versus 1.1 mL in the other three variants) reduces the need for multiple syringes during a single volumising treatment, improving session efficiency for the practitioner.
How long do Replengen filler results last?
Replengen Fine typically lasts 6–12 months per the manufacturer’s data. Replengen Deep, Volume, and Implant S last 12–18 months thanks to higher cross-linking density and the HAMC technology that slows hyaluronidase degradation. Actual duration varies by injection site, patient metabolism, technique, and dose.
What are GI and HAMC technologies in Replengen?
GI (Grinding Irregular) is a proprietary HA particle grinding process that produces a homogeneous gel with consistent extrusion force. HAMC (Hyaluronic Acid Moisture Correction) is a high cross-linking method designed to slow enzymatic degradation, extending in-tissue duration. Together, the two technologies support smooth injection and the 12–18 month longevity claimed in the Replengen Deep, Volume, and Implant S variants.
Where is Replengen manufactured and who makes it?
Replengen is manufactured by Reanzen Co., Ltd., a Korean medical device manufacturer specialising in cross-linked hyaluronic acid dermal fillers. Production takes place in South Korea. The hyaluronic acid raw material is sourced from Shiseido Co., Ltd. (Japan), one of the leading high-purity HA suppliers in the industry.
Is Replengen FDA approved or CE certified?
Replengen is KFDA registered in South Korea. It is not currently FDA approved in the United States. Regulatory status varies by country and changes over time; buyers are responsible for verifying that import and clinical use are permitted in their jurisdiction before ordering.
Can different Replengen variants be combined in the same treatment session?
Yes — practitioners commonly layer multiple Replengen variants across different anatomical zones in one session. For example, Replengen Volume in the cheek midface, Replengen Deep in the nasolabial folds, and Replengen Fine for perioral lines. Because all four share the same HA source and cross-linking chemistry, biocompatibility within a layered approach is consistent.
How should Replengen be stored at the clinic?
Store between 2 °C and 25 °C, away from direct sunlight. Do not freeze. Shelf life is 24 months from the manufacturing date printed on the box. Once a syringe is opened, the contents must be used immediately — partial syringes cannot be retained for later use.
Does Replengen contain animal-derived ingredients?
No. Replengen uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products and is suitable for patients who avoid animal-derived medical products.
Important Safety Information
Read Before Clinical Use
Replengen is a prescription medical device for use only by licensed aesthetic practitioners. Common reactions include injection-site bruising, swelling, redness, and tenderness, generally resolving within days. Like all hyaluronic acid dermal fillers, treatment carries rare but serious risks. The Volume and Implant S variants involve deeper injection layers and warrant heightened anatomical awareness. Full contraindications, vascular complication protocols, aftercare, and emergency guidance are detailed on the dermal filler safety page.
Read Full Dermal Filler Safety Information →
Fillersfairy.com is a distributor and does not provide medical advice. This page is for informational purposes only and does not replace the manufacturer’s official Instructions for Use, which remains the authoritative source for clinical administration. Regulatory status varies by jurisdiction — buyers are responsible for verifying legal status before ordering.
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