Rejuran S vs Rejuran Healer | Collagen Stimulation, PDRN Concentration, Recovery Time

Healer is ideal for full-face anti-aging, with a recovery period of about 3 to 5 days. The S version, featuring a higher PDRN concentration and greater viscosity, is specifically designed for acne scar repair and requires roughly 5 to 7 days of downtime. Both options effectively stimulate collagen regeneration; please consult your doctor to determine the best treatment for your needs.

Collagen Stimulation

Full-Face Dermal Thickening

At age 25, the dermal layer of our cheeks typically measures between 1.8 and 2.0 millimeters thick. Inside, collagen forms a tight, sturdy network that supports the outer skin. Once we cross 35, this network thins by approximately 0.02 millimeters every year.

Injecting Rejuran Healer (the black box) aims to fill the spaces lost to aging. Practitioners precisely deliver a solution containing a 2% concentration of polynucleotides 1.5 millimeters below the skin’s surface, directly into the superficial dermis.

• Ultrasound imaging reveals a 20% to 30% increase in the skin’s internal density.
• The rate of transepidermal water loss on the face drops by 14.9%.
• Approximately 15 new microvessels sprout per square millimeter of skin.
• The outermost layer of the skin thickens by an average of 0.12 millimeters.

Unlike hyaluronic acid, which clumps into rigid masses, newly formed collagen follows the skin’s original structure, growing into a new network that spreads evenly in all directions. By the third week, tests show that elastin levels in the skin have increased by about 18% compared to pre-injection levels. As the microscopic gaps in the deeper skin layers are filled with this new material, fine lines on the surface are naturally pushed outward and smoothed away.

When 0.05 milliliters of the solution is injected per square centimeter of skin, the large molecules remain in place for several days. Sensing minor localized irritation, the body immediately dispatches blood to the area to initiate repairs. Within 48 hours, blood flow at the injection sites surges, delivering a massive supply of oxygen and nutrients. In essence, the body acts as the builder, while the solution simply provides the architectural blueprint.

By day 28, the collagen network beneath the skin reaches its peak density. Objective data from measurement instruments show that the skin’s firmness improves by approximately 12% compared to its initial state.

• The injection depth is strictly maintained within the 1.0 to 1.5-millimeter range.
• Each papule (bump) receives a dose of 0.02 to 0.05 milliliters.
• Covering the entire face evenly requires roughly 150 to 200 individual injections.
• A practitioner will use a total volume of 2 to 4 milliliters in a single session.

The dermis won’t continue to thicken indefinitely. Once it approaches the physiological limits of its youth, the cells naturally slow their activity. After completing several sessions as part of a treatment course, the overall thickness of the facial dermis can increase by about 15%. Over the next 6 to 12 months, this newly grown collagen network follows the body’s natural rhythm, slowly metabolizing at a rate of roughly 1% per year.

Seven days post-treatment, the capillary network beneath the skin has successfully formed, drastically accelerating the delivery of nutrients. Cheeks that once looked sallow and dull gradually reveal a healthy, pinkish-white glow. When a moisture meter is pressed against the face, the stratum corneum’s hydration reading jumps from its usual 30% to over 45%.

As the subcutaneous network thickens, it simultaneously helps manage oily pores. By the fourth week, quantitative tests of sebum production in the T-zone show a reduction of about 21%. The deflated, slack areas around the pores are plumped up by new collagen; when looking in the mirror, large pores exceeding 0.5 millimeters in diameter appear noticeably smaller.

• The thickening and firming effects are most pronounced in the fleshy areas of the cheeks.
• Since the skin on the forehead is less thick, injection points are spaced slightly further apart.
• The skin around the eyes is inherently extremely thin, measuring just 0.5 millimeters thick.
• The shriveled fine lines around the mouth require denser, more closely spaced injections to plump them effectively.

Throughout the entire growth process, polynucleotide molecules act as the foremen, issuing commands. Upon receiving these instructions, cells mobilize nearly 20 types of free amino acids within the body, spending hundreds of hours growing your very own collagen fibers. The injected solution contains no ready-made collagen; instead, it leverages a 98% DNA similarity to safely prompt the cells to do the work themselves.

When a specialized elasticity device is used to suction the cheek after a full course of three treatments, the skin’s resistance to pulling improves by about 16%. The reaction time for the skin to snap back after being suctioned is 22% faster than before. When these objective numbers translate to your face, it simply means your skin feels thicker and more substantial when you wash it.

Targeted Indentation Repair

Clustered rolling acne scars on the cheeks typically sink about 1.5 to 2.0 millimeters deep and cover an area of 2 to 4 square millimeters. The flesh at the base of the scar is tightly tethered to a mere 0.1-millimeter-thick layer of surface skin, creating a distinct dark shadow under lighting. When this tissue is examined under a microscope, it reveals that 70% of the collagen fibers within have long been severed and clumped together.

The practitioner uses Rejuran S (the red box), a solution with a staggering viscosity of 1,500,000 mPa·s—as thick as nearly dried glue. One milliliter of the product contains 20 milligrams of the active ingredient, with polynucleotide chains exceeding 3,000 base pairs in length. The active ingredients form an extremely dense cross-linked network, resulting in a gel that is virtually devoid of flow once injected.

Targeting a square acne scar 3 millimeters in diameter, the practitioner inserts an ultra-fine 30G needle, with an outer diameter of just 0.31 millimeters, straight into the base of the scar. By pushing 0.02 milliliters of the solution inward, a transparent fluid pocket approximately 0.5 millimeters thick immediately forms at the bottom. The shriveled, indented skin is forcefully and physically leveled out within seconds.

The highly viscous solution forcefully props open an isolated micro-space of about 0.03 cubic centimeters within the tissue. Degrading at a slow rate of just 15% to 20% per day, the gel firmly supports the base of the scar for 3 to 5 days. During this time, the repair materials gradually seep into the tight crevices within a 1.5-millimeter radius surrounding the site.

Fibroblasts at the base of the scar become densely surrounded by the solution’s components. Within 48 hours, their proliferation rate skyrockets to 140%, working day and night to generate fresh tissue. The surrounding blood supply aggressively transports nearly 20 types of amino acids to the damaged area, providing a continuous stream of building blocks for the synthesis process.

During the first 14 days, a significant amount of fresh tissue emerges within a 0.5-square-centimeter heavily affected area. Type III collagen, which serves as the foundational layer, accounts for 60% of this new tissue, thoroughly packing the base of the scar. By day 21, the sturdier, more durable Type I collagen takes over, comprising up to 80% of the tissue and securely reinforcing the entire base structure.

When dealing with large, undulating rolling scars, the practitioner switches to a 38-millimeter-long 23G blunt cannula, inserting it subcutaneously to break the fibrous bands pulling down the skin. The vertical downward tethering force on the scar’s base instantly drops by over 80%. The tightly restricted epidermis is thus freed, gaining roughly 1 millimeter of generous space to grow upward.

A full 1-milliliter syringe of the red box solution is divided into dozens of tiny portions, meticulously filling the newly created spaces from the subcision. A few drops of blood triggered by the cannula mix with the highly viscous solution, incubating a closed nutrient pool beneath the skin. The platelet count in the local interstitial fluid surges to 300,000/μL, locking all the flesh-growing nutrients deep at the bottom of the scar.

The concentration of growth factors tasked with generating new tissue at the base of the scar spikes by approximately 40% within 72 hours. These powerful biological signals attract three times the usual number of macrophages. Swarming the area, the macrophages bite by bite devour and clear away the old scar tissue, carving out 0.2 cubic millimeters of empty space for new flesh to form.

At the day 28 follow-up, a 3D skin scanner records a visible elevation at the base of the scar. A crater that was originally 1.2 millimeters deep now measures just 0.9 millimeters. This 0.3-millimeter growth equates to filling 25% of the depression with the patient’s own authentic tissue.

A single injection session can only elevate the base of the scar by 15% to 25%. To completely level a mature, years-old scar, a mere 0.02-milliliter spot dose is far from enough to fill the lost volume. However, rushing the process by forcefully injecting more than 0.1 milliliters per spot will push local tissue pressure past 30 mmHg, crushing all surrounding blood vessels.

The newly formed tissue takes 3 to 4 weeks to fully solidify. By day 10, the redness and swelling subside, and running a finger over the site of the old scar reveals a slightly firm, 2-millimeter nodule beneath the skin. The capillary density within the tissue increases by 18%, working around the clock to supply oxygen and nutrients to the new flesh.

Returning for monthly touch-ups to complete the standard three-session course results in a cumulative thickness of 0.5 to 0.8 millimeters of new tissue at the scar base. Standing under an overhead light and tilting the face 45 degrees in front of a mirror reveals that the shadowy area of the facial depressions has shrunk by 60% to 70%. When touching the outer layer of the face, the overall smoothness is vastly improved.

Once the glue-like gel is injected into the base of the scar, it migrates less than 0.1 millimeters per day. The 0.05-milliliter fluid rigidly holds its ground within a designated 2-millimeter radius. The solution absolutely refuses to spread into adjacent healthy tissue, maintaining a precise grip on the heavily damaged 0.1-square-centimeter area.

Synthesis Cycle & Recovery Time

Within the first 24 hours after receiving Rejuran Healer, the face is densely covered with over 150 translucent little bumps, each about 2 millimeters in diameter. This is the result of the practitioner forcefully pushing 2 milliliters of solution 1.5 millimeters under the skin, mechanically forcing open tiny fissures approximately 0.1 millimeters wide within the tight tissue.

“Before the solution is fully absorbed, running your hand over your cheek feels like touching a rough sheet of Braille paper.”

The scar-specific red box solution is extraordinarily thick, drastically slowing its absorption rate. The hard nodules injected into the base of the scars remain firm even past the 72-hour mark, feeling distinctly like foreign bodies when washing the face. The body temperature at the injection sites elevates slightly by 0.5 degrees; this mild localized inflammation summons the body’s entire fleet of immune cells, causing macrophage clusters to surge to 4 times their normal numbers.

• The small halo of redness around the injection points will fade by about 80% within 48 hours.
• The small bumps from the thinner black box solution typically flatten out in an average of 24 to 36 hours.
• Extremely dry skin, being highly adept at absorbing moisture, sucks up the solution roughly 4 hours faster than heavily oily skin.
• For the first three days post-injection, the outermost layer of the skin is extremely fragile, causing the rate of facial water loss to spike temporarily by 15%.

Once you endure the initial days of swelling and tenderness, looking in the mirror on the morning of day seven reveals cheeks that look dewy and radiant. But make no mistake—this isn’t new tissue growth. It’s entirely the work of the polynucleotide macromolecules and their aggressively dominant water-binding capabilities; just 1 gram of the product fiercely grabs onto up to 10 grams of surrounding water molecules, physically plumping the face with hydration.

The actual work of building tissue occurs quietly beneath the surface, completely invisible to the naked eye. Free-floating components of the solution attach themselves to the surface of fibroblasts, and the speed at which the cell nucleus receives instructions increases nearly threefold within a week. Once the collagen-producing machinery powers up, blood flow in the surrounding capillaries immediately jumps by 20%, bringing in massive gulps of oxygen and nearly 20 types of amino acid raw materials.

“The stunning results seen in the first few days are largely an illusion created by the solution drawing in water; solid, genuine dermal tissue takes time to stack up bit by bit.”

By day 14, subtle changes are occurring in the deep crevices hidden from the naked eye. Soft, pliable Type III collagen is produced first, acting like the fine river sand used to lay a foundation for a house, blanketing the damaged, hollowed-out areas with a thin layer. The micro-punctures on the surface have healed, and the skin’s tolerance to various chemical ingredients in daily skincare products recovers to over 95%.

Heading into the third week, after the immune system has swept away the old debris, the thick, sturdy Type I collagen begins to arrive in bulk. Its daily production climbs steadily, eventually making up 80% of all newly formed tissue volume. This new material weaves a robust network within the previously deflated, porous dermis, pushing the collapsed, wrinkled outer skin upward by approximately 0.05 millimeters.

When a specialized elasticity device tests the cheek’s bounce-back ability—pressing down heavily with a probe and then releasing—the skin’s rebound time is shortened by about 0.2 seconds compared to the original 0.8 seconds. When you slide your fingers along your jawline while washing your face at night, it no longer feels like soft, empty skin; the adhesion between the underlying flesh and the outer skin has improved by roughly 30%.

• The 28-day span perfectly aligns with the full turnover cycle of facial epidermal cells shedding and renewing.
• The most robust Type I collagen works the hardest during the fourth week, hitting a peak synthesis efficiency of 75%.
• Under a 3D scanner, readings show the depth of fine lines on the forehead becomes shallower by an average of 0.15 millimeters.
• The redness index measured by a colorimeter steadily drops by about 12%, signaling that the skin’s underlying foundation has grown thicker.

A single injection yields a “growth dividend period” that sustains the skin’s rapid proliferation until roughly day 45. The foreign solution itself is completely broken down and eliminated by the body within the first three weeks, leaving the residual growth momentum to carry the process forward. It takes hundreds of hours for the collagen fibers to slowly sort themselves out, transforming from a chaotic jumble of yarn into neatly aligned, thick ropes.

Returning for the second and third touch-up sessions in the following months strictly reinforces these growth commands over and over. With every successive layer of solution, the tissue density within the dermis increases by another 5% to 8% built upon the previous foundation. Pushing all the way to day 90, the newly formed tissue completely hardens and sets; at this exact point, the firmness felt in the cheeks reaches its absolute peak.

“Force-ripened fruit never tastes sweet; only a network meticulously woven over thousands of hours by your own cells will be truly strong and resilient.”

PDRN Concentration

Rejuran Healer

Pushing open the door to the treatment room, the digital display on the temperature-controlled cabinet reads 8 degrees Celsius. Rejuran Healer (the black box) is stored year-round in an environment between 2 and 25 degrees Celsius. Tearing open the rectangular paper box reveals two pre-filled glass syringes containing a clear liquid, with the markings stopping precisely at the 2ml line.

The assisting nurse will prepare extra Japanese JBP nano-needles. These needles are finer than a human hair, typically 33G or 34G, with a metal shaft length of exactly 4mm.

Applying the numbing cream takes up the majority of the pre-procedure time. A thick layer of cream containing 10.56% compound lidocaine is slathered over the face and sealed with clear plastic wrap. It takes 40 to 50 minutes for the medication to penetrate, gradually numbing the pain-sensing nerve endings in the epidermis.

After wiping off the numbing cream, the facial skin takes on a temporary pallor as the superficial capillaries constrict from the cold.

• Standard full-face dose per session: 2.0ml
• Needle penetration depth: 1.0mm to 1.5mm
• Distance between injection points: approx. 1.0cm
• Volume dispensed per point: 0.02ml to 0.05ml

The practitioner wields the beveled fine needle, piercing the epidermis at a 30- to 45-degree angle. The nucleotide liquid, at a concentration of 20mg/ml, is pushed into the superficial dermis. Immediately, raised circular papules measuring 3 to 5 millimeters in diameter appear across the skin.

The solution has a pH level between 6.5 and 7.5. Forcing this highly concentrated substance into the already tight space of the dermal layer compresses the surrounding tissue. Even with the numbing cream, patients still experience a distinct, intense aching sensation in their cheeks. When injecting near the edges of the nasolabial folds, it’s common for physiological tears to uncontrollably spill from the eyes.

Stepping off the treatment bed, the face is peppered with dozens of densely packed white bumps. The body’s interstitial fluid slowly seeps in, merging with the 2ml of foreign liquid. Over the next 24 to 48 hours, the gel-like active substances spread and flatten out along the intercellular spaces.

It takes roughly 72 hours for the tiny red puncture wounds left by the needle to scab over and fall off. The nurse applies a sterile medical mask, chilled to minus 4 degrees, over the face. A 15- to 20-minute cold compress helps subside the majority of the redness and swelling.

• 48 hours post-injection: The rate of epidermal water loss slows down.
• 14 days post-injection: The moisture content in the stratum corneum increases by about 15%.
• 28 days post-injection: Ultrasound scans detect a thickening of the dermal layer.
• Complete cycle: 3 consecutive sessions spaced 3 to 4 weeks apart.

Fibroblasts in the basal layer of the skin absorb the 2% nucleotide concentration. The damaged and fragmented reticular tissue regenerates fresh Type I collagen. Correspondingly, the rate at which sebaceous glands secrete oil slows down. Around day 7, individuals with dry, dehydrated skin often notice their faces no longer look oily before washing.

The first 72 hours belong to the self-repair phase for these micro-injuries. The epidermis loses a bit more water on the first day, requiring the application of a panthenol-based ointment 2 to 3 times daily. It is crucial to avoid toners containing salicylic acid; acidic liquids with a pH below 3.5 will irritate the unhealed injection sites.

Injecting 2ml of pure Rejuran Healer is undeniably painful. Experienced practitioners will often dispense 3ml of uncrosslinked hyaluronic acid into a sterile tray and mix the two liquids together. Hyaluronic acid can lock in 1,000 times its weight in moisture, perfectly replenishing the water consumed by the cells during repair.

Manual injections are far more precise than using a machine. A Derma Shine injector equipped with a 9-pin multi-needle can cover the entire face using suction in just 15 minutes. However, due to the machine’s strong suction and the thick consistency of the solution, 10% to 15% of the product is wasted, lining the inside of the tubes. In contrast, meticulously injecting point-by-point by hand takes nearly 40 minutes.

The skin under the eyelids is only about 0.5mm thick. When treating fine lines around the eyes, the 4mm metal needle tip can only be inserted up to a third of its length. The angle of insertion is kept extremely shallow, gliding into the skin almost flat at 15 degrees. The amount of liquid squeezed out with each poke is strictly kept under 0.01ml.

• Targeted dosage for both cheeks: 1.0ml to 1.2ml
• Forehead dosage: 0.4ml to 0.6ml
• Dosage around both eyes: 0.2ml to 0.3ml
• Dosage for fine lines around the mouth: 0.3ml

Rejuran S

The packaging box is noticeably smaller than the standard high-capacity model. Inside sits a single glass syringe holding a mere 1ml of volume. The syringe is filled with nucleotides at a concentration of 20mg/ml, but its physical state is exceptionally thick. If you hold the glass tube upside down in a room at 20 degrees Celsius, the transparent gel inside barely moves.

Before the injections, the nurse uses a marker to draw a dozen or so circles on the areas with the most severe acne scars. Beneath those deep, narrow craters lie stiff, rigid fibers that drag the epidermis tightly downward. The practitioner swaps out the needle for a slightly thicker 30G needle with a sharp metal bevel.

The metal tip punctures the base of the drawn circles, stopping at a depth of 1.5 to 2.0 millimeters beneath the skin. With a flick of the wrist, the practitioner vigorously maneuvers the needle back and forth; a faint “click” of snapping fibers can be heard subcutaneously. Once the tough cords tethering the skin are severed, the depressed epidermis springs up, creating a bit of space.

This newly created subcutaneous void must be quickly filled with the high-density solution. Pressing hard on the plunger with the thumb, the practitioner precisely dispenses 0.03 to 0.05ml of the extremely thick liquid into each scar.

The injected gel stays exactly where it is placed, refusing to spread into the surrounding tissue. The surfaces of dozens of old, deep scars transform into whitish, firm bumps. When touching the face while washing during the first 3 days, you can clearly feel small, somewhat hard supports under the skin, while the surrounding tissue aggressively absorbs water.

This clump of highly viscous gel provides a scaffolding for the cells to climb. The severed fibroblast tissue multiplies and grows upward along this structure. Clinic logbooks record the real-world progress of this 1ml solution filling different types of acne scars.

For rolling scars with smooth edges, the underlying fibrous adhesion accounts for less than 15% of the total facial area. Three consecutive sessions, spaced about 4 weeks apart, use up a total of 3ml of the high-density gel. At the 90-day follow-up, the newly grown subcutaneous granulation tissue raises the undulating surface by approximately 2 millimeters.

Ice pick scars have openings smaller than 2 millimeters but extend so deep they nearly touch the subcutaneous fat layer. Standard intense pulsed light devices can’t reach that depth, but the thick solution is channeled straight to the bottom of the pit via the needle tip. After three monthly sessions, the narrow, pore-like openings narrow by an average of 0.5 millimeters.

A single clinic visit usually focuses only on the dozen or so worst, deepest scars on the face. The 1ml volume isn’t enough to cover the whole face, and forcing a shallow, full-face application increases the likelihood of allergic redness by 20%. Practitioners often take the remaining 0.2ml and inject it just above the periosteum deep within the nasolabial folds for volume restoration.

In the 48 hours after the needle is withdrawn, the cheeks are a couple of shades redder than usual. The once-flat white bumps turn into dark, firm lumps tinged with the color of a bruise. A few drops of seeping blood mix into the gel, and it takes the body’s macrophages about 5 days to entirely phagocytize and clear the bruising.

It takes 3 to 4 weeks for the body to completely degrade and absorb the thick solution hidden beneath the skin. Washing the face each morning, patients can feel that the once-sunken crater bases have gained tissue volume. By day 14, the edges of the scars, where foundation used to constantly cake, can smoothly hold a 0.1-millimeter-thick layer of liquid foundation.

Patients with severely scarred faces typically return at the 6-month mark for facial photographs. On the 3D topographical map generated by the VISIA scanner, the area of subcutaneous dark shadows is reduced by more than half. For severe cases where over 40% of the face is pitted, practitioners will often stack a high-energy fractional CO2 laser treatment on the epidermis on the same day.

The intense light instantly burns away 10% of the dead stratum corneum and the superficial dermis. Pushing 1ml of the thick solution immediately after this resurfacing doubles the absorption rate of the ingredients into the heated skin. The time it takes for scabs to fall off drops from 7 days to around 5, drastically reducing the chances of leaving dark hyperpigmentation marks later.

Clinical Application

Holding a millimeter-scale vernier caliper, the practitioner leans in close to the cheek to measure a few small indentations. Seven ice pick scars deeper than 1.5 millimeters are counted on the left side of the face. Above the right cheekbone, a patch of skin roughly 4 square centimeters is red and peeling.

The practitioner flips open the medical chart on the desk and hastily jots down the numbers: 2ml for the full-face foundation, plus 1ml of the extra-thick formula specifically to fill those severe craters.

People walking into the clinic rarely have just one simple issue. Their foreheads are dry and peeling, while their chins are covered in hard, painful-to-touch scars. Relying on just one syringe of the thinner solution won’t address both extremes. On the peak Saturday afternoon schedule, six patients are specifically booked for this combined, dual-syringe protocol.

The assisting nurse approaches carrying a stainless steel tray holding two distinctly different glass syringes. One is filled with 2ml of a clear, fast-flowing liquid; the other contains 1ml of a solution as thick as semi-solidified glue.

• Full-face base: Switch to an ultra-fine, short needle with a 34G gauge and a length of just 4 millimeters.
• Targeted scar filling: Attach a sharp, long needle with a 30G gauge and a length of 13 millimeters.
• Numbing and waiting: Apply a thick layer of 10.56% lidocaine cream over the entire face and set the alarm for 45 minutes.

The thick needle with the beveled edge is targeted at six deep craters near the jawbone, performing subcision. The extremely viscous 1ml solution is divided into over a dozen tiny 0.05ml drops. Placed 1.5 millimeters deep beneath the skin, the thick gel pad forcefully pushes the collapsed skin up by nearly 1 millimeter.

As soon as the deep craters are packed with the thick gel, the practitioner immediately swaps out the thick needle for the millimeter-long fine needle to tackle the remaining 90% of the unscarred skin.

The thinner 2ml liquid is injected at an angle into the superficial layer, 0.8 to 1.0 millimeters beneath the skin. 0.6ml is evenly distributed across the forehead, while each cheek receives 0.5ml. The surfaces of the scars just subcised by the thick needle are coated once more with this thin nutrient solution. Pinched between the upper and lower layers, the overall thickness of the facial skin is forcefully expanded by nearly 15%.

The overlapping pain from the two injection techniques causes the heart rate monitor to instantly spike past 110 beats per minute. The nurse quickly presses two soft rubber stress balls into the patient’s hands. Pushing the thick gel deep into the tissue causes a dull, swelling ache, while the dense array of superficial injections leaves behind a burning, stinging sensation.

• Blood pressure shifts: Systolic pressure surges by an average of 10 to 15 mmHg.
• Facial temperature increase: The skin area injected rises about 1.2 degrees Celsius above normal.
• Pain rating scale: On a 10-point pain scale, most people consistently score it a 6 or 7.

Resting on the sofa post-procedure, both cheeks are densely covered with nearly 80 small, pale bumps. Beneath the deep scars treated with the thick solution, distinct hard lumps have formed; gently touching the area feels like a small mung bean is buried in the flesh. The nurse retrieves a chilling ice mask from the minus-4-degree refrigerator and applies it.

Lying with the ice mask for 20 minutes, the swollen facial capillaries constrict from the cold, and the redness values on both cheeks visibly drop by nearly 30%.

Walking out the clinic doors, the first priority is avoiding the glaring sun. The face is left with nearly 100 microscopic puncture marks. UVA rays from the sun can easily penetrate the flesh through these pinpricks and awaken the underlying melanin. Before heading out, a layer of SPF50, PA+++ sunscreen is applied to the cheeks, with the total volume for the whole face strictly equaling the size of 1.5 one-yuan coins.

Returning for a follow-up visit on day 14, the VISIA machine captures the first set of before-and-after data. The area of superficial skin redness from inflammation has decreased by 22%. The forehead, which used to feel tight and flaky after washing, can now comfortably withstand being in a dry, air-conditioned room with only 30% humidity.

The small patch of thick gel sitting beneath the deep craters hasn’t completely dissolved yet. Pressing firmly on the acne marks on the left cheek, one can still feel about 0.02ml of solid gel remaining under the skin. The fragmented cells surround the partially dissolved gel, desperately growing new tissue outward.

• 30 days post-injection: The number of superficial fine lines around the eyes and mouth drops by roughly 12%.
• 60 days post-injection: The previously uneven edges of the acne scars feel about 35% smoother.
• 90 days post-injection: The thickness of Type I collagen in the dermal layer reaches its absolute peak.

A single clinic visit consumes a total volume of 3ml. To protect the hard-won fresh granulation tissue, another 2ml injection of the standard thin solution must be administered in the 4th week. After enduring the half-year follow-up cycle, measurements show that the deep ice pick scars on several patients’ faces have successfully shallowed by roughly 0.5 millimeters.

Recovery Time

Rejuran Healer

While you recline on the treatment bed, a nurse applies a 2mm-thick layer of 5% compound topical anesthetic cream—containing 2.5% lidocaine and 2.5% prilocaine—to your face, then seals it under a disposable PE cling film for 40 minutes. As the sensory nerve endings beneath the epidermis are completely numbed, your face will feel as stiff as a board. Right before the procedure, the doctor will open a heat-sterilized foil packet in front of you, revealing a syringe filled with 2ml of a clear, sterile solution with a pH of 7.4.

The doctor uses an ultra-fine 34G needle, which has an outer diameter of only 0.18mm and an inner diameter of roughly 0.06mm—about a third thinner than a standard household sewing needle. The needle’s total length is 4mm. Inserting it at a 15 to 30-degree angle, the doctor delivers the solution directly into the reticular dermis, about 1 to 1.5mm below the skin’s surface.

To evenly distribute the 2ml of liquid across the entire face, the doctor must perform approximately 250 to 350 rapid, precise injections:

• The injection volume per point is strictly controlled at 0.01 to 0.015ml.
• The spacing between injection points on the cheeks and jawline is maintained at 1.0cm.
• In areas with thinner skin, such as around the eyes and mouth, the spacing is reduced to 0.5cm.
• The injection depth is carefully calibrated to avoid the main subcutaneous blood vessels located 3 to 5mm below the skin.

The inside of the syringe barrel is coated with approximately 0.05mg of medical-grade dimethicone to ensure a smooth glide when pressing the plunger. Administering over 250 injections across the whole face takes about 15 to 20 minutes. Because the subcutaneous fat on the forehead is extremely thin—only 0.5 to 0.8mm thick—the physical resistance of the needle tip tapping against the frontal bone’s periosteum will make the injection feel quite rigid to the doctor.

As the highly viscous, 20mg/ml solution enters the dense dermis, it forcefully expands the microscopic gaps between collagen fibers, which are normally only a few micrometers wide. Small, round bumps measuring 2 to 3mm in diameter will quickly rise on the skin’s surface, each with a volume of about 0.015 cubic centimeters. Minor capillary ruptures may cause about 0.1ml of slight bleeding. The nurse will apply pressure with sterile gauze for 30 seconds, forming tiny, dark red scabs at the injection sites.

Internal tissue pressure doubles after the solution is injected, increasing epidermal tightness by roughly 30%. You will experience a distinct, physical swelling and a dull ache that lasts for about 20 to 30 minutes. The nurse will then apply a sterile medical cooling mask (chilled to about 4℃) for 15 minutes. This drops the epidermal temperature by 3 to 5℃, constricting capillaries and reducing the likelihood of tissue fluid oozing by 40%.

During the first hour after leaving the clinic, the topical numbing cream wears off, and a widespread flush appears across the cheeks:

• Over 200 small, plump bumps protrude, sitting about 1 to 1.5mm above the skin’s surface.
• Pinpoint-sized drops of pale yellow tissue fluid may seep from roughly 15% of the injection sites.
• Facial capillary congestion raises the local skin temperature by 1 to 2℃.
• Facial expressions will trigger a slight pulling sensation in the skin as underlying muscles move.

When you lie flat to sleep at night, the change in posture slows facial blood return by about 20%. The large-molecule solution, with a molecular weight ranging from 50 to 1500 kDa, slowly absorbs water within the subcutaneous gaps. Looking in the mirror the next morning, you will notice that the swelling and height of the bumps have reduced by roughly 70%, thanks to a night of tissue fluid dilution and macrophage phagocytosis.

Your face will no longer feel as uneven as sandpaper; from a meter away, it will simply look slightly puffy, as if fully hydrated. When washing your face, running your fingers gently over your cheeks will reveal tiny, unabsorbed granules just beneath the 0.1mm-thick epidermis. Because the skin barrier has been pierced hundreds of times, the transepidermal water loss (TEWL) rate spikes from a normal 15g/m²/h to 35g/m²/h, leaving your face feeling unusually dry and tight.

The moisture content of the outer stratum corneum drops below 10%, necessitating the application of a Class II medical aesthetic mask containing sodium hyaluronate for 15 minutes every morning and night. By the 48-hour mark, patients with a fast metabolism will see 95% of the bumps flatten out. The small fraction of solution injected into the extremely thin skin under the eyes (only 0.2 to 0.5mm thick) takes an extra 12 to 24 hours to be cleared by surrounding lymphatic vessels.

Strictly following an hour-by-hour aftercare schedule can shorten the awkward redness phase by 24 to 36 hours:

• Do not let the wounds touch tap water or any unpurified water within 6 hours post-treatment.
• After 12 hours, apply a spray containing recombinant humanized type III collagen.
• For the first 48 hours, strictly avoid rubbing your face with cleansers containing harsh SLS foaming agents.
• After 72 hours, apply a pure physical zinc oxide sunscreen offering broad-spectrum protection from 290 to 400nm.
• Discontinue skincare products containing AHAs over 5% or retinol over 0.1% for 14 days.

As the solution degrades, its monomer molecules bind tightly to the A2A adenosine receptors on the surface of subcutaneous fibroblasts. The dermis then mass-produces bundles of type III collagen fibers, roughly 50nm in diameter, filling in all the gaps previously broken by 320 to 400nm UVA rays. By day 14, the smoothness of the stratum corneum significantly improves, and the cheek skin’s refractive index to natural light increases, resulting in a visibly dewy, radiant complexion.

The density of the subcutaneous tissue peaks on day 28. Under an ultrasound, the dermal thickness increases by an average of 8% to 12%, and static fine lines around the eyes shallow by 15% to 20%. A complete treatment protocol requires a follow-up session 28 days later. Three consecutive sessions—delivering a total of 6ml and 120mg of the solution—will build a collagen support network in the dermis that lasts for 8 to 12 months.

Rejuran S

The nurse hands the doctor a smaller syringe containing 1ml of solution, also at a 20mg/ml concentration. However, this liquid does not flow like water; its viscosity is more than three times that of standard hyaluronic acid. To the naked eye, it looks more like a tube of clear, thick jelly.

To target depressed acne scars that have been on the face for three to five years, the doctor swaps the ultra-fine needle used for the full face for a 30G needle with a 0.3mm outer diameter. This slightly larger gauge ensures the highly viscous solution does not clog the barrel during injection. The insertion angle is also increased to a steeper 45 degrees.

The bases of boxcar scars on the cheeks are anchored by tough fibrotic bands that pull the skin downward. The doctor inserts a 0.8mm medical blunt cannula horizontally along the superficial fat layer, 2 to 3mm beneath the skin, and performs a mechanical subcision, sweeping back and forth three times within the tissue.

You can clearly hear a “crunching” friction sound near your ear, much like taut nylon threads being snipped beneath the skin. As the localized fibrotic bands are mechanically severed, the base of the deep scar is released from its downward tethering. This is accompanied by about 0.2ml of subcutaneous bleeding visible on the skin’s surface.

Following the newly created subcutaneous pockets, the doctor precisely injects the highly viscous solution directly beneath the deepest point of the depression. A dose of 0.05 to 0.1ml is administered per scar, effectively planting a transparent, 0.05-cubic-centimeter jelly scaffold within the tissue.

The dense solution forcefully packs the subcised space, quickly raising a firm, 5 to 6mm bump on the surface. Because capillaries around the insertion site are damaged during subcision, leaked red blood cells will cause a purplish-red bruise to form in the area within minutes.

For the first 24 hours after leaving the clinic, the surface temperature of the treated side of your face will be roughly 2℃ higher than normal. When chewing food, the movement of the jawbone contracts facial muscles. The viscous solution lodged beneath the skin will press against surrounding pain receptors, triggering distinct, throbbing aches and sharp twinges.

Looking in the mirror the next day, the once-sunken acne scars will have transformed into tiny, raised red hills. If you gently press these bumps with clean fingers, they feel somewhat like cooked soybeans.

The high-viscosity solution degrades extremely slowly in the subcutaneous tissue; it takes a full 120 hours for your body’s macrophages to dissolve its outer layers. By day 5, the hard nodules on your face will have slowly shrunk by half, but the firm structural support beneath them remains very evident.

As the red blood cells in the subcutaneous bruising break down, the hemosiderin inside slowly settles. The purplish-red bruising surrounding the scars fades into a dark yellow by day 7. This discoloration spreads outward by about 1.5cm, looking exactly like an old bruise from bumping into the corner of a table.

After day 10, applying a thin layer of a non-chemical, titanium dioxide-based tinted sunscreen can conceal 80% of the fading yellow-green bruises. Deep within the tissue, the solution is slowly cleaved into monomeric deoxyribonucleotides. New surrounding capillaries begin growing into the deficit area at a rate of 0.1mm per day.

From day 14 onward, a sterile ointment containing epidermal growth factors (EGF) should be applied to the scars twice daily, morning and night. This nearly doubles the growth rate of stratum corneum cells, sealing the final 0.2mm micro-wounds left by the subcision needle.

Post-Treatment Care Requirements

For the first 6 hours after leaving the clinic, your face is covered with 250 to 350 microscopic injection sites, each 0.06mm in diameter. Platelets in your blood are actively gathering at these punctures, taking about 2 to 3 hours to form tiny scabs. During this crucial window, absolutely no unpurified water should touch your face. Even sweat dripping from your forehead must be immediately dabbed away with sterile gauze.

Tap water harbors over 100 bacteria per milliliter. If bacteria infiltrate the unhealed 0.18mm-wide puncture wounds, the risk of capillary inflammation jumps by nearly 50%. If your cheeks feel hot and tight, you may only use a sterile facial towel dampened with 0.9% medical saline to gently blot away the approximately 0.5ml of pale yellow exudate.

“The microscopic punctures on your face remain open and slightly weeping for 6 hours, while adjacent epidermal cells migrate toward the center at a speed of 0.1 to 0.15mm per hour, working desperately to seal these micro-wounds.”

By the evening of the treatment, facial redness and swelling reach their peak, with subcutaneous capillaries dilating to 1.5 times their normal size. You must apply a Class II sterile medical mask that has been refrigerated to 4℃, strictly limiting application time to 15 to 20 minutes. This cold compress forces the enlarged, deep capillaries to rapidly constrict within 5 minutes.

Post-icing, subcutaneous fluid seepage drops immediately by 40% to 50%. The mask contains 0.2% hyaluronic acid or recombinant collagen, which penetrates the compromised epidermis to drag the TEWL rate back down to a normal 15g/m²/h. Do not rinse your face after removing the mask; simply let the residual essence air dry for 3 to 5 minutes.

After you’ve passed the 48-hour mark, the sub-0.5mm scabs at the injection sites will harden and flake off, meaning the skin’s protective barrier is about 60% healed. When washing your face, never use a cleanser packed with strong SLS foaming agents. Harsh cleansing ingredients exceeding a 5% concentration will strip away large areas of the fragile, newly formed sebum layer.

It’s best to use a mildly acidic amino acid cleanser with a pH between 5.5 and 6.0. Squeeze about 1.5g into your palm, lather it up, and gently press it in circular motions across your face. Reduce your scrubbing force by more than half compared to your usual routine to avoid tearing the freshly bridged new granulation tissue. Rinse with lukewarm water (35℃ to 37℃) for just about 30 seconds.

• Discontinue serums containing AHAs over 5% or salicylic acid over 2%.
• Avoid anti-aging creams containing retinol concentrations higher than 0.1%.
• Do not apply botanical skincare products packed with essential oils exceeding a 1% concentration.
• Hold off on using home radiofrequency (RF) beauty devices emitting at 1MHz to 3MHz for thermal lifting.
• Elevate your pillow by about 15 degrees when sleeping; gravity will help speed up nighttime facial blood return by roughly 20%.

Between days 3 and 5, about 70% of the 2ml solution has been absorbed by the tissue, leaving just a few dark red injection marks on the cheeks. Sun protection becomes critical at this stage, as the basal melanocytes irritated by the 34G needle are highly reactive. If exposed to UVA rays with wavelengths between 320 and 400nm, they will pump out melanin at three times their normal rate.

Under no circumstances should you use chemical sunscreens containing OMC (Octinoxate). Chemical sunscreens must be absorbed into the skin and require the face to heat up by 1 to 2℃ to dissipate UV rays, which will aggravate and redden the newly healed injection sites. Switch to a pure physical sunscreen where titanium dioxide or zinc oxide is the primary ingredient, and apply a thick, coin-sized amount across your face.

“The particles in physical sunscreens are generally 200 to 400nm or larger in diameter, making them too big to clog the micrometer-scale crevices of healing skin. They act like a mirror, physically bouncing away over 90% of UV rays.”

During the initial 7-day recovery period, any plans for intense, sweaty gym sessions must be paused. Heavy workouts on the treadmill will push your heart rate past 120 beats per minute and spike your blood pressure by about 15mmHg. As facial blood circulation accelerates, the previously flattened bump areas will flush aggressively red again, lingering for 2 to 3 hours.

Absolutely avoid saunas exceeding 40℃ or hot yoga studios cranked to 38℃. Extreme heat will forcibly dilate the delicate, 0.02mm-thick capillaries in your face. If the free-floating collagen network newly tethered in your tissue is constantly subjected to hot environments, the redness reduction time for new blood vessels will be drastically prolonged by 5 to 7 days.

Avoid consuming any beverages with an alcohol content above 5% with your meals. Acetaldehyde, which is produced when alcohol breaks down in the liver, drastically dilates blood vessels, flooding the compromised subcutaneous tissue with inflammatory agents. A face that would have naturally de-puffed in 3 days will flare up again when triggered by alcohol, subjecting you to an additional 48 to 72 hours of discomfort.