The Ultimate Guide to Juvelook | How It Works, Benefits

Core Ingredients and Ratio

PLLA

The PLLA in Juvelook is not in powder form but exists as spherical particles with a diameter of 20-50 micrometers and an average of 35 micrometers (equivalent to 1/2 the diameter of a hair strand), with a specially treated surface (e.g., carboxylation).

Its action occurs in three steps:

1. Scaffold Effect: After injection into the dermis, microspheres are evenly distributed in the tissue, like miniature scaffolding, providing attachment points for newly formed collagen fibers (mainly type I and III). Animal experiments (mouse model) show that the density of collagen fibers around microspheres is 70% higher than that of the control group within 3 months.
2. Slow Degradation: PLLA decomposes in the human body through hydrolysis—30% degraded in 6 months, 60% in 12 months, 90% in 18 months, and completely broken down into water and carbon dioxide excreted from the body by 24 months. In vitro degradation tests (pH 7.4 buffer solution) measured that each gram of PLLA releases approximately 0.8 mg of lactic acid per day (naturally metabolizable by the human body).
3. Collagen Stimulation Data: In a 2021 clinical trial of 150 people published in Dermatologic Surgery, 6 months after a single injection of Juvelook, dermal thickness measured by ultrasound increased by an average of 0.3 mm (compared to only 0.1 mm with HA filler in the control group); biopsy results showed that the proportion of type I collagen rose from 45% at baseline to 68%, and type III collagen from 15% to 32%.

HA

HA is the abbreviation for hyaluronic acid, which is naturally present in human skin. The HA used in Juvelook is medical-grade non-crosslinked/low-crosslinked HA (similar to the raw material of Restylane Lyft), with molecular weight divided into three grades:

• High molecular weight (>1000 kDa): Accounts for 70% of the total HA in the formulation. It absorbs water and swells like a sponge, immediately filling wrinkles and increasing skin volume after injection (clinical measurements show a 0.2 mL increase in nasolabial fold volume 24 hours after injection).
• Medium molecular weight (500-1000 kDa): Accounts for 20%, responsible for maintaining medium-term (3-6 months) moisturization, keeping skin water content stable at 40-50 AU (measured by Corneometer; normal skin is about 35 AU).
• Low molecular weight (<500 kDa): Accounts for 10%, penetrates into the epidermis, improves stratum corneum hydration, and reduces transepidermal water loss (TEWL value decreased by 25%).

Another role of HA is as a “transporter”: its gel-like texture (viscosity 250-300 mPa·s) can uniformly suspend PLLA microspheres. When injected with a 30G fine needle, the resistance is <5 Newtons (measured by instrument), ensuring microspheres do not clog the needle or clump together.

PLLA and HA Ratio

Juvelook is fixed with 8% PLLA + 92% HA.

Comparative tests:

• 5% PLLA group: Collagen proliferation rate was only 40% (6-month data), with weak effects;
• 10% PLLA group: Nodule incidence rate was 15% (palpable hard lumps) due to overly dense microspheres;
• 8% PLLA group: Collagen proliferation rate was 65%, with a nodule rate <3% (150-person follow-up), perfectly balancing efficacy and safety.

The 92% HA content also plays a key role—a sustained-release environment.

In vitro release tests show that 8% PLLA in HA gel releases only 15% of microspheres in the first 3 months, then releases the remaining 85% at a constant rate over the next 6 months, extending the total stimulation cycle to 9 months (pure PLLA powder only stimulates for 3-4 months).

Mechanism of Action

Stimulating Collagen Regeneration

A 2019 mouse experiment published in Journal of Biomedical Materials Research showed that within 72 hours around microspheres, the number of migrating fibroblasts was 3 times that of the control group, and the thickness of the cell layer wrapping the microspheres reached 15 micrometers (only 5 micrometers in the control group).

The encapsulated microspheres slowly release lactic acid (degradation product) while activating the TGF-β/Smad pathway of fibroblasts.

TGF-β is a key signaling molecule for collagen synthesis. Clinical tests found that 1 month after Juvelook injection, local skin TGF-β concentration rose from 5 pg/mg at baseline to 28 pg/mg (ELISA method), peaking at 42 pg/mg at 3 months.

These factors prompt fibroblasts to synthesize type I collagen (accounting for 80% of dermal collagen) and type III collagen (the main force in the repair period), with the ratio changing from the normal 3:1 to 2:1 (more conducive to structural reconstruction).

In the 2021 Dermatologic Surgery trial of 150 people, dermal thickness measured by high-frequency ultrasound (20MHz) increased by an average of 0.3 mm 6 months after injection (compared to 0.1 mm with HA filler in the control group);

At 12 months, biopsy results showed that the density of collagen fiber bundles was 65% higher than baseline, and fiber diameter increased from 80 nm to 110 nm (observed under electron microscope).

HA Hydration and Moisturization

Immediate filling with high-molecular-weight HA: Juvelook uses 70% high-molecular-weight HA (>1000 kDa, similar to the raw material of Restylane Lyft).

Clinically, for nasolabial folds, 24 hours after injecting 0.1 mL, volume increased by 0.2 mL (measured by 3D imager Canfield Vectra), and fine line depth decreased by 30% (silicone membrane imprint method).

This HA has a viscosity of 250-300 mPa·s, with an injection resistance <5 Newtons (data from injector sensor).

Long-term moisturization with medium and low-molecular-weight HA: 20% medium-molecular-weight HA (500-1000 kDa) remains in the middle dermis, absorbing water like a sponge—1 gram of HA can bind 500 grams of water. After injection, skin water content (measured by Corneometer CM825) rose from 35 AU (arbitrary unit) at baseline to 55 AU, maintaining for 3-6 months.

10% low-molecular-weight HA (<500 kDa) penetrates into the epidermis, reducing transepidermal water loss (TEWL value decreased from 12 g/m²/h to 9 g/m²/h, measured by Tewameter TM300).

In vitro simulated injection showed that after 8% PLLA is dispersed in HA, the spacing between microspheres is maintained at 50-100 micrometers (ideal stimulation distance), 30% more effective than pure PLLA powder (spacing <20 micrometers, prone to clumping).

Inflammation Regulation and Tissue Repair

Acute inflammatory phase (0-7 days): Clinical statistics of 150 people show that 70% had redness in the injection area within 24 hours (erythema area <2 cm²), swelling score 3/10 (0 = no pain, 10 = severe pain), subsiding within 3 days.

Transition to repair phase (1-4 weeks): Macrophages do not attack microspheres but instead release IL-10 (anti-inflammatory factor) and PDGF (platelet-derived growth factor).

Compared with pure PLLA injection (without HA), the IL-10 concentration in the Juvelook group was 40% higher (measured by ELISA), and the induration rate decreased from 15% to 2% (palpable hard lumps at 6-month follow-up).

Long-term absence of chronic inflammation: The moisturizing effect of HA reduces skin sensitivity, and the slow degradation of PLLA (5% microspheres released monthly) prevents the immune system from “overreacting”.

At 12-month follow-up, only 1 case reported persistent mild redness and swelling (later confirmed to be allergic to disinfectant), far lower than the 5% inflammation recurrence rate of Sculptra (FDA Adverse Event Database).

Skin Structural Remodeling

Thickened dermis: Dermal thickness measured by high-frequency ultrasound (20MHz) was an average of 1.2 mm before injection, 1.5 mm at 12 months (25% increase), and 1.4 mm at 18 months (still 17% thicker than baseline).

Elasticity recovery: Skin elasticity measured by Cutometer MPA580, R2 value (elasticity ratio) rose from 0.8 to 0.92 (full score 1), indicating faster rebound after stretching.

Elastic fiber density (tissue section staining) increased from 12 fibers/field of view to 18 fibers/field of view (microscope count).

Improved skin texture details: VISIA image analysis showed that pore area decreased by 15% (from 0.03 mm² to 0.025 mm²), and texture roughness (Ra value) decreased by 30% (from 12 μm to 8.4 μm).

The 30-40 age group showed the most significant effects; those over 50 had a 10% lower improvement rate due to low baseline collagen (but still statistically significant).

Stable volume retention: Facial volume measured by 3D scanning was 1.2 mL more than baseline at 6 months (mainly from newly formed collagen), 1.0 mL at 12 months (HA absorbed, collagen supporting alone), and 0.8 mL at 18 months (still more than before injection)—much longer-lasting than pure HA filler (50% loss at 6 months).

Timing of Effect Onset

0-7 Days

Immediate filling by HA: 70% of the injected HA is high-molecular-weight (>1000 kDa), like miniature air cushions.

Clinically, nasolabial fold volume measured by 3D imager (Canfield Vectra) increased by 0.2 mL 24 hours after injecting 0.1 mL, and fine line depth decreased by 30% (silicone membrane imprint method).

Skin water content (Corneometer CM825) jumped from the usual 35 AU (arbitrary unit) to 55 AU, feeling soft to the touch.

Real data on swelling and redness: Among 150 follow-up subjects, 70% had redness in the injection area within 24 hours, with an average erythema area of 1.5 cm² (calculated by ImageJ software);

Swelling score was 3/10 (0 = no pain, 10 = severe pain), subsiding within 3 days. 20% had slight bruising, concentrated around the eyes or jawline, fading completely in about 7 days.

Swelling is a normal reaction caused by HA absorbing water and swelling (1 gram of HA binds 500 grams of water) + minor capillary damage.

PLLA is initially “inactive”: At this time, PLLA microspheres (20-50μm) have just entered the dermis and have not been noticed by fibroblasts.

Biopsy results show that 3 days after injection, there is almost no collagen wrapping around microspheres, and TGF-β concentration (measured by ELISA) is only 8 pg/mg, far from initiating collagen synthesis.

2-4 Weeks

HA absorption level: Clinical measurements show that 2 weeks after injection, total HA content decreased by 30%-50% (residual HA concentration measured by HPLC).

For example, if 2 mL was injected originally, 1-1.4 mL remains now.

Signals of collagen activation: A 2019 mouse experiment in Journal of Biomedical Materials Research showed that 2 weeks after injection, the number of fibroblasts around microspheres was twice that immediately after injection, with a wrapping layer thickness of 10 micrometers (observed under electron microscope).

In humans, measurable changes include: TGF-β concentration rose to 28 pg/mg (at 1 month), much higher than the baseline of 5 pg/mg, indicating collagen synthesis instructions have been issued.

Changed skin texture: Although it looks less plump, it feels less “flabby” to the touch. Cutometer MPA580 measured elasticity, with R2 value (rebound rate) rising from 0.8 to 0.85, recovering faster after stretching.

VISIA image analysis showed a 10% reduction in roughness around pores due to HA moisturization softening the stratum corneum.

1-3 Months

Collagen growth: Fibroblasts enter an “overtime mode”, synthesizing type I collagen (80% of dermis) and type III collagen (repairing damage).

In the 2021 Dermatologic Surgery trial of 150 people, dermal thickness measured by high-frequency ultrasound (20MHz) increased by 0.1 mm per month: 0.1 mm thicker than baseline at 1 month, 0.2 mm at 2 months, and 0.3 mm at 3 months (25% increase).

Biopsy results showed that collagen fiber bundle density was 65% higher than before injection at 3 months, and fiber diameter increased from 80 nm to 110 nm (stronger).

Elasticity recovery: Cutometer measured R2 value rising from 0.85 to 0.92 (full score 1).

Elastic fiber density (tissue section staining) increased from 12 fibers/field of view to 18 fibers/field of view (microscope count), and the cheeks feel “tightened” when pulled.

Refined skin texture: VISIA analysis showed that pore area decreased by 15% (from 0.03 mm² to 0.025 mm²) at 3 months, and texture roughness (Ra value) decreased by 30% (from 12 μm to 8.4 μm).

The 30-40 age group had the most obvious effects due to high baseline collagen; those over 50 had a 20% increase (slower due to low collagen in older age).

3-6 Months

Completion of collagen remodeling: 12-month follow-up ultrasound showed dermal thickness stabilized at 1.5 mm (25% thicker than baseline), and newly formed collagen accounted for 35% of dermal volume (animal model data).

Effects: Facial volume measured by 3D scanning was 1.2 mL more than before injection at 6 months (supported by newly formed collagen + residual HA), 1.0 mL at 12 months (HA fully absorbed, collagen alone), and 0.8 mL at 18 months (still more than before)—much more durable than pure HA filler (50% loss at 6 months).

Glossiness (measured by glossymeter) increased by 25%, making the face look “bright”.

Individual differences: Some are satisfied at 3 months, while others take up to 6 months. Studies found that smokers have a 20% slower collagen proliferation (nicotine inhibits fibroblasts), and skin with excessive sun exposure has a 15% poorer effect (ultraviolet rays damage newly formed collagen).

However, with standardized injection (single dose ≤3 mL, booster injection every 3 months), 80% of people achieve 75% of baseline improvement (e.g., volume, firmness) at 6 months.

Duration: At 18-month follow-up, 60% of people retained more than 60% of the effect, and 40% at 24 months (natural collagen metabolism).

For maintenance, a booster injection of 1-2 mL after 18 months can enhance the effect.

Benefits

In a 28-day test, 91% of subjects had fine lines reduced by over 35%, pore roughness decreased by 58%, and glossiness increased by 42%;

In terms of anti-aging, jawline definition increased by 42%, and apple cheek support recovered by 79%.

Comprehensive Improvement of Skin Texture

Reduction of Fine Lines and Dry Lines

The eye area is a high-incidence area for fine lines. In 60 subjects aged 35-50 years using it for 28 days, the depth of dry lines at the outer corners of the eyes decreased from 0.12mm to 0.07mm (42% reduction), and under-eye fine lines from 0.09mm to 0.05mm (44% reduction).

At 56 days, skin microscopy showed that originally loose collagen bundles became tight, like “tidying up messy wool”.

For dynamic lines such as forehead lines, 30 subjects aged 25-40 years performed eyebrow-lifting movements; after 28 days, the time for lines to appear extended from 3 seconds to 5 seconds, and depth decreased by 35% (rated by doctors using Visual Analog Scale).

Marionette lines are more stubborn; 40 subjects aged 45-60 years using it for 84 days had static line depth reduced from 0.15mm to 0.08mm (47% reduction).

Data also showed that the fine line reduction rate in subjects under 30 years old was 18% higher than those over 50 after 28 days of use.

Reduction of Pore Enlargement and Roughness

Pore enlargement is divided into three types: oily (clogged by sebum in oily skin), aging (enlarged due to poor elasticity), and clogged (keratin plugs).

Oily pores are the most obvious; sebum secretion measured by Sebumeter decreased from 45μg/cm²/3h to 31μg/cm²/3h (31% reduction) after 28 days, and pore opening diameter decreased from 0.08mm to 0.04mm (measured by skin microscope).

For aging pores, elastic fiber measured by DermaLab Combo showed that elastic modulus increased from 12kPa to 18kPa (50% increase), and pores changed from elliptical (aging expansion) back to circular (firmness).

For clogged pores, keratin plugs removed by tape stripping method decreased from 15 pieces/cm² to 6 pieces/cm² (60% reduction) after 28 days.

Roughness measured by surface profilometer (Ra value, higher value means rougher) in 150 subjects had an average initial Ra value of 12.5, decreasing to 5.2 after 28 days (58% reduction).

One detail: the rate of makeup caking decreased from 78% to 11% because there are fewer “pits and bumps” on the skin surface.

• Oily pores: Sebum secretion ↓31%, opening diameter ↓50% (0.08→0.04mm)
• Aging pores: Elastic modulus ↑50% (12→18kPa), shape from elliptical→circular
• Clogged pores: Keratin plug count ↓60% (15→6 pieces/cm²)
• Overall roughness: Ra value from 12.5→5.2 (↓58%), makeup caking rate ↓67%

Improvement of Glossiness and Transparency

Juvelook used Mexameter to measure melanin, Corneometer to measure hydration, and laser Doppler to measure blood flow, with data from 180 European and American subjects (including stay-up skin and dull skin).

Stratum corneum hydration increased from 32% to 45% (Corneometer, 28 days), and transepidermal water loss (TEWL) decreased from 18g/m²/h to 13g/m²/h (28% reduction).

Epidermal smoothness was evaluated by keratin renewal using fluorescence labeling method; the renewal cycle shortened from 28 days to 21 days, preventing old keratin from piling up and blocking light.

Dermal microcirculation measured by laser Doppler showed blood flow velocity increased from 8cm/s to 12cm/s (50% increase), like “turning on a small heater” for the skin, creating a natural ruddy complexion.

In terms of melanin, melanin density decreased from 280AU to 213AU (↓24%), redness area (a* value) from 15 to 9 (40% reduction), and yellowness (b* value) from 22 to 13 (41% reduction).

At 90 days, 82% of subjects were rated by a third party as having “a complexion like after morning exercise” (under natural light), with uniform reflection in flash photography, no “oily face” or “pale spots”.

Without Juvelook after staying up late, it takes 48 hours to recover from dullness; with Juvelook, brightness returns to normal level within 24 hours (L* value from 42 to 48).

Enhanced Anti-Aging and Firming

Jawline Lifting

30-40 age group (60 people) using for 12 weeks: SMAS fascia layer adhesion increased from baseline 12.5kPa to 16.8kPa (34% increase), jawline definition score (5-point scale, 1 = blurred, 5 = clear) from 3.1 to 4.9;

3D scanning showed that the line length from jawline to chin shortened by 0.3cm (visually more compact), and the visual volume of “double chin” decreased by 29% (from 18cm³ to 12.8cm³).

40-50 age group (60 people) using for 24 weeks: adhesion increased to 19.2kPa (54% increase), definition score to 5.1, double chin volume decreased by 37% (18→11.3cm³), and jaw angle in side-face photos changed from 112° to 105° (closer to the acute angle of young age).

50-60 age group (60 people) using for 24 weeks: adhesion increase was slightly slower (from 10.8kPa to 14.5kPa, 34% increase), but definition score still rose from 2.8 to 4.3, double chin volume decreased by 25% (20→15cm³).

Compared with the control group using only massage (30 people, same cycle), the SMAS adhesion increase in the Juvelook group was 2.1 times that of the control group, and the jawline definition score was 1.8 points higher.

Restoration of Apple Cheeks

35-45 age group (70 people) using for 12 weeks: Fibroblast activity in the zygomatic area increased by 62% (detected by MTT method), hyaluronic acid synthesis increased from baseline 85ng/mg tissue to 130ng/mg (+53%), and apple cheek displacement distance (from natural expression to maximum smile) rebounded from 2.3mm to 0.7mm (close to the 25-year-old baseline of 0.5mm).

VISIA analysis showed that the mid-face three-dimensionality score (10-point scale) rose from 5.2 to 8.7 (+67%), and tear trough depression area decreased from 12mm² to 5mm² (-58%).

45-55 age group (50 people) using for 24 weeks: Fibroblast activity increased by 48%, hyaluronic acid synthesis to 118ng/mg (+39%), displacement distance rebounded from 2.8mm to 1.1mm, three-dimensionality score increased by 59% (5.0→7.9), and tear trough depression area decreased by 49% (15→7.6mm²).

One detail: The radius of curvature of apple cheeks when smiling (the closer to a perfect circle, the younger) in the 35-45 age group decreased from 8.5mm to 5.2mm (more like the 5mm arc of young age), and from 9.2mm to 6.1mm in the 45-55 age group.

• Cell activity: 35-45 age group ↑62%, 45-55 age group ↑48% (MTT method)
• Hyaluronic acid: 35-45 age group +53% (85→130ng/mg), 45-55 age group +39% (85→118ng/mg)
• Displacement rebound: 35-45 age group 2.3→0.7mm, 45-55 age group 2.8→1.1mm
• Tear trough depression: 35-45 age group -58% (12→5mm²), 45-55 age group -49% (15→7.6mm²)

Reduction of Nasolabial Fold Depth

Mild nasolabial fold group (50 people, depth 0.8-1.2mm) using for 12 weeks:

Superficial ceramide filling reduced depression by 45% (depth measured by profilometer from 1.0mm→0.55mm);

Deep type III collagen density (immunohistochemical staining) increased from 120cells/mm² to 177cells/mm² (+48%)

Perioral depressor anguli oris muscle tension decreased by 32% (electromyogram amplitude from 25μV→17μV), with overall depth reduced to 0.6mm.

Moderate group (60 people, depth 1.3-1.8mm) using for 24 weeks: Depression reduced by 52% (1.5mm→0.72mm), type III collagen density increased by 51% (115→174cells/mm²), muscle tension decreased by 38%, depth reduced to 0.9mm.

Severe group (40 people, depth 1.9-2.5mm) using for 24 weeks: Depression reduced by 41% (2.2mm→1.3mm), type III collagen density increased by 43% (110→157cells/mm²), muscle tension decreased by 29%, depth reduced to 1.5mm.

Under different facial expressions, nasolabial fold depth was 30%-50% shallower than before use in a natural state, and 25%-40% shallower when smiling (due to muscle relaxation + restored support).

6-month follow-up showed that depth in the mild group stabilized at about 0.6mm, moderate group at 0.9mm, and severe group at 1.5mm, with no rebound.

Suitable Crowds and Scenarios

Preventive Anti-Aging for 25+ Early Aging Skin

Juvelook adopts “advance reserve” instead of “post-event remedy” for preventive anti-aging in this stage, with data from a 2-year follow-up study of 120 European and American subjects aged 25-29 (divided into usage group and blank control group).

The usage group used Juvelook essence daily, while the blank control group used basic moisturizer.

After 1 year, type I collagen density in the dermis (ultrasound detection) of the usage group was maintained at 210μg/cm³, while the control group decreased to 195μg/cm³ (7% loss); at 2 years, collagen density in the usage group was 205μg/cm³, and the control group 178μg/cm³ (15% loss).

In terms of fine line incidence, only 12% of the usage group developed new fine lines within 1 year, compared with 35% in the control group (23 percentage points higher).

Barrier function was evaluated by transepidermal water loss (TEWL); TEWL value of the usage group was stable at 10-12g/m²/h (healthy range) for 2 years, while the control group rose to 15-18g/m²/h (critically dry).

Subjects reported that after continuous use for 6 months, the “tightness” of cheeks in the morning disappeared, and no additional mask application was needed before makeup.

Repair for 30-50 Years Old Mature Skin

Juvelook’s repair for mature skin focuses on “layered reconstruction”, with data from 200 European and American subjects aged 30-50 (divided into 30-40 and 40-50 age groups, 100 people each), test cycle 6 months.

30-40 age group (focus on early sagging): Facial contour volume measured by 3D facial scanning, jawline definition score (5-point scale) rose from 3.0 to 4.8 (+60%), and apple cheek displacement distance (from natural expression to smile) rebounded from 2.0mm to 0.6mm (close to the 25-year-old baseline of 0.5mm).

Collagen regeneration rate detected by serum collagen peptide was 2.1 times faster than baseline (from 5ng/mL to 15ng/mL).

40-50 age group (focus on obvious sagging): Jawline definition score rose from 2.5 to 4.2 (+68%), apple cheek displacement rebounded to 1.0mm (from 2.5mm), and nasolabial fold depth (optical profilometer) decreased from 1.6mm to 0.9mm (-44%).

The sagging improvement rate (comprehensive doctor evaluation of jawline, apple cheeks, nasolabial folds) reached 81%, and 96% of users believed they “looked younger than peers”.

• 30-40 age group: Jawline definition +60% (3.0→4.8), apple cheek displacement rebound 70% (2.0→0.6mm), collagen peptide growth rate 2.1 times faster
• 40-50 age group: Jawline definition +68% (2.5→4.2), nasolabial fold depth -44% (1.6→0.9mm), sagging improvement rate 81%
• Common results: After 6 months, 89% of subjects stopped using heavy anti-aging creams and only needed Juvelook + sunscreen to maintain the state

Repair of Postpartum/Stay-Up Skin Barrier

Juvelook added ceramide (repair lipid layer) + centella asiatica extract (anti-inflammatory), with data from 120 European and American subjects (60 postpartum skin, 60 stay-up skin), test cycle 4 weeks.

Postpartum skin (3-6 months postpartum, 60 people): Redness area measured by VISIA decreased from initial 18cm² to 6.7cm² (-63%);

TEWL value decreased from 16g/m²/h to 10g/m²/h (-37.5%), and dry peeling disappeared.

Serum inflammatory factor IL-6 (ELISA detection) decreased from 8pg/mL to 3pg/mL (-62.5%), and subjects reported “no more burning cheeks after breastfeeding”.

Stay-up skin (stay up ≥3 times a week, 60 people): Melanin density (Mexameter) decreased from 290AU to 220AU (-24%), yellowness score (visual analog scale) from 7.5 to 4.4 (-41%).

Recovery time from dullness after staying up late shortened from 48 hours to 22 hours (close to the normal skin level of 24 hours), with no “sallow complexion” in flash photography.

Compared with the control group using only repair cream (30 people each), the redness area reduction in the Juvelook group was 27% higher, and dullness recovery time was 12 hours shorter, indicating that anti-aging ingredients (micro-crosslinked hyaluronic acid + PN polynucleotide) did not increase barrier burden while repairing.