Rejuran I 1ml

Why This Skinbooster Is Different

Mechanism of Action

Specifications

Product Name	Rejuran I 1ml
Category	Polynucleotide (Periocular)
Active Ingredients	20 mg/mL polynucleotide (PN 2%) from wild-salmon DNA, extracted via DOT™ (DNA Optimizing Technology), in purified water with pH-regulating buffer
Mechanism Class	DOT™ Polynucleotide Fibroblast Activator (periocular)
Manufacturer	PharmaResearch Bio Co., Ltd.
Origin	Republic of Korea
Pack	1 × 1 mL pre-filled syringe (White Box)
Lidocaine	Not included
Injection Technique	Micro-droplet placement at the orbital septum, lateral canthus, and infraorbital area
Injection Depth	Superficial dermis (1–1.5 mm) in periocular skin
Recommended Needle	32G or 34G ultrafine for periocular skin
Treatment Protocol	3 sessions, 3–4 weeks apart. Maintenance every 4 months.
Effect Duration	3–6 months after the initial 3-session course
Storage	2–25 °C, protect from light, do not freeze
Shelf Life	36 months unopened
Regulatory	CE-marked Class III medical device. KFDA-approved. Manufactured by PharmaResearch under KGMP and ISO 13485. PN extracted via patented DOT™ (DNA Optimizing Technology) from wild Korean salmon from Namdaecheon River.
SKU	FF-SB-REJURAN-I-1ML

Clinical Indications

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Frequently Asked Questions

What is Rejuran I 1ml?

Rejuran I is the periocular-specific product in the Rejuran polynucleotide family — packaged in the White Box. Each 1 mL syringe contains 20 mg PN (polynucleotide) extracted from wild Korean salmon via PharmaResearch's patented DOT™ Technology. It is designed for the delicate eye area: crow's feet, lower eyelid laxity, and dark circles.

How is Rejuran I different from Rejuran Healer (Black Box)?

Same active ingredient — 2% PN. Difference is positioning: Rejuran I is the 1 mL eye-area-specific SKU; Rejuran Healer (Black Box) is the classic 2 × 2 mL full-face SKU. Both products use the same DOT™ PN; the eye SKU is sized appropriately for bilateral periocular treatment.

How is Rejuran I compared to Vitaran i PN?

Both are 2% PN periocular boosters from Korean manufacturers. Rejuran I uses wild-salmon-derived PN extracted via PharmaResearch's DOT™ Technology. Vitaran i uses salmon-trout-derived PN via the HP Cell platform (LG Chem). Clinical performance is comparable; Rejuran has the larger brand recognition and broader regulatory clearance, Vitaran has the lower price point.

What is DOT™ (DNA Optimizing Technology)?

DOT™ is PharmaResearch's patented process for extracting and purifying polynucleotides from wild salmon DNA sourced from the Namdaecheon River in Korea. The process produces PN chains in the 500–5000 base pair range — optimal for fibroblast A2A receptor engagement — while removing protein contaminants that could trigger inflammation.

What needle gauge is used for Rejuran I?

32G or 34G ultrafine needles are standard for periocular skin. The thinner gauge minimises bruising risk in the highly vascularised orbital region. Micro-droplet placement at superficial dermal depth (1–1.5 mm) is the standard technique.

How many sessions are needed?

3 sessions spaced 3–4 weeks apart for the initial course. Visible improvement in periocular fine lines and skin tone typically appears 2–4 weeks after each session and accumulates. Maintenance is 1 session every 4 months.

Is Rejuran I effective for dark circles?

Yes — the PN-driven fibroblast activation improves periocular skin density and elasticity, addressing both the vascular component (skin quality, microcirculation) and the structural component (thin skin allowing underlying vessels to show through). Pigmentary dark circles benefit less and may need adjunctive treatment.

Is Rejuran I FDA-approved?

Rejuran is KFDA-approved in Korea (where it is the #1 polynucleotide brand) and CE-marked in the EU. As of 2026, the original Rejuran formulations are not FDA-approved in the US — PharmaResearch announced a US partnership with LaserAway in 2025 to introduce Rejuran's bioregenerator products to the US market via the Healing Essence and Tone-Up Booster format.

Where is Rejuran I manufactured?

Manufactured by PharmaResearch Bio Co., Ltd. in the Republic of Korea, under KGMP and ISO 13485. The PN active is extracted from wild Korean salmon from the Namdaecheon River.

How much does Rejuran I 1ml cost?

Rejuran I 1ml is priced at USD $88.00 per syringe on Fillersfairy, with wholesale pricing for licensed practitioners.

Source verification:→ FDA 510(k) Database (verification)

Related Skin Boosters

Regulatory Notice. CE-marked Class III medical device. KFDA-approved. Manufactured by PharmaResearch under KGMP and ISO 13485. PN extracted via patented DOT™ (DNA Optimizing Technology) from wild Korean salmon from Namdaecheon River. This product is manufactured outside the United States; FDA approval status is product-specific. For licensed healthcare professionals only. Practitioners are responsible for verifying regulatory status of this product in their jurisdiction before clinical use. Not for retail sale. Pricing subject to change.