Country of origin · United States / Germany
Radiesse® is an FDA-approved calcium hydroxylapatite (CaHA) biostimulator. The ready-to-use 1.5 ml syringe gives immediate volume from its gel carrier while the CaHA microspheres stimulate new collagen and elastin — an instant contour plus longer-term skin support.
Radiesse® is FDA-approved in the United States. It was first approved in 2006 for moderate to severe facial wrinkles and folds such as nasolabial folds, and is also FDA-approved for hand rejuvenation. It is a regenerative calcium hydroxylapatite (CaHA) biostimulator with more than two decades of clinical use.
Why choose Radiesse
How Radiesse stimulates collagen
On injection the gel carrier provides immediate volume, while the suspended CaHA microspheres prompt fibroblasts to build new collagen and elastin. The carrier is absorbed and the CaHA gradually metabolised, leaving the new collagen behind — an instant contour plus longer-term skin support.
Radiesse specifications
Radiesse treatment areas
The areas below are commonly treated with this category of product by practitioners. Suitability, technique, and dosing for any given area are determined by the treating practitioner based on individual patient anatomy and clinical judgment.
Contraindications
Radiesse — frequently asked questions
Radiesse® is a calcium hydroxylapatite (CaHA) collagen biostimulator. It is supplied ready-to-use in a 1.5 ml pre-filled syringe and provides both immediate volume and longer-term collagen stimulation.
Yes. Radiesse is FDA-approved in the United States. It was first approved in 2006 for moderate to severe facial wrinkles and folds such as nasolabial folds, and is also FDA-approved for hand rejuvenation.
Radiesse is FDA-approved in the United States and has been in clinical use for more than two decades.
Radiesse consists of calcium hydroxylapatite (CaHA) microspheres — roughly 30% by composition — suspended in an aqueous gel carrier of carboxymethylcellulose, glycerin, and sterile water. CaHA is identical in composition to the mineral component of bone.
Yes. Unlike powder-form PLLA stimulators, Radiesse provides immediate volume from its gel carrier on injection, while the CaHA microspheres additionally stimulate new collagen and elastin over the following weeks and months.
Results from Radiesse typically last in the range of 12 to 18 months depending on the area treated and individual factors. Duration varies by patient.
No. Radiesse is supplied as a ready-to-use pre-filled syringe and does not require reconstitution. If any dilution or mixing is used, the specific ratio and preparation are determined by the treating physician according to their technique and treatment goal. It is for single-patient use.
A hyaluronic acid filler adds volume by occupying space and is reversible with hyaluronidase. Radiesse is a biostimulator: in addition to immediate volume from its carrier gel, the CaHA microspheres stimulate new collagen and elastin, and it is not reversible with hyaluronidase.
Radiesse, Ultra CA+, and Volassom are all calcium hydroxylapatite biostimulators that work by the same mechanism. Radiesse is the FDA-approved original; Ultra CA+ and Volassom are Korean CaHA products. Microsphere size, carrier composition, and regulatory status differ between brands.

Dr. Emily Carter –
As a dermatologist, I’ve used Radiesse for years, and this 1.5ml filler is a game-changer for mid-face volume loss. The CaHA microspheres give immediate lift while stimulating collagen—I’ve seen results last 16+ months in my patients.
Sarah Johnson –
Okay, I was nervous trying fillers, but Radiesse blew me away,got it for my nasolabial folds. The swelling lasted 2 days, but by week 2, my skin looked plumper naturally. Not a ‘frozen’ look at all.