Quick Answer
Regenovue Aqua Shine Plus 3ml×3 by NeoGenesis is a Korean HA mesotherapy skinbooster — 15 mg/mL partially cross-linked hyaluronic acid with 0.3% lidocaine for comfortable application. Three pre-filled 3 mL syringes per box deliver a complete face + neck + décolletage course. Partial cross-linking gives it dual properties: immediate hydration like a meso product, plus 3–6 month duration like a light filler. Standard protocol is 3 sessions, 4 weeks apart.
Why This Product Is Different
Regenovue Aqua Shine Plus occupies a hybrid niche between pure mesotherapy and dermal filler. Unlike non-cross-linked mesotherapy products which last 4–8 weeks, Aqua Shine Plus’s partial cross-linking extends duration to 3–6 months. Unlike heavily cross-linked structural fillers, its low concentration (15 mg/mL) and partial cross-linking keep it suitable for superficial dermal placement without ridging or visible deposits. 0.3% lidocaine reduces injection discomfort — important for the multi-point mesotherapy delivery pattern.
Mechanism of Action
Partially Cross-Linked HA Biorevitalisation. Hyaluronic acid is a naturally occurring glycosaminoglycan in dermal extracellular matrix. Injected HA performs dual functions: (1) immediate physical hydration via water-binding (1 g HA binds up to 1000× its weight in water), and (2) biological signalling — exogenous HA stimulates resident fibroblasts to produce native HA, collagen, and elastin via CD44 receptor pathways. The partial cross-linking modulates degradation rate, extending in-situ residence time to 3–6 months versus 4–8 weeks for non-cross-linked HA.
Compare Within Category
Within Fillersfairy’s HA Skinbooster category, Regenovue Aqua Shine Plus competes with Revitrane HA20 (20 mg/mL monophasic), Hyaron (25 mg/mL non-crosslinked Dongkook), and Cytocare 516 (16 mg/mL French formulation). Aqua Shine Plus’s lidocaine inclusion is its distinct advantage for patient comfort during multi-point delivery.
Frequently Asked Questions
What is Regenovue Aqua Shine Plus?
Regenovue Aqua Shine Plus is a Korean HA mesotherapy skinbooster manufactured by NeoGenesis Co., Ltd. It contains 15 mg/mL partially cross-linked hyaluronic acid with 0.3% lidocaine, supplied in three 3 mL pre-filled syringes per box (9 mL total). The partial cross-linking gives it longer duration (3–6 months) than standard mesotherapy while keeping the product fluid enough for superficial dermal placement via mesotherapy or microinjection.
How is Aqua Shine Plus different from a standard dermal filler?
Standard dermal fillers (e.g. Restylane, Juvederm Voluma) use high HA concentrations (20–25 mg/mL) and strong cross-linking for structural volumising effect in deep dermis or subcutaneous placement. Aqua Shine Plus uses lower concentration (15 mg/mL) and partial cross-linking specifically to remain fluid enough for superficial dermal mesotherapy distribution — focused on hydration and texture rather than volume restoration.
Does the 0.3% lidocaine reduce injection pain?
Yes — significantly. Lidocaine is a local anaesthetic that takes effect within seconds of injection. For multi-point mesotherapy patterns (often 20–40 injection points per session for full face), the 0.3% lidocaine inclusion dramatically improves patient tolerance versus lidocaine-free alternatives. Topical anaesthesia 30 minutes pre-procedure is still recommended for sensitive patients.
How many sessions are needed?
Standard course is 3 sessions, 4 weeks apart — exactly what one 3-syringe box covers. Visible hydration and glow typically appears within 7–14 days of the first session. Texture and elasticity improvements accumulate through the course and persist 3–6 months after the third session. Maintenance is 1 session every 4–6 months.
Where can Aqua Shine Plus be injected?
Face, neck, décolletage, and back of hands. The product disperses well in superficial dermis without visible deposits. Avoid use in areas planned for filler placement within 4 weeks (potential interaction with cross-linked filler matrix). Not for lip vermillion border or fine periorbital areas where higher-precision products are preferred.
What is the injection technique?
Two main techniques. (1) Mesotherapy pattern: multiple 0.05–0.1 mL micro-deposits using 30G or included 27G½ needle at 1.5–2.5 mm depth, spaced 1.0–1.5 cm apart across treatment zone. (2) Microneedling pre-load: prime skin with microneedling, then apply Aqua Shine Plus to open channels for absorption. The mesotherapy pattern is the manufacturer’s recommended primary technique.
Are there any contraindications?
Standard HA filler contraindications. Avoid in pregnancy and lactation, active skin infection at injection site, known hypersensitivity to HA or lidocaine, autoimmune disease in active flare, anticoagulant therapy without medical clearance. Allergy testing not routinely required for non-animal HA but may be considered for highly atopic patients. Vascular precautions: have hyaluronidase available.
Does Aqua Shine Plus contain BDDE?
Yes — but at clinically negligible residual levels. BDDE (1,4-butanediol diglycidyl ether) is the cross-linking agent used in nearly all medical HA fillers. NeoGenesis specifies endotoxin below 0.1 EU/mL and ultra-low BDDE residuals (well below regulatory thresholds). After cross-linking, free BDDE is removed via extensive washing; any trace residual is degraded biologically without clinical relevance.
Where is Regenovue Aqua Shine Plus manufactured?
Manufactured by NeoGenesis Co., Ltd. in the Republic of Korea. The Regenovue product family is one of NeoGenesis’s flagship lines.
How much does Regenovue Aqua Shine Plus 3ml×3 cost?
Regenovue Aqua Shine Plus 3ml×3 is priced at USD $78.00 per box on Fillersfairy, with wholesale pricing for licensed practitioners. Each box covers one full 3-session course.
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