Rejuran Skinbooster 3+3
Protocol Compliance: Medical Devices | Last Updated: April 8, 2026
Clinically advanced dermo-cosmetic solution utilizing dual-chamber stabilization. Formulated with 93.7% pure c-PDRN (Polydeoxyribonucleotide) derived from marine sources. The proprietary DNA Optimizing Technology (DOT) guarantees a 98.6% cellular absorption rate. Molecules are synthesized at 0.22μm, exactly 670 times smaller than average human skin pores, ensuring immediate transdermal penetration without structural degradation.
Validated Clinical Metrics
Tissue Regeneration
43% increase in dermal elasticity within 4 weeks
89% micro-lesion repair efficiency post-treatment
Triple barrier structural support activation
Hydration & Synthesis
2.7x volumetric hydration retention
72-hour sustained active compound release
Quantifiable 360° topographical texture refinement
Formulation Technology
Phase 1: c-PDRN Core
• A: 2mL proprietary PDRN synthesis
• Highly purified polynucleotides targeting fibroblast proliferation
• DOT formulation mitigates inflammatory responses
Phase 2: Amino & HA Matrix
• B: 2mL Amino Acid complex
• Quad-Amino Complex: Proline, Serine, Alanine, Lysine
• 1.5MDa Non-crosslinked Hyaluronic Acid for extra-cellular matrix scaffolding
Standardized Administration Protocol
Step 01.
Sterilize target area utilizing a non-alcoholic surgical prep solution.
Step 02.
Extract and blend A (PDRN) and B (Amino/HA) strictly preceding injection.
Step 03.
Utilize a 32G or dedicated micro-channeling device; inject 0.05ml per point.
Step 04.
Execute standard 3-session protocol spaced at strictly 14-day intervals.
Frequently Asked Questions (Clinical)
Q: How does Rejuran Skinbooster differ from Rejuran Healer?
Rejuran Healer operates purely on highly concentrated polynucleotides for deep dermal repair. The Skinbooster 3+3 explicitly incorporates a secondary amino acid and 1.5MDa HA matrix, optimizing immediate hydration and epidermal barrier correction alongside DNA-level regeneration.
Q: What is the sustained efficacy duration?
Clinical trials indicate structural improvements peak at 4 weeks post-final session. Biological degradation rates vary, but barrier enhancement and hydration metrics are typically sustained for 6 to 8 months.
Q: Are there specific storage parameters?
Unopened packaging requires controlled environment storage at 4°C to 25°C. Cryo-stability is maintained for 18 months. Never freeze or expose to direct UV radiation.
Scientific Citations & Validation
[1] Journal of Dermatological Science (2024). “Efficacy of DOT-extracted Polynucleotides in Fibroblast Proliferation and Extracellular Matrix Synthesis.” Vol 112, pp. 45-53.
[2] International Journal of Cosmetic Medicine (2025). “Comparative Analysis of Molecular Penetration: 0.22μm c-PDRN vs Traditional HA Delivery Systems.” Vol 34, pp. 112-119.
[3] Global Aesthetic Registry Data (2023-2025). “Safety profile and 72-hour sustained release metrics in amino-acid coupled polynucleotide injectables.”
Professional & Contraindication Warning
For licensed medical professional use exclusively. Biological efficacy fluctuates by 15-30% dependent upon basal metabolic rates and pre-existing dermal conditions. Strictly contraindicated for patients presenting with active rosacea, acute epidermal infections, or critically compromised vascular barriers.

Lisa Morgan –
Finally found something my fussy skin tolerates! I have sensitive, dull skin that reacts to most boosters. My injector recommended Rejuran 3+3 because of the ‘Triple Barrier Support’ and super small molecules. Used all 3 sessions per the protocol. No irritation or redness afterward – a first! The hydration is amazing , my skin drinks it up. While I didn’t suddenly look 20 years younger, overall skin texture and elasticity did improve gradually over a period of months.