How Rejubella stimulates collagen
The PDO microspheres act as a temporary dermal scaffold; as the body resorbs them, fibroblasts are prompted to produce new collagen, improving dermal thickness and firmness. The PDO is fully metabolised while the induced collagen remains.
Rejubella specifications
Category
PDO Collagen Biostimulator
Country of origin
Republic of Korea
Material
PDO microspheres 10–60µm
Form
Lyophilized PDO microspheres for reconstitution
Composition
Polydioxanone (PDO) microspheres 150 mg; sodium carboxymethylcellulose (CMC) 150 mg — 300 mg total per vial
Pack
1 vial × 300 mg lyophilized PDO microsphere powder
Storage
Store at room temperature, protected from light. Do not freeze.
Shelf life
Per manufacturer labelling (unopened)
After reconstitution
Reconstitute per the practitioner’s standard protocol before injection.
Supplied to
Licensed healthcare professionals only
SKU
FF-PDO-REJUBELLA-300
Rejubella treatment areas
The areas below are commonly treated with this category of product by practitioners. Suitability, technique, and dosing for any given area are determined by the treating practitioner based on individual patient anatomy and clinical judgment.
Facial skin firmness and dermal thickness
Nasolabial folds and fine lines
Cheek and midface support
Skin texture and pore appearance
Overall collagen-stimulated rejuvenation
Neck and jawline skin quality
Contraindications
Pregnancy and lactation
Active infection, inflammation, or skin lesions at or near the intended treatment area
Known hypersensitivity to any component of the product
History of keloid formation or hypertrophic scarring
Bleeding disorders or anticoagulant therapy without appropriate clearance
Active autoimmune or connective tissue disease (relative — at practitioner discretion)
Rejubella — frequently asked questions
What is Rejubella 300mg PDO Filler?
Rejubella is a Korean polydioxanone (PDO) microsphere collagen biostimulator. Each vial contains 300 mg of spherical particles (10–60 µm) — 150 mg PDO plus 150 mg carboxymethylcellulose — supplied as a powder for reconstitution.
Where is Rejubella made?
Rejubella is developed and made in South Korea using patented microsphere technology.
What is PDO and is it safe?
Polydioxanone (PDO) is a synthetic, fully absorbable polymer that has been used for decades in surgical sutures. In microsphere form it acts as a temporary scaffold that stimulates collagen and is then gradually resorbed and metabolised by the body.
How does Rejubella work?
Rejubella’s PDO microspheres act as a scaffold in the dermis. As the body gradually resorbs them, surrounding fibroblasts are stimulated to produce new collagen, improving dermal thickness and skin firmness over time — a biostimulatory rather than purely space-filling effect.
Is Rejubella FDA-approved?
Rejubella is a Korean product and is not a US FDA-approved product. Practitioners should verify the product’s regulatory status in their jurisdiction before use.
How is Rejubella different from PLLA or CaHA stimulators?
Rejubella uses polydioxanone (PDO) microspheres, whereas products such as Olidia/Sculptra use PLLA and Radiesse/Ultra CA+ use CaHA. All are collagen biostimulators, but the base polymer, particle profile, and resorption characteristics differ.
How long do results last?
PDO microsphere biostimulators provide results that develop gradually as collagen forms and are reported to last around 12 months or more, with duration varying by individual.
How should Rejubella be stored?
Store unopened vials at room temperature, protected from light. Do not freeze. Follow the manufacturer labelling for shelf life.
Does Rejubella provide immediate volume?
As a biostimulator, Rejubella’s primary effect is gradual collagen formation. Any initial volume from the reconstituted suspension settles as the collagen-stimulating process develops over weeks to months.
Kaelen Thorne –
I was worried about nodules, which happens sometimes with PLLA if you don’t massage it right or if the product clumps. But Olidia seems much more forgiving. The volume came back gradually over 8 weeks. No lumps at all, just a very natural plump. Highly recommend it if you have hollow temples like I did.
Emily Carter –
The tracking system was spot-on; got updates from Seoul to my doorstep in 5 days. My patients love the subtle lift it gives within a week, especially for cheek augmentation. No clumping during injection, which matters when you’re doing 10+ treatments daily. Legit product with Korean certification seals intact.