Quick Answer
Rejuran HB Hydro Booster is the Red Box of the Rejuran family — combining DOT™ polynucleotide with non-crosslinked hyaluronic acid and premixed lidocaine in a single 1 mL syringe. The HA component delivers immediate hydration while the PN drives fibroblast regeneration; the lidocaine reduces procedural discomfort. Launched as the patient-comfort upgrade to the original Rejuran Healer.
Why This Skinbooster Is Different
Rejuran HB is the only Rejuran product with both HA and premixed lidocaine. The HA adds the immediate hydration that pure PN products like Healer or I lack — clinically meaningful for patients seeking visible same-day improvement. The lidocaine addresses the chief patient complaint about Rejuran (mesotherapy discomfort across many injection points). Positioned as the next-generation upgrade to Rejuran Healer for full-face biorevitalization.
Mechanism of Action
PN + HA Hybrid with Premixed Lidocaine (Hydro Booster). Non-crosslinked hyaluronic acid is co-delivered with DOT™ polynucleotide and lidocaine. The HA component provides immediate hydration and acts as a delivery medium that improves PN distribution across the tissue field. The PN drives the underlying fibroblast-receptor-mediated regenerative cascade. Lidocaine reduces procedural discomfort across the multi-puncture mesotherapy technique without affecting the biological mechanism.
Frequently Asked Questions
What is Rejuran HB Hydro Booster?
Rejuran HB is the hydrating + comfort-optimised product in the Rejuran range — packaged in the Red Box. It combines DOT™ polynucleotide with non-crosslinked hyaluronic acid and premixed lidocaine in a single 1 mL syringe. HB stands for 'Hydro Booster' — emphasising the added hydration over the original PN-only Healer formulation.
How is Rejuran HB different from Rejuran Healer?
Rejuran Healer (Black Box) is pure 2% PN — focused on fibroblast regeneration over weeks. Rejuran HB (Red Box) adds non-crosslinked HA (for immediate hydration) plus lidocaine (for procedural comfort). The HB formulation is positioned as the next-generation evolution — same PN active but with two practical enhancements addressing patient feedback on the original.
Why add HA to a PN product?
Pure PN products take 2 to 4 weeks for visible effect because fibroblast activation and collagen synthesis are biological processes that take time. Adding non-crosslinked HA delivers immediate hydration and plumpness on day one — patients see same-day improvement, then the PN-driven regeneration matures over the following weeks. This bridges the 'placebo gap' that pure PN products have for patient satisfaction.
How does lidocaine affect the treatment?
Standard injection of pure PN products (Healer, I, S) requires multiple punctures across the face, which patients describe as uncomfortable. Premixed lidocaine in Rejuran HB numbs the tissue as the product is delivered, reducing intra-procedural pain. This allows clinicians to use slightly larger doses per puncture and reduces the patient's perception of discomfort.
Does the HA in Rejuran HB add structural volume?
No — the HA is non-crosslinked (similar to Restylane Vital), meaning it provides hydration and acts as a delivery medium but does not build structural volume the way cross-linked HA fillers (Juvederm, Restylane LYFT) do. The mechanism is hydration + biorevitalization, not volume restoration.
How many sessions are recommended for Rejuran HB?
3 sessions spaced 3 to 4 weeks apart, the same protocol as standard Rejuran Healer. Maintenance is 1 session every 4 to 6 months. The added HA component means patients may notice improvement faster, but the underlying regenerative effect still requires the full course.
Can Rejuran HB be used in the periocular area?
Off-label yes, but Rejuran I (White Box) is the dedicated periocular SKU. Use Rejuran HB for full-face biorevitalization and reserve Rejuran I for eye-area-specific treatment. Combining them in one session for separate fields is a common protocol.
How is Rejuran HB compared to Vitaran PN?
Both are 2% PN full-face boosters from Korean manufacturers. Rejuran HB adds HA and lidocaine for patient comfort and immediate hydration. Vitaran PN is pure PN at 20 mg/mL without HA or lidocaine. Rejuran HB is positioned for patient experience; Vitaran PN is positioned as clean single-active. Pricing favours Vitaran PN at lower cost; brand recognition favours Rejuran HB.
Is Rejuran HB Plus the same as Rejuran HB?
Rejuran HB Plus is a more recent enhancement launched in 2024–2025, with additional PN content compared to the standard HB. The product on Fillersfairy under the SKU 'Rejuran HB Hydro Booster' is the standard HB. For HB Plus specifically, contact Fillersfairy customer service to confirm SKU availability.
How much does Rejuran HB Hydro Booster cost?
Rejuran HB Hydro Booster is priced at USD $88.00 per 1 mL syringe on Fillersfairy, with wholesale pricing for licensed practitioners.
Regulatory Notice. CE-marked Class III medical device. KFDA-approved. Manufactured by PharmaResearch under KGMP and ISO 13485. Combines DOT™ PN with non-crosslinked HA and lidocaine in a single syringe. This product is manufactured outside the United States; FDA approval status is product-specific. For licensed healthcare professionals only. Practitioners are responsible for verifying regulatory status of this product in their jurisdiction before clinical use. Not for retail sale. Pricing subject to change.
Learn more: Rejuran for Acne Scars · Rejuran Before and After Results
Evan Zhang –
My skin always flakes and gets super dry whenever the season changes, and no cream seemed to work. A friend suggested I try this HB version since it combines HA and salmon DNA. It’s been over two weeks since the treatment, and the biggest change is that my face isn’t dry anymore—it feels soft and bouncy, and my makeup doesn’t cake at all. The 1cc size is a bit small, but concentrating it on my cheeks gave amazing results. Definitely repurchasing.
Emma Wilson –
I am very picky about toxins. Nabota is FDA approved, which gives me peace of mind. The 200ui is super cost-effective if you treat multiple areas like crow’s feet, glabella, and neck bands all at once. It lasts about 3-4 months for me, exactly the same as the more expensive American brands. Highly recommend.
Lisa Rodriguez –
Cheap numbing creams used to leave my skin red and peeling for days. Vel-Lido clearly has better ingredients. I use it for laser hair removal, and the results are consistent. Pro tip: wrap it in cling film to double the effect. Way better value than the tiny tubes you get at the pharmacy.
Priya Shah –
After 3 sessions with Rejuran HB , my acne scars are softer. Not overnight magic, but around week 6 I noticed my cheeks looked ‘filled in’ naturally. Hydration lasts days even in dry weather.
Chloe Bennett –
First time trying Rejuran HB after my derm recommended it. Got 5 vials from Fillersfairy. Delivery took 2 days – package had ice packs still frozen! Used it yesterday barely felt the injections thanks to the lidocaine. Skin looked instantly dewy, like I’d chugged a gallon of water. No redness or stinging afterward. Woke up today still feeling bouncy. Excited to see long-term results!