Restylane Refyne Lidocaine 1ml — OBT Technology with Premixed Lidocaine

Restylane Refyne Lidocaine 1ml is Galderma’s softest OBT / XpresHAn-Technology filler with premixed lidocaine. It contains 20 mg/mL of cross-linked hyaluronic acid and 3 mg/mL (0.3%) lidocaine. FDA approved for mid-to-deep injection into facial tissue for correction of moderate-to-severe facial wrinkles and folds, such as nasolabial folds, in patients over 21. The flexibility-focused gel structure is designed for dynamic facial zones.

The two products use identical OBT gel formulations — 20 mg/mL HA, same cross-linking, same flexibility profile. The only difference is whether 3 mg/mL (0.3%) lidocaine is premixed into the syringe. Refyne Lidocaine reduces injection-site discomfort without requiring separate anaesthesia. Refyne (without lidocaine) is selected by practitioners using topical EMLA, dental blocks, or treating patients with lidocaine sensitivity.

Both products use OBT / XpresHAn Technology and 0.3% premixed lidocaine, but differ in firmness. Refyne is softer with greater flexibility, suited to moderate folds in dynamic zones. Defyne is firmer with higher lifting capacity, suited to deep folds, marionette lines, and chin augmentation. Practitioners often select Refyne for patients with strong facial expression and moderate wrinkles, and Defyne for structural folds.

Per Galderma clinical data, Refyne Lidocaine delivers up to 12 months of correction in moderate facial wrinkles and folds. Individual duration depends on dose, placement depth, patient metabolism, and facial movement intensity. The lidocaine itself wears off within hours of injection — it does not affect long-term gel duration.

Yes. Restylane Refyne (with Lidocaine) carries FDA approval for mid-to-deep injection into facial tissue for the correction of moderate-to-severe facial wrinkles and folds, such as nasolabial folds, in patients over 21.

OBT (Optimal Balance Technology), globally branded XpresHAn Technology, is Galderma’s monophasic cross-linking process used in Restylane Refyne, Defyne, Volyme, Kysse, and Contour. It produces a smooth, integrative gel optimised for flexibility and facial expression — distinct from the firmer NASHA Technology used in classic Restylane and Restylane LYFT. Refyne is the softest member of the OBT family.

Yes — layered protocols are standard. A typical full-face plan uses Restylane LYFT for cheek volume, Restylane Defyne for deep nasolabial folds, Restylane Refyne for marionette lines and finer wrinkles, and Restylane Kysse for lips. All Restylane products share the same 20 mg/mL HA base and have established compatibility documented in Galderma clinical studies.

The Restylane Refyne syringe blister pack typically includes 30G ultra-thin wall needles. Some practitioners prefer a 30G or 27G blunt-tip cannula for delicate placement, particularly in the perioral zone or when treating patients with high bruising risk.

Restylane Refyne Lidocaine is manufactured by Q-Med AB in Uppsala, Sweden — Galderma’s biotechnology subsidiary. The product is part of the OBT / XpresHAn Technology range launched in 2016.

Store at 2-25 °C in original packaging, away from direct sunlight. Do not freeze. Shelf life is typically 24 months from manufacturing date when unopened. Once opened, contents must be used immediately — partial syringes cannot be retained for later use.