Why this product is different
Bienox is manufactured by Korea BNC (founded 2007, headquartered in Dalseo-gu, Daegu). Korea BNC operates its own botulinum toxin production line and maintains a proprietary working strain of Clostridium botulinum. Bienox is vacuum-dried — a manufacturing process that uses vacuum conditions rather than freeze-drying (lyophilization) to remove moisture. Vacuum-drying produces an ultra-thin, almost invisible powder film at the bottom of the vial rather than a visible white cake or granules. Korea BNC signed an exclusive Korean domestic distribution agreement with Dongkook Pharmaceutical in October 2024.
Mechanism of action
Botulinum toxin type A is a presynaptic neuromuscular blocker. Following injection into target muscle, the toxin’s heavy chain binds to specific receptors on motor nerve terminals; the light chain is internalised into the nerve cytoplasm, where it enzymatically cleaves SNAP-25 — a SNARE complex protein required for acetylcholine vesicle fusion at the neuromuscular junction. Without SNAP-25, acetylcholine release into the synaptic cleft is blocked, the motor nerve cannot signal the muscle fibre to contract, and the targeted muscle relaxes. New axon terminals eventually sprout and restore neuromuscular signalling, at which point clinical effect wanes.
Specifications
Category
Botulinum Toxin Type A — Korean Vacuum-dried
Manufacturer
Korea BNC (BNC Korea, Inc.)
Country of origin
Republic of Korea (Dalseo-gu, Daegu)
Strain
Clostridium botulinum proprietary working strain (Korea BNC production seed bank, strain identity not publicly disclosed)
Process
Vacuum-drying
Active ingredients
Botulinum toxin type A 100 U; human serum albumin 0.5 mg; sodium chloride 0.9 mg
Pack
1 vial × 100 U vacuum-dried powder
Storage (unopened)
2–8 °C, protected from light. Do not freeze.
Shelf life
36 months from date of manufacture (unopened, refrigerated)
After reconstitution
Use within 24 hours when stored at 2–8 °C; discard unused reconstituted product per institutional protocol
Supplied to
Licensed healthcare professionals only
Shipping
Cold-chain (2–8 °C), insulated packaging
SKU
FF-TX-BIENOX-100U
Common application zones
Application zones below are common indications for which botulinum toxin type A is used by practitioners. Specific dosing per zone is determined by the treating practitioner based on individual patient anatomy and clinical judgment.
Multi-zone single-patient sessions (multiple facial areas treated in one visit)
Bilateral masseter contouring with adjunct facial zones
Calf slimming and other body-contouring indications
Platysma bands across the full neck
Hyperhidrosis (axillary, palmar) as a therapeutic indication
Glabellar lines, forehead lines, lateral canthal lines (crow’s feet)
Contraindications
Pregnancy and lactation
Active infection at injection site
Known hypersensitivity to botulinum toxin, human albumin, or any excipient
Neuromuscular disorders (myasthenia gravis, Lambert-Eaton, ALS)
Concurrent aminoglycosides or other neuromuscular blockers
Bleeding disorders or anticoagulants without clearance
Frequently asked questions
What is Bienox 100U?
Bienox 100U is a Korean botulinum toxin type A injectable manufactured by Korea BNC. Each single-use vial contains 100 units of botulinum toxin type A as vacuum-dried powder, with 0.5 mg human serum albumin as stabilizer and 0.9 mg sodium chloride. Reconstitution is performed with 0.9% sterile saline before injection.
Who manufactures Bienox?
Bienox is manufactured by Korea BNC (BNC Korea, Inc.), a Korean pharmaceutical company founded in 2007 and headquartered in Dalseo-gu, Daegu, South Korea. Korea BNC operates its own botulinum toxin production line. The product received MFDS manufacturing and distribution approval in March 2024.
Is Bienox MFDS-approved?
Yes. Bienox received manufacturing and distribution approval from the Ministry of Food and Drug Safety (MFDS) in March 2024. The MFDS-approved indication is the temporary improvement of moderate to severe glabellar wrinkles in adults aged 19–65.
Why does the Bienox vial look empty?
Bienox is vacuum-dried. Vacuum-drying produces a much thinner product layer than freeze-drying — the vial may appear nearly empty or have only a faint translucent film at the bottom. This is normal product appearance, not a defect. Hold the vial up to bright light and tilt to see the faint film. The full 100 units of botulinum toxin type A are present and dissolve into a clear, colourless solution when reconstituted with sterile saline.
How is Bienox different from Wondertox?
Both are Korean botulinum toxin type A products. Bienox is manufactured by Korea BNC using vacuum-drying technology. Wondertox is a Chong Kun Dang brand using freeze-drying (lyophilization). The two products use different manufacturers, different production processes, and proprietary strains; units are not interchangeable across brands.
How is Bienox different from Nabota?
Both are Korean vacuum-dried botulinum toxin type A products. Nabota is manufactured by Daewoong Pharmaceutical and is FDA-approved (marketed as Jeuveau in the U.S.). Bienox is manufactured by Korea BNC and is MFDS-approved for Korean domestic and export markets. Units are not interchangeable between the two products.
What is the typical onset and duration?
Onset and duration vary with individual anatomy, muscle mass, metabolism, treatment zone, and dosing strategy. Practitioners can refer to Korea BNC product documentation and published clinical literature for general expectations specific to the indication.
What are the storage requirements?
Store unopened vials at 2–8 °C, protected from light. Do not freeze. After reconstitution with 0.9% sterile saline, use within 24 hours when stored refrigerated. Discard unused reconstituted product per institutional protocol.
What is the Korean domestic distribution arrangement?
Korea BNC signed an exclusive Korean domestic distribution agreement with Dongkook Pharmaceutical in October 2024. Dongkook handles Korean domestic distribution while Korea BNC retains export distribution rights and manufacturing.
What is the active ingredient profile?
Each Bienox 100U vial contains: Botulinum toxin type A 100 units; Human serum albumin 0.5 mg (stabilizer); Sodium chloride 0.9 mg (isotonic agent).
Amanda C. –
Used to buy Rentox, but switched to Bienox because I heard the purity is better to prevent resistance. It’s been 4 months since my treatment on my crow’s feet and it’s still holding up strong! Usually, Korean tox wears off around the 3-month mark for me. The longevity on this 100U vial is crazy good. Highly recommend if you metabolize things quickly.
Julianne Rossi –
I hate the “plastic” look. I want to be able to show emotion without my forehead looking like a roadmap. Bienox is very forgiving. It softened my glabella lines but left me with enough movement to look human. It’s much more refined than the older Meditoxin batches I’ve used in the past. It solves that “heavy eyelid” issue because it doesn’t migrate as much. Definitely my new go-to for preventative botox.
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John Carter –
Finally found a supplier that doesn’t break the bank! Ordered 15 vials of BIENOX 100u from fillersfairy – their bulk discount saved my clinic over $100 compared to others. Tracking was slick; watched the package move from warehouse to my door in real time. The product arrived ice-cold in perfect condition.