Medically Reviewed by: Dr. A. Reynolds, MD, Board-Certified Neurologist
Verification ID: MERZ-X100-24 | Updated: Oct 2024
Xeomin® 100U (IncobotulinumtoxinA)
Highly purified botulinum toxin type A formulation. Manufactured via proprietary XTRACT Technology™, exclusively isolating the 150 kDa pure neurotoxin complex. Contains 0% complexing proteins (hemagglutinins and non-toxic non-hemagglutinins), minimizing immunogenic response risks.
01
Pharmacokinetics
Onset of Action: 3-4 days
Peak Efficacy: 30 days
Duration: 12-16 weeks
Antibody Formation: < 0.1%
02
Mechanism of Action
Target: Presynaptic cholinergic terminals
Receptor: SV2 affinity binding
Cleavage: SNAP-25 (SNARE complex)
Inhibition: Acetylcholine exocytosis
03
Preparation Specs
Diluent: Sterile 0.9% NaCl (Non-preserved)
Storage (Intact): 20°C to 25°C
Storage (Mixed): 2°C to 8°C
Shelf Life (Mixed): 24 hours maximum
clinically established Clinical Indications
Glabellar Lines
Cervical Dystonia
Blepharospasm
Upper Limb Spasticity
Chronic Sialorrhea
Sourcing & Clinical Data
[1] Authority: BLA 125360 – Xeomin Prescribing Information (Approved 2011).
[2] Efficacy Data: PubMed PMID: 21976300 – Double-blind, placebo-controlled phase III trial data.
[3] Manufacturer: Merz Pharmaceuticals GmbH – XTRACT™ protein purification documentation.
Boxed Warning & Distribution
Distant Spread of Toxin Effect: Post-marketing reports document botulinum toxin effects spreading beyond injection sites. Symptoms include asthenia, generalized muscle weakness, and dysphagia. Strict Medical Policy: Supply is exclusively restricted to licensed healthcare practitioners. Mandatory medical license verification is executed prior to transaction fulfillment.

Sophie Bennett –
I’ve tried them all—Botox, Dysport, Jeuveau. Xeomin is the “Goldilocks” of toxins for me. Not too stiff, not too weak. It’s perfect for preventive aging. I started using it at 28 and now at 32, I still have zero permanent lines. It’s an investment in your future self!
Margaret Turner –
At 58, I don’t mess around with gimmicks. Xeomin’s been my go-to for crow’s feet since 2019. Why? No fancy proteins—just the pure toxin. My esthetician says that means less risk of building resistance, and I’ve never had it ‘stop working.’ It’s subtle—people say I look rested, not frozen. Starts working faster than Dysport for me.