Merz Pharma GmbH & Co. KGaA · Federal Republic of Germany; imported via Korean wholesale channel
Xeomin 100U is FDA-approved incobotulinumtoxinA manufactured by Merz Pharma in Germany. Each single-use vial contains 100 units of the 150 kDa pure neurotoxin core of botulinum toxin type A — complexing accessory proteins are removed during Merz’s proprietary XTRACT purification process. Supplied as freeze-dried (lyophilized) powder for reconstitution. Xeomin units are calibrated approximately 1:1 with Allergan Botox units per published clinical literature.
Xeomin is manufactured by Merz Pharma in Germany. This listing is the Korean-imported wholesale channel version with English labels and KFDA registration — transparent disclosure for buyers who specifically want Korean-channel inventory pricing. The active ingredient incobotulinumtoxinA, manufacturing facility, and product specifications are identical to Xeomin sold through other regional channels.
Why this product is different
Xeomin is the only major commercial botulinum toxin type A that contains only the 150 kDa pure neurotoxin core, with complexing accessory proteins removed via Merz’s proprietary XTRACT purification process. Merz characterizes this as a ‘naked’ or ‘pure’ neurotoxin design intended to minimise potential antibody formation against accessory complex proteins. Xeomin carries FDA approval for cosmetic glabellar lines (2011), cervical dystonia, blepharospasm, chronic sialorrhea in adults, and chronic sialorrhea in pediatric patients. Xeomin’s labeled shelf life is 48 months (vs 36 months for Allergan Botox) and unopened vials can be stored at room temperature (below 25 °C) per Merz labelling, eliminating the need for cold-chain handling before reconstitution.
Mechanism of action
Botulinum toxin type A is a presynaptic neuromuscular blocker. Following injection into target muscle, the toxin’s heavy chain binds to specific receptors on motor nerve terminals; the light chain is internalised into the nerve cytoplasm, where it enzymatically cleaves SNAP-25 — a SNARE complex protein required for acetylcholine vesicle fusion at the neuromuscular junction. Without SNAP-25, acetylcholine release into the synaptic cleft is blocked, the motor nerve cannot signal the muscle fibre to contract, and the targeted muscle relaxes. New axon terminals eventually sprout and restore neuromuscular signalling, at which point clinical effect wanes.
Specifications
Common application zones
Application zones below are common indications for which botulinum toxin type A is used by practitioners. Specific dosing per zone is determined by the treating practitioner based on individual patient anatomy and clinical judgment.
Contraindications
Frequently asked questions
Xeomin 100U is FDA-approved incobotulinumtoxinA manufactured by Merz Pharma in Germany. Each single-use vial contains 100 units of the 150 kDa pure neurotoxin core of botulinum toxin type A as freeze-dried powder. It is the only major commercial botulinum toxin that contains only the pure neurotoxin without complexing accessory proteins.
Xeomin is manufactured by Merz Pharma GmbH & Co. KGaA, a German pharmaceutical company. Merz uses a proprietary XTRACT purification process to isolate the 150 kDa pure neurotoxin core, removing the complexing accessory proteins that are present in most other botulinum toxin type A products.
Most botulinum toxin type A products contain the 900 kDa complex — the 150 kDa neurotoxin core plus accessory hemagglutinin and non-toxin non-hemagglutinin (NTNH) proteins. Xeomin’s XTRACT process removes these accessory proteins, leaving only the 150 kDa pure neurotoxin. Merz proposes this design may minimise potential antibody formation against accessory complex proteins, which is theorised to contribute to immunoresistance in some patients with long-term repeated exposure.
Yes. This listing is the Korean-imported wholesale channel version with English labels and KFDA registration. The active ingredient incobotulinumtoxinA, manufacturing facility (Merz Pharma in Germany), and product specifications are identical to Xeomin sold through other regional channels.
Xeomin is unique among major botulinum toxin products in that unopened vials can be stored at room temperature (below 25 °C, protected from light) per Merz labelling. Refrigeration is not required for unopened vials. This eliminates the need for cold-chain handling before reconstitution. After reconstitution, the solution should be stored at 2–8 °C and used within 24 hours.
FDA-approved indications include cosmetic glabellar lines (since 2011), cervical dystonia, blepharospasm, upper limb spasticity, chronic sialorrhea in adults, and chronic sialorrhea in pediatric patients aged 2 years and older. Off-label aesthetic uses include forehead lines, lateral canthal lines, masseter contouring, and platysma bands. Specific dosing per zone is determined by the treating practitioner.
Per published clinical literature, Xeomin units (incobotulinumtoxinA) are approximately 1:1 interchangeable with Allergan Botox units (onabotulinumtoxinA). Several head-to-head studies have demonstrated clinical equivalence at a 1:1 unit ratio for cosmetic glabellar lines. However, Xeomin units are NOT 1:1 interchangeable with Dysport units (abobotulinumtoxinA), which are calibrated independently.
Both are FDA-approved botulinum toxin type A. Xeomin is manufactured by Merz in Germany using freeze-drying and contains only the 150 kDa pure neurotoxin (XTRACT process removes complexing proteins). Dysport is manufactured by Ipsen in France/UK using vacuum-drying and includes complexing accessory proteins. Units are NOT 1:1 interchangeable between the two products.
Both are botulinum toxin type A products that contain only the 150 kDa pure neurotoxin without complexing accessory proteins. Xeomin is manufactured by Merz in Germany with US regulatory authorization. Coretox is manufactured by Medytox in Korea with KFDA authorization; US regulatory status differs. Coretox is positioned as a Korean-market alternative for practitioners who prefer a pure-neurotoxin design at Korean-market pricing.
Unopened vials can be stored at room temperature (below 25 °C), protected from light — refrigeration not required per Merz labelling. After reconstitution with 0.9% sterile saline, store at 2–8 °C and use within 24 hours. Discard any unused reconstituted product per institutional protocol.
Sophie Bennett –
I’ve tried them all—Botox, Dysport, Jeuveau. Xeomin is the “Goldilocks” of toxins for me. Not too stiff, not too weak. It’s perfect for preventive aging. I started using it at 28 and now at 32, I still have zero permanent lines. It’s an investment in your future self!
Margaret Turner –
At 58, I don’t mess around with gimmicks. Xeomin’s been my go-to for crow’s feet since 2019. Why? No fancy proteins—just the pure toxin. My esthetician says that means less risk of building resistance, and I’ve never had it ‘stop working.’ It’s subtle—people say I look rested, not frozen. Starts working faster than Dysport for me.