Why this product is different
Botulax is Hugel Pharma’s flagship botulinum toxin type A and one of the most established Korean neuromodulators by clinical volume. The CBFC26 working strain is Hugel’s proprietary lineage. Production uses freeze-drying, producing a visible white lyophilizate in the vial — distinct from vacuum-dried products that can appear empty. Hugel has built one of the largest production capacities for botulinum toxin in Korea.
Mechanism of action
Botulinum toxin type A is a presynaptic neuromuscular blocker. Following injection into target muscle, the toxin’s heavy chain binds to specific receptors on motor nerve terminals; the light chain is internalised into the nerve cytoplasm, where it enzymatically cleaves SNAP-25 — a SNARE complex protein required for acetylcholine vesicle fusion at the neuromuscular junction. Without SNAP-25, acetylcholine release into the synaptic cleft is blocked, the motor nerve cannot signal the muscle fibre to contract, and the targeted muscle relaxes. New axon terminals eventually sprout and restore neuromuscular signalling, at which point clinical effect wanes.
Specifications
Category
Botulinum Toxin Type A — Freeze-dried
Manufacturer
Hugel Pharma
Country of origin
Republic of Korea
Strain
Clostridium botulinum strain CBFC26 (Hugel proprietary working strain)
Process
Freeze-drying (lyophilization)
Active ingredients
Clostridium botulinum toxin type A, 100 units per vial. Human serum albumin (stabiliser). Sodium chloride (tonicity adjuster). Hugel CBFC26 working strain.
Pack
1 vial × 100 units. Lyophilized white powder for reconstitution with 0.9% sterile saline before injection.
Storage (unopened)
Store at 2–8 °C, protected from light. Do not freeze.
Shelf life
36 months from manufacturing date (unopened)
After reconstitution
Use within 24 hours when stored at 2–8 °C after reconstitution.
Supplied to
Licensed healthcare professionals only
Shipping
Cold-chain (2–8 °C), insulated packaging
SKU
FF-TX-BOTULAX-100U
Common application zones
Application zones below are common indications for which botulinum toxin type A is used by practitioners. Specific dosing per zone is determined by the treating practitioner based on individual patient anatomy and clinical judgment.
Glabellar lines (between the eyebrows)
Forehead lines (horizontal)
Lateral canthal lines (crow’s feet)
Masseter contouring (lower-face slimming)
Brow lift refinement
Mentalis muscle (chin)
Platysma bands (neck)
Hyperhidrosis (axillary)
Contraindications
Pregnancy and lactation
Active infection at the planned injection site
Known hypersensitivity to botulinum toxin, human albumin, or any excipient
Neuromuscular disorders (myasthenia gravis, Lambert-Eaton syndrome, ALS)
Concurrent aminoglycoside antibiotics or other neuromuscular-blocking agents
Bleeding disorders or anticoagulant therapy without medical clearance
Frequently asked questions
What is Botulax 100U?
Botulax 100U is a Korean botulinum toxin type A manufactured by Hugel Pharma. Each single-use vial contains 100 units of lyophilized white powder, reconstituted with 0.9% sterile saline before injection. Botulax is one of the most widely used Korean neuromodulators by clinical volume.
Who manufactures Botulax?
Botulax is manufactured by Hugel Pharma in the Republic of Korea. Hugel is one of the three largest botulinum toxin manufacturers in Korea (alongside Medytox and Daewoong) and operates large-scale toxin production capacity domestically.
What is the CBFC26 strain?
CBFC26 is Hugel’s proprietary Clostridium botulinum working strain used to produce Botulax. It is the genetic lineage Hugel maintains in its production seed bank. Genomic analysis published alongside Hugel’s regulatory filings has shown CBFC26 to be the same DNA sequence as the Hall ATCC 3502 reference strain widely used in botulinum toxin production globally.
Is Botulax freeze-dried or vacuum-dried?
Botulax is freeze-dried (lyophilized). After freeze-drying, a visible white powder cake or thin layer remains in the vial. This is distinct from vacuum-dried botulinum toxins which can sometimes appear empty in the vial — both are normal manufacturing processes for botulinum toxin type A products.
What is Botulax 100U commonly used for?
Common aesthetic application zones include glabellar lines (between the eyebrows), forehead lines, lateral canthal lines (crow’s feet), masseter contouring, brow lift refinement, mentalis muscle, and platysma bands. Therapeutic uses include hyperhidrosis. Specific dosing per zone is determined by the treating practitioner based on individual anatomy and clinical judgment.
How is Botulax different from Botulax 200U and 300U?
Botulax 100U is the single-vial single-patient pack — the most common format for individual aesthetic sessions. Botulax 200U is a higher-unit-count vial suited for multi-patient sessions or larger treatment areas in a single patient. Botulax 300U is the high-unit-count format for high-volume clinics and multi-zone procedures. All three share the same active ingredient and CBFC26 strain — the difference is pack size.
How is Botulax different from Nabota?
Both are Korean botulinum toxin type A products but from different manufacturers and using different production processes. Botulax is manufactured by Hugel Pharma using freeze-drying with the CBFC26 strain. Nabota is manufactured by Daewoong Pharmaceutical using vacuum-drying with a wild-type strain. Choice between them is typically based on practitioner preference and clinical experience.
How long does Botulax last?
Onset and duration vary with individual anatomy, muscle mass, metabolism, treatment zone, and dosing strategy. Practitioners can refer to published clinical literature for general expectations specific to their indication.
What are the storage requirements?
Store unopened vials at 2–8 °C, protected from light. Do not freeze. After reconstitution with 0.9% sterile saline, the solution is typically used within 24 hours when stored refrigerated. Discard any unused reconstituted product per institutional protocol.
Is Botulax 100U the same as the US Letybo product?
Letybo is the US-marketed brand name for Hugel’s botulinum toxin type A, with US distribution managed through Hugel’s US subsidiary. Both products derive from Hugel’s manufacturing platform. However, packaging, labelling, and regulatory status differ by jurisdiction. The product on Fillersfairy is the Korean-market Botulax, not the US-labelled Letybo.
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Emily R –
Ordered 10 vials of Botulax from fillersfairy last month, and the bulk discount was legit! Saved almost $20 compared to other sites. Shipping was faster than expected got tracking updates straight to my email, so I knew exactly when it’d arrive. The product Smooth reconstitution, no weird clumps, and my clients noticed faster results compared to the last brand I used.