Chaeum Premium 2 — Monophasic HA Filler for Medium Wrinkles & Lip Augmentation (2/4)

Chaeum Premium 2 is Hugel Pharma’s medium-density monophasic HA filler — 24 mg/mL cross-linked HA + 0.3% lidocaine at 2/4 cross-linking rate. Engineered for mid-dermis placement targeting moderate wrinkles, lip augmentation, and perioral lines. Endotoxin under 0.03 EU/mL, BDDE residual under 0.5 ppm. Supplied as 2 × 1.1 mL syringes per box.

Chaeum Premium 2 Hyaluronic Acid Filler is manufactured by Hugel Pharma Co. Ltd., a South Korea-based medical device and pharmaceutical company established in 2001. The product is part of the Chaeum dermal filler range, which is distributed across multiple international markets. Regulatory status: KFDA registered · GMP certified.

Chaeum Premium 2 Hyaluronic Acid Filler contains 24 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using Hugel Pharma Co. Ltd.’s Monophasic Cross-Linking (2/4 Rate) technology. Phosphate-buffered saline at near-physiological pH carries the gel.

Per Hugel Pharma Co. Ltd.’s clinical data, Chaeum Premium 2 Hyaluronic Acid Filler delivers 9–12 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Mid dermis placement typically delivers the longer end of the duration range.

Chaeum Premium 2 Hyaluronic Acid Filler is engineered for mid dermis placement. The standard recommended needle is 27G, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work.

Chaeum Premium 2 Hyaluronic Acid Filler regulatory status: KFDA registered · GMP certified. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use.

Store Chaeum Premium 2 Hyaluronic Acid Filler between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk.

No. Chaeum Premium 2 Hyaluronic Acid Filler uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation).

Yes — layered protocols combining different fillers are standard aesthetic practice. Chaeum Premium 2 Hyaluronic Acid Filler can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU.

Both share the same Hugel Pharma monophasic cross-linking technology and 24 mg/mL HA base, but differ in cross-link rate and injection depth. Premium 1 (1/4 rate) targets superficial dermis for fine lines and delicate zones. Premium 2 (2/4 rate) is for mid-dermis placement — moderate wrinkles, lip augmentation, marionette lines. Practitioners select Premium 1 for refinement work and Premium 2 for moderate-firmness correction.