Study Reference: CRN-2022-04 (In-Vivo, N=45)

• 28% increase in skin elasticity within 14 days (Evaluated via Cutometer MPA580).

• 72-hour sustained Trans-Epidermal Water Loss (TEWL) reduction.

• 94% recorded cellular fibroblast regeneration boost.

• Volume: 5 × 5ml Sterile per Kit.

• Formulation: HSA-Compatible (Human Serum Albumin substitute protocol).

• Stability: 18-Month shelf life at 15-25°C.

• pH Level: 6.8 – 7.2 (Biocompatible physiological pH).

PDRN Nucleotides

Salmon-derived DNA fragments. Stimulates A2A purinergic receptors, increasing fibroblast proliferation and down-regulating pro-inflammatory cytokines.

Pentapeptide-3

MMP-1 and MMP-3 inhibitor. Prevents enzymatic collagen degradation and supports Collagen IV synthesis at the dermal-epidermal junction.

Glutathione Isomers

L-optical active form. Directly interrupts melanogenesis by binding to copper ions within the active site of the tyrosinase enzyme.

Hyaluronic Acid

Non-crosslinked matrix utilizing 3 molecular weights (0.5 MDa, 1.2 MDa, 1.8 MDa) for multi-depth transdermal hydration.

Application Protocol

1. Prep: Cleanse target area using a non-ionic surfactant.

2. Dosage: Apply 0.3ml/cm².

3. Method: Microchanneling or micro-needling (Depth: 0.25mm – 0.5mm depending on epidermal thickness).

4. Post-Care: Immediate cryogenic cooling (-4°C) for 5 minutes.

5. Cycle: Initial trilogy spaced 2 weeks apart; maintenance q4 weeks.

Safety & Contraindications