Quick Answer
DIVA EYE PN is a Lexyal Korean specialist polynucleotide formulation for the periorbital area, supplied as a 1.1 mL syringe containing 2 mg of salmon-derived PN. Polynucleotides are long-chain DNA fragments with >95% homology to human DNA, MFDS-approved for skin regeneration. Standard course is three sessions 2–4 weeks apart, targeting periocular fine lines, dark circles, and early lower-lid laxity.
Why This Skinbooster Is Different
DIVA EYE PN is specifically optimized for the periorbital area — concentration, viscosity, and syringe volume are calibrated for ultrafine intradermal microinjection in this delicate anatomy. The pairing with DIVA FACE PN (40 mg in 2 mL) is intentional: two formulations, two anatomies. PN >95% human gene homology underlies the safety profile.
Mechanism of Action
Periocular polynucleotide (fibroblast activation, ECM restoration). Long-chain salmon DNA fragments (PN) deliver sustained fibroblast signalling. The 250–800 kDa MW range is optimal for fibroblast receptor engagement and dermal residence. In the periocular anatomy, where skin is thinnest, PN restores quality without correcting volume — the appropriate intervention for tissue quality rather than structural deficit.
Frequently Asked Questions
What is the difference between DIVA EYE PN and DIVA FACE PN?
Both are Lexyal salmon-derived PN products. DIVA EYE PN (2 mg/1.1 mL) is calibrated for the delicate periorbital area — lower concentration, smaller volume, ultrafine injection technique. DIVA FACE PN (40 mg/2 mL) is the higher-concentration full-face formulation with a denser viscosity. The two are designed to be used together in protocols treating face + eyes.
How is PN different from PDRN?
Both are DNA-derived nucleotide fragments from salmon DNA. PN (Polynucleotide) is the longer-chain form — higher molecular weight, sustained tissue residence, stronger long-term fibroblast signalling. PDRN (Polydeoxyribonucleotide) is the shorter-chain form — faster absorption, broader topical applicability. For collagen scaffold restoration, PN is generally preferred.
Why is PN appropriate for the eye area specifically?
The periorbital skin is among the thinnest on the body, with limited fibroblast density and minimal subcutaneous support. PN's mechanism — direct fibroblast activation without bulk volume addition — is well suited to this anatomy where HA filler placement risks irregularity. PN restores skin quality without correcting volume.
How is it injected around the eyes?
Multiple techniques are used: microdroplet placement along the orbital rim (10–12 points per eye, 0.05 mL each), linear threading for crow's feet (3–4 lines per quadrant), or fanning at the lateral canthus (0.05 mL aliquots at 45° angle). Ultrafine 30–32G needles are essential. Maximum 1.1 mL per session — i.e. the whole syringe.
Does it work on dark circles?
Dark circles have multiple components: pigmented (skin), vascular (visible vessels), and structural (hollow). PN addresses the skin-quality component — thinning, pigmentation from laxity, and barrier function. Vascular and structural components require additional interventions (vascular lasers, HA filler in tear trough). PN is one part of a comprehensive eye area plan.
How many sessions for visible improvement?
Initial improvement is typically reported from session 2 (around week 4). Full visible benefit appears at 8–12 weeks after the third session. Sustained results typically last 4–6 months, supporting monthly maintenance dosing during the first year of treatment.
Can it be combined with botulinum toxin for crow's feet?
Yes. PN and botulinum toxin act through entirely different mechanisms — botulinum reduces dynamic wrinkle formation by relaxing the orbicularis oculi muscle; PN improves the skin quality of the overlying tissue. Combination is widely practiced. Inject botulinum first, then PN at least 15–30 minutes later (practitioner discretion).
Is it suitable for the tear trough?
PN restores tear trough skin quality but does not correct volume. For structural tear trough hollows, HA filler is the appropriate tool. PN is sometimes layered as an adjunct to HA tear trough correction to improve overall skin texture in the area. Patient selection is critical.
Are there contraindications specific to the eye area?
Standard injectable contraindications apply: active infection (including conjunctivitis), hypersensitivity, severe coagulopathy. Pregnancy and lactation are precautionary contraindications. Patients on topical ocular medications or with severe dry eye should be evaluated case-by-case.
Does it require cold-chain shipping?
Yes. DIVA EYE PN should be maintained at 2–8 °C in transit and storage. Confirm refrigerated condition on receipt of each delivery. Brief temperature excursions are generally tolerated; prolonged warm exposure compromises PN integrity.
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