Topical Polynucleotide Serum (Microneedling Adjunct) · 2% polynucleotide (salmon-DNA, DOT™ extraction) — topical serum

Quick Answer

Rejuran Healer Trueskin Essence by PharmaResearch is a Korean polynucleotide product — 2% salmon-DNA-derived PN extracted via the proprietary DOT™ process, supplied as two 2 mL syringes. Used by practitioners for skin rejuvenation, scar improvement, and texture refinement via mesotherapy, microneedling delivery, or post-procedure application. Effect builds over a multi-session course.

Rejuran Healer Trueskin Essence delivers PharmaResearch’s proprietary DOT™-extracted polynucleotide active — the same salmon-DNA-derived PN platform behind the broader Rejuran injectable line. The 2 × 2 mL syringe format gives practitioners flexibility for mesotherapy, microneedling-channel delivery, or post-procedure application across face, neck, body, and periocular zones. PharmaResearch’s DOT™ extraction technology controls PN chain length and purity to industry benchmarks.

Polynucleotide Receptor Signalling for Dermal Regeneration. Polynucleotides are biopolymer chains of 13+ nucleotide monomers extracted from salmon DNA via the DOT™ process. Once delivered to the dermis (via mesotherapy, microneedle channels, or post-procedure absorption), PN fragments engage adenosine A2A receptors on dermal fibroblasts. Receptor activation triggers fibroblast proliferation, collagen synthesis, anti-inflammatory cytokine modulation, and skin barrier protein expression. The mechanism is biological receptor signalling.

• Skin rejuvenation and texture refinement (face, neck, body)
• Post-microneedling recovery and absorption enhancement
• Mild acne scars and post-acne hyperpigmentation
• Stretch marks and surgical scar improvement
• Periorbital dark circles (topical application)
• Mesotherapy and microneedling adjunct for professional protocols

Rejuran Healer Trueskin Essence sits in a distinct subcategory: topical PN serum. Compare with the injectable Rejuran family — Rejuran I (periocular injection), Rejuran S (acne scars), Rejuran HB (HA hybrid). Trueskin Essence is the topical alternative covering similar indications but via microneedling delivery rather than direct injection. Also compare with topical PDRN serums from other Korean brands as a category benchmark.