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5-9

$169.75

10-19

$166.25

20-Unlimited

$161.00

Juvederm Skinvive 2×1.0ml

Name: Juvederm Skinvive Injectable Gel with Lidocaine 2 x 1.0 mL
Brand: Juvederm
SKU: FF-JVDM-0ML
Price: 175 USD
Availability: InStock

HA Skinbooster · 12 mg/mL HA Vycross® + lidocaine

Quick Answer

Juvederm Skinvive by Allergan Aesthetics is the first and only FDA-approved HA microdroplet injectable for cheek smoothness — approved in May 2023 for adults aged 21 and over. Each box contains two 1.0 mL pre-filled syringes of Vycross® cross-linked HA at 12 mg/mL with 0.3% lidocaine. Known as Juvederm Volite outside the US. Single-session protocol with results lasting up to 6 months.

Last Reviewed

May 19, 2026

Manufacturer specification cross-verified

Treatment Protocol

1 session of bilateral cheek treatment. Re-treatment at 6 months for sustained results.

Why This Skinbooster Is Different

Skinvive's distinguishing feature is its FDA approval — the only HA injectable in the US category indicated for skin quality rather than volume correction. Vycross® cross-linking gives it longer dermal residence than non-crosslinked boosters, with clinical evidence supporting changes in aquaporin (skin hydration marker). In the EU it has been on market since 2017 as Volite with extensive real-world data.

Mechanism of Action

Vycross® Cross-linked HA Microdroplet Skinbooster. Stabilized HA micro-droplets are placed multi-puncture into the dermis. The HA binds water (~1000× its weight), providing sustained hydration that improves elasticity, smoothness, and dermal density. The Smart Click™ dose guide enables precise, consistent micro-dosing across the treatment field.

Specifications

Product Name	Juvederm Skinvive 2×1.0ml
Category	HA Skinbooster
Active Ingredients	12 mg/mL Vycross® cross-linked hyaluronic acid + 0.3% lidocaine + phosphate buffer (VYC-12L)
Mechanism Class	Vycross® Cross-linked HA Microdroplet Skinbooster
Manufacturer	Allergan Aesthetics (AbbVie)
Origin	Ireland (Allergan EU manufacturing)
Pack	2 × 1.0 mL pre-filled syringes
Lidocaine	0.3% (3 mg/mL) premixed
Injection Technique	Intradermal microdroplet technique across the cheek field
Injection Depth	Mid-dermis (2–3 mm)
Recommended Needle	30G ½ included; recommended technique for microdroplet placement
Treatment Protocol	1 session of bilateral cheek treatment. Re-treatment at 6 months for sustained results.
Effect Duration	Up to 6 months from a single optimal-treatment session
Storage	2–25 °C, protect from light, do not freeze
Shelf Life	24 months unopened
Regulatory	FDA-approved May 2023 for cheek smoothness in adults 21+ (PMA P170023/S028). CE-marked in EU since 2017 as Juvederm Volite. Manufactured by Allergan under ISO 13485.
SKU	FF-SB-JUVEDERM-SKINVIVE-2-1-0ML

Clinical Indications

Cheek skin smoothness (FDA-approved primary indication)
Cheek hydration and glow
Skin texture improvement on the malar region

Compare Within Skinbooster Category

Product	Active(s)	Mechanism	Protocol	Duration
Juvederm Skinvive 2×1.0ml	12 mg/mL HA Vycross® + lidocaine	Vycross® Cross-linked HA Microdroplet Skinbooster	1 session of bilateral cheek treatment. Re-treatment at 6 months for sustained results.	Up to 6 months from a single optimal-treatment session
Regenovue Aqua Shine Plus 3ml×3	15 mg/mL HA + lidocaine	Partially Cross-linked HA Skinbooster	3 sessions, 8 weeks apart. Maintenance every 6 months.	6–8 months after the initial 3-session course

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Frequently Asked Questions

What is Juvederm Skinvive 2×1.0ml?

Juvederm Skinvive (VYC-12L) is an Allergan Aesthetics HA injectable approved by the FDA in May 2023 for improving cheek skin smoothness in adults 21+. Each box contains two 1.0 mL pre-filled syringes of Vycross® cross-linked HA at 12 mg/mL with 0.3% lidocaine.

Is Skinvive the same as Juvederm Volite?

Yes — Skinvive is the US brand name; Volite is the EU brand name for the same product. Both contain VYC-12L (Vycross® cross-linked HA at 12 mg/mL with 0.3% lidocaine). Volite has been CE-marked in Europe since 2017 with extensive clinical data; Skinvive obtained US FDA PMA approval in May 2023.

How does Skinvive differ from traditional HA fillers?

Traditional Juvederm fillers like Voluma, Volift, or Vollure are designed to add structural volume to cheeks, lips, or folds. Skinvive is designed to improve skin smoothness and hydration of the cheek without adding volume — it disperses as microdroplets across the dermal field rather than as a structural bolus.

How does Vycross® cross-linking work?

Vycross® combines high and low molecular weight HA chains in a hybrid cross-linked matrix that delivers extended dermal residence with smooth tissue integration. It is Allergan's proprietary technology used across multiple Juvederm products and gives Skinvive a duration of up to 6 months from a single treatment.

Where is Skinvive injected?

FDA approval is specifically for the cheeks. The product is delivered as microdroplets across the cheek field — typically 8 to 12 injection points per side using a 30G needle at mid-dermal depth. Off-label use to the rest of the face is at the practitioner's clinical discretion.

How long do Skinvive results last?

Per Allergan's pivotal trial, 58% of patients showed ≥1-point improvement on the Allergan Cheek Smoothness Scale at 1 month, and 56% maintained ≥1-point improvement at 6 months. Duration is up to 6 months with optimal treatment. Re-treatment at 6-month intervals is the typical maintenance schedule.

Is Skinvive a filler that adds volume?

No — Skinvive is positioned by Allergan as a skin quality product, not a volumising filler. The microdroplet placement and HA concentration are calibrated for hydration and smoothness rather than structural augmentation. For volume restoration, Juvederm Voluma or Volift are the appropriate products.

Can Skinvive be combined with other Juvederm fillers?

Yes — Skinvive is commonly combined with structural Juvederm fillers in the same patient (different fields, different sessions). Voluma for cheek volume + Skinvive for cheek skin quality is a well-established protocol. Filler sessions are usually 2 weeks apart from Skinvive sessions.

What are common side effects of Skinvive?

Most common: injection-site redness, bruising, swelling, tenderness, lumps and bumps, firmness, discoloration, and itching. Effects are usually mild-moderate and resolve within 30 days. Patients should be screened for HA hypersensitivity and lidocaine allergy.

How much does Juvederm Skinvive 2×1.0ml cost?

Juvederm Skinvive 2×1.0ml is priced at USD $175.00 per 2-syringe box on Fillersfairy, with wholesale pricing for licensed practitioners.

Source verification: → Allergan Aesthetics (AbbVie) (manufacturer) · → FDA 510(k) Database (verification)

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Regulatory Notice. FDA-approved May 2023 for cheek smoothness in adults 21+ (PMA P170023/S028). CE-marked in EU since 2017 as Juvederm Volite. Manufactured by Allergan under ISO 13485. This product is manufactured outside the United States; FDA approval status is product-specific. For licensed healthcare professionals only. Practitioners are responsible for verifying regulatory status of this product in their jurisdiction before clinical use. Not for retail sale. Pricing subject to change.

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