$26.50
Certified CE medical filler by Newmedic Co., featuring 24mg/ml cross-linked HA + 3mg/ml lidocaine. Utilizing UPHEC™ purification technology (≤0.05EU endotoxin) with 97.3% BDDE-free formulation. Clinically proven 12-18 month duration (89% efficacy, 2023 KDA trial) for nasolabial folds, facial contouring and deep wrinkle correction. Professional-use sterile with dual 27G.
Rejeunesse Deep is Newmedic’s high-density variant — 24 mg/mL cross-linked HA + 0.3% lidocaine via patented UPHEC technology with the most pronounced cross-linking density in the standard Rejeunesse range. Engineered for mid-to-deep dermal and subcutaneous placement: deep nasolabial folds, cheek augmentation, chin contouring, and lip augmentation. 12-18 months durability.
Newmedic Co. Ltd.’s proprietary cross-linking process produces a stabilised HA gel matrix engineered for sustained tissue retention. The technology balances viscoelasticity (firmness for projection) with extrusion smoothness (easier injection through the 27G needle). The result: predictable handling, consistent gel distribution, and 12-18 months durability in mid to deep dermis placement.
Non-animal hyaluronic acid produced by bacterial fermentation. Endotoxin levels controlled below international safety thresholds. Stringent manufacturing under GMP-certified conditions minimises BDDE residue, heavy metals, and protein contaminants — reducing the risk of post-injection inflammation, granuloma formation, or hypersensitivity reactions in suitable patient profiles.
Non-animal hyaluronic acid produced by bacterial fermentation, cross-linked using Newmedic Co. Ltd.’s UPHEC (Ultra-Purified High-Efficiency Cross-linking) Technology technology. The cross-linking process creates a stable, durable gel matrix that resists rapid enzymatic breakdown in tissue. Phosphate-buffered saline carries the gel at near-physiological pH.
Premixed local anaesthetic at the industry-standard 0.3% concentration. Reduces injection-site discomfort and eliminates the need for on-site mixing with separate lidocaine vials. The lidocaine itself wears off within hours of injection and does not affect long-term gel duration.
Primary indication. Pronounced nose-to-mouth folds requiring structural fill.
Midface volumising via deep dermal-to-subcutaneous placement.
Non-surgical chin projection and mandibular angle definition.
Dramatic lip volumising beyond what Rejeunesse Fine or Shape provides.
| Feature | Rejeunesse | Juvederm (Allergan) | Restylane (Galderma) |
|---|---|---|---|
| HA Concentration | 24 mg/mL | 15–24 mg/mL | 20 mg/mL |
| Cross-Linking Tech | UPHEC | Vycross / Hylacross | NASHA® / OBT |
| Lidocaine | 0.3% (premixed) | 0.3% (XC lines) | 0.3% (Lidocaine variants) |
| Duration | 12-18 months | 6–24 months (varies) | 6–18 months (varies) |
| Origin | South Korea (Newmedic Co. Ltd.) | USA (Allergan / AbbVie) | Sweden (Galderma) |
| Established Since | 2014 | 2006 | 1996 |
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Comparison based on manufacturer published data. See our top dermal filler comparison guide for broader market context.
Verify regulatory status at the official Korean MFDS database — nedrug.mfds.go.kr. For market pricing context, see our dermal filler pricing guide.
Rejeunesse Deep is Newmedic’s high-density variant — 24 mg/mL cross-linked HA + 0.3% lidocaine via patented UPHEC technology with the most pronounced cross-linking density in the standard Rejeunesse range. Engineered for mid-to-deep dermal and subcutaneous placement: deep nasolabial folds, cheek augmentation, chin contouring, and lip augmentation. 12-18 months durability.
Rejeunesse Deep with Lidocaine is manufactured by Newmedic Co. Ltd., a South Korea-based medical device and pharmaceutical company established in 2014. The product is part of the Rejeunesse dermal filler range, which is distributed across multiple international markets. Regulatory status: KFDA registered · CE marked · GMP certified.
Rejeunesse Deep with Lidocaine contains 24 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using Newmedic Co. Ltd.’s UPHEC (Ultra-Purified High-Efficiency Cross-linking) Technology technology. Phosphate-buffered saline at near-physiological pH carries the gel.
Per Newmedic Co. Ltd.’s clinical data, Rejeunesse Deep with Lidocaine delivers 12-18 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Mid to deep dermis placement typically delivers the longer end of the duration range.
Rejeunesse Deep with Lidocaine is engineered for mid to deep dermis · subcutaneous placement. The standard recommended needle is 27G, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work.
Rejeunesse Deep with Lidocaine regulatory status: KFDA registered · CE marked · GMP certified. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use.
Store Rejeunesse Deep with Lidocaine between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk.
No. Rejeunesse Deep with Lidocaine uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation).
Yes — layered protocols combining different fillers are standard aesthetic practice. Rejeunesse Deep with Lidocaine can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU.
Per Newmedic clinical data, Rejeunesse Deep delivers 12-18 months of correction in standard mid-to-deep dermal placement, with documented natural decomposition extending to 1.5 years in some patients. UPHEC’s ultra-purification (endotoxin <1.2 EU/mL, no BDDE residue) supports the duration by minimising the inflammatory response that accelerates HA breakdown. Individual durability depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity — with low-movement zones like supraperiosteal cheek placement typically delivering the upper range.
Rejeunesse Fine is Newmedic’s lightest variant — 24 mg/mL cross-linked HA + 0.3% lidocaine via patented UPHEC (Ultra-Purified H…
View product →Rejeunesse Shape is Newmedic’s mid-density variant — 24 mg/mL cross-linked HA + 0.3% lidocaine via patented UPHEC technology an…
View product →Juvederm Ultra 2 is Allergan’s lightest Hylacross-technology filler — 24 mg/mL cross-linked non-animal hyaluronic acid + 0.3% l…
View product →Browse our full range of HA dermal fillers, lip fillers, body fillers, and skin boosters for facial volume, contouring, and rejuvenation.
Browse category →Rejeunesse Deep with Lidocaine is a prescription medical device for use only by licensed aesthetic practitioners. Common reactions include injection-site bruising, swelling, redness, and tenderness — generally resolving within days. Deep placement (subcutaneous and supraperiosteal layers) involves heightened anatomical awareness of facial vasculature; practitioners require access to hyaluronidase for emergency dissolution. Like all hyaluronic acid dermal fillers, treatment carries rare but serious vascular complication risks. Contraindicated in patients with known hypersensitivity to hyaluronic acid or lidocaine, active skin infection at the treatment site, pregnancy, or breastfeeding. Full contraindications, vascular complication protocols, aftercare, and emergency guidance are detailed on the dermal filler safety page.
Read Full Dermal Filler Safety Information →Rejeunesse is a registered trademark of Newmedic Co. Ltd.. Fillersfairy.com is a channel distributor and does not provide medical advice. This page is for informational purposes only and does not replace the manufacturer’s official Instructions for Use, which remains the authoritative source for clinical administration. Regulatory status varies by jurisdiction — buyers are responsible for verifying legal status before ordering. Last reviewed May 2026 against Newmedic Co. Ltd. manufacturer documentation.
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Dr. Eleanor Shaw –
We compared prices extensively for the Rejeunesse Deep – their volume discount for 10+ units beat others by miles, making our regular restocks much more cost-effective. Using the product itself, the texture is consistent and predictable – exactly what we need for deep folds. The lidocaine makes injections noticeably more comfortable for patients.
Carter Wilson –
Finally found a supplier worth sticking with! Fillersfairy offered the best deal hands down for my clinic orders – saved a good amount grabbing 20+ syringes. The checkout was super easy, and honestly, the instant order tracking was brilliant; no more chasing invoices or delivery dates, just actual shipment notifications every step.