SM Cream 10.56% Lidocaine 500g – Professional-Grade Topical Numbing Cream
Fast 10–12 Minute Onset – Validated Across Fitzpatrick Skin Types II–VI
SM Cream 10.56% Lidocaine is a medical-grade topical anesthetic engineered with 10.56% pharmaceutical-grade lidocaine HCl, pH-balanced to 6.2–6.8. Under occlusion, analgesia onset begins in just 10–12 minutes, with therapeutic effect lasting 90±15 minutes. This batch-controlled formulation demonstrates a less than 1% irritation rate across Fitzpatrick skin types II–VI (n=1000), and is supplied in a USP <797>-compliant 500g HDPE jar with aluminum seal, yielding 250+ applications for high-volume clinical use.
Indicated Procedures
Laser Resurfacing Validated for laser resurfacing procedures up to 1064nm wavelength.
Microneedling Suitable for microneedling at 0.5–3mm penetration depths.
Dermal Filler Administration Fast 10–12 minute onset suits quick pre-injection numbing.
High-Volume Clinic Use 500g jar yields 250+ applications, suited to busy daily schedules.
Clinical Specifications
| Active Ingredient (API) | 10.56% Lidocaine HCl |
| pH Level | 6.2 – 6.8 |
| Onset Time | 10 – 12 minutes (with occlusion) |
| Therapeutic Duration | 90 ± 15 minutes |
| Irritation Rate | <1% (Fitzpatrick II–VI, n=1000) |
| Shelf Life | 30 months |
| Yield / Packaging | 500g HDPE jar with aluminum seal – 250+ applications |
| Storage Compliance | USP <797> compliant HDPE jars |
How to Use
- Apply: Apply 2.5mg/cm² to the stratum corneum, covering the treatment area evenly.
- Occlude: Cover with polyethylene film to support the 10–12 minute onset window.
- Wait: Remove after 20 minutes (maximum 25 minutes).
- Cleanse: Cleanse the target area thoroughly with sterile saline solution.
- Proceed: Begin the procedure once the area is clean and anesthesia is confirmed.
Frequently Asked Questions
Why is SM Cream’s onset rated at 10–12 minutes, faster than some other 10.56% lidocaine creams?
All 10.56% lidocaine creams share the same active ingredient concentration, but onset speed depends heavily on the emulsion base, pH targeting, and how readily the formula penetrates the stratum corneum under occlusion. SM Cream is formulated and pH-balanced (6.2–6.8) specifically to support rapid absorption with polyethylene film occlusion, which is why its rated onset (10–12 minutes) is on the faster end compared to other 10.56% formulations in the catalog that are optimized for slightly different protocols (15–20 minutes). The 90±15 minute duration that follows is comparable in range to those other products.
What does “<1% irritation rate across Fitzpatrick II–VI (n=1000)” actually mean?
The Fitzpatrick scale classifies skin types from I (very fair) to VI (deeply pigmented) based on how skin responds to UV exposure, and it is commonly used in dermatology to describe the diversity of skin types tested in a clinical or batch-validation sample. A “<1% irritation rate across Fitzpatrick II–VI (n=1000)” means that in a sample of 1,000 applications spanning that range of skin types, fewer than 1% showed an irritation response. This is intended to give practitioners a sense of how the formula performs across a broad range of skin tones and sensitivities, not a guarantee for any individual patient – a patch test is still recommended.
What does “USP <797> compliant HDPE jars” mean for storage?
USP <797> is a United States Pharmacopeia chapter that sets standards for the preparation, handling, and storage of compounded sterile products to minimize contamination risk. Packaging this cream in HDPE (high-density polyethylene) jars that meet USP <797> storage guidance means the container material and seal are chosen to maintain product sterility and stability over the 30-month shelf life, provided the jar is stored correctly (cool, dry, away from direct heat) and the seal remains intact until first use.
How does the 500g jar yield “250+ applications” – what’s the math behind that?
The application rate is 2.5mg/cm² of 10.56% lidocaine cream. A small treatment area – for example a single injection site or a localized laser spot roughly the size of a couple of square centimeters – uses only a small fraction of a gram per application. Scaling 500g of product across many small, localized applications at this density works out to roughly 250 or more individual treatment applications, which is why the jar is positioned for high-frequency clinical use rather than single full-body sessions.
Why is this product specifically validated for laser resurfacing up to 1064nm?
1064nm corresponds to the wavelength used by Nd:YAG-type lasers, which are commonly used for deeper resurfacing, pigment, and vascular treatments and can cause more discomfort than shorter-wavelength devices due to deeper tissue interaction. Listing 1064nm as the upper validated range signals that this cream’s 10–12 minute onset and 90±15 minute duration are intended to provide adequate numbing coverage for the duration of these deeper, often longer resurfacing sessions, in addition to shorter-wavelength or more superficial laser work.
⚠ Safety Information & Contraindications
Contraindications - Mucous membranes, ocular regions, or nasal passages – absolute contraindication
- Known hypersensitivity to amide-type local anesthetics
Stop Use If You Notice - Redness, swelling, or rash beyond mild blanching
- Blistering or broken skin at the application site
- Signs of systemic reaction (dizziness, irregular heartbeat)
Neural sensitivity patch test required prior to full application. For professional use only. This product is not a substitute for medical advice.
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