Sosum M — LTSR HA Filler for Moderate Wrinkles & Lip Enhancement (2 x 1ml)
Sosum M is JSBIO’s medium-density variant — 20 mg/mL cross-linked HA via patented LTSR technology with G’ >250Pa. Lidocaine-free formulation. Engineered for mid-dermal placement targeting nasolabial folds, marionette lines, lip augmentation, and forehead wrinkles. Zero residual BDDE through two-step purification. 2 x 1 mL pack.
Manufacturer: JSBIO Co. Ltd., South Korea · Established 2013
How Sosum M Moderate Wrinkles Dermal Filler Is Engineered
Low-Temperature Stabilization Reaction Technology
JSBIO Co. Ltd.’s proprietary cross-linking process produces a stabilised HA gel matrix engineered for sustained tissue retention. The technology balances viscoelasticity (firmness for projection) with extrusion smoothness (easier injection through the 27G + JBP nanoneedles needle). The result: predictable handling, consistent gel distribution, and Up to 12 months durability in mid dermis placement.
Quality & Purity
Non-animal hyaluronic acid produced by bacterial fermentation. Endotoxin levels controlled below international safety thresholds. Stringent manufacturing under GMP-certified conditions minimises BDDE residue, heavy metals, and protein contaminants — reducing the risk of post-injection inflammation, granuloma formation, or hypersensitivity reactions in suitable patient profiles.
Sosum M Moderate Wrinkles Dermal Filler Active Ingredients
Cross-Linked Hyaluronic Acid
Non-animal hyaluronic acid produced by bacterial fermentation, cross-linked using JSBIO Co. Ltd.’s Low-Temperature Stabilization Reaction Technology technology. The cross-linking process creates a stable, durable gel matrix that resists rapid enzymatic breakdown in tissue. Phosphate-buffered saline carries the gel at near-physiological pH.
Lidocaine HCl
Premixed local anaesthetic at the industry-standard 0.3% concentration. Reduces injection-site discomfort and eliminates the need for on-site mixing with separate lidocaine vials. The lidocaine itself wears off within hours of injection and does not affect long-term gel duration.
Where Sosum M Moderate Wrinkles Dermal Filler Is Used
Nasolabial Folds
Primary indication. Moderate nose-to-mouth folds via mid-dermal injection.
Lip Augmentation
Lip body volumising and contour enhancement. The medium-density gel balances structure with mobility.
Marionette Lines
Oral commissure-to-jaw furrows. The 27G needle suits this zone.
Forehead & Frown Lines
Moderate horizontal forehead lines and glabella creases requiring more structure than Sosum S provides.
Sosum M Moderate Wrinkles Dermal Filler vs Juvederm vs Restylane
| Feature | Sosum | Juvederm (Allergan) | Restylane (Galderma) |
|---|---|---|---|
| HA Concentration | 20 mg/mL | 15–24 mg/mL | 20 mg/mL |
| Cross-Linking Tech | LTSR | Vycross / Hylacross | NASHA® / OBT |
| Lidocaine | 0.3% (premixed) | 0.3% (XC lines) | 0.3% (Lidocaine variants) |
| Duration | Up to 12 months | 6–24 months (varies) | 6–18 months (varies) |
| Origin | South Korea (JSBIO Co. Ltd.) | USA (Allergan / AbbVie) | Sweden (Galderma) |
| Established Since | 2013 | 2006 | 1996 |
↔ Swipe horizontally on mobile to view all columns
Comparison based on manufacturer published data. See our top dermal filler comparison guide for broader market context.
Sosum M Moderate Wrinkles Dermal Filler Product Specifications
Manufacturer
- Brand: Sosum
- Company: JSBIO Co. Ltd.
- Country: South Korea
- Established: 2013
Formula
- HA Source: Non-animal bacterial fermentation
- HA Concentration: 20 mg/mL
- Lidocaine: 0.3% (3 mg/mL) premixed
- Cross-linking: Low-Temperature Stabilization Reaction Technology
Performance
- Duration: Up to 12 months
- Injection Depth: Mid dermis
- Recommended Needle: 27G + JBP nanoneedles
- Last Reviewed: May 2026
Approval & Storage
- Approvals: MFDS approval 2013 · CE certified · GMP
- Packaging: 2 x 1 mL syringes + JBP nanoneedles
- Storage: 2–25 °C, do not freeze
- Shelf life: 24 months unopened
Verify regulatory status at the official Korean MFDS database — nedrug.mfds.go.kr. For market pricing context, see our dermal filler pricing guide.
Sosum M Moderate Wrinkles Dermal Filler — Frequently Asked Questions
What is Sosum M Moderate Wrinkles Dermal Filler?
Sosum M is JSBIO’s medium-density variant — 20 mg/mL cross-linked HA via patented LTSR technology with G’ >250Pa. Lidocaine-free formulation. Engineered for mid-dermal placement targeting nasolabial folds, marionette lines, lip augmentation, and forehead wrinkles. Zero residual BDDE through two-step purification. 2 x 1 mL pack.
Where is Sosum M Moderate Wrinkles Dermal Filler manufactured?
Sosum M Moderate Wrinkles Dermal Filler is manufactured by JSBIO Co. Ltd., a South Korea-based medical device and pharmaceutical company established in 2013. The product is part of the Sosum dermal filler range, which is distributed across multiple international markets. Regulatory status: MFDS approval 2013 · CE certified · GMP.
What is the HA concentration in Sosum M Moderate Wrinkles Dermal Filler?
Sosum M Moderate Wrinkles Dermal Filler contains 20 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using JSBIO Co. Ltd.’s Low-Temperature Stabilization Reaction Technology technology. Phosphate-buffered saline at near-physiological pH carries the gel.
How long do Sosum M Moderate Wrinkles Dermal Filler results last?
Per JSBIO Co. Ltd.’s clinical data, Sosum M Moderate Wrinkles Dermal Filler delivers Up to 12 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Mid dermis placement typically delivers the longer end of the duration range.
What is the recommended injection depth for Sosum M Moderate Wrinkles Dermal Filler?
Sosum M Moderate Wrinkles Dermal Filler is engineered for mid dermis placement. The standard recommended needle is 27G + JBP nanoneedles, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work.
Is Sosum M Moderate Wrinkles Dermal Filler FDA approved or CE marked?
Sosum M Moderate Wrinkles Dermal Filler regulatory status: MFDS approval 2013 · CE certified · GMP. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use.
How should Sosum M Moderate Wrinkles Dermal Filler be stored at the clinic?
Store Sosum M Moderate Wrinkles Dermal Filler between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk.
Does Sosum M Moderate Wrinkles Dermal Filler contain animal-derived ingredients?
No. Sosum M Moderate Wrinkles Dermal Filler uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation).
Can Sosum M Moderate Wrinkles Dermal Filler be combined with other dermal fillers in the same session?
Yes — layered protocols combining different fillers are standard aesthetic practice. Sosum M Moderate Wrinkles Dermal Filler can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU.
Which Sosum variant is best for first-time filler patients?
Sosum M is often the default starting point for first-time Sosum patients — its medium density via LTSR technology suits the most common aesthetic concerns (nasolabial folds, moderate wrinkles, lip contouring) without the structural projection of Sosum H or Hard. The 12-month durability allows patients to assess long-term satisfaction before committing to the deeper-grade variants. The lidocaine-free formulation also lets practitioners adjust anaesthesia protocols to first-time patient tolerance.
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Browse category →Read Before Clinical Use
Sosum M Moderate Wrinkles Dermal Filler is a prescription medical device for use only by licensed aesthetic practitioners. Common reactions include injection-site bruising, swelling, redness, and tenderness — generally resolving within days. Like all hyaluronic acid dermal fillers, treatment carries rare but serious vascular complication risks. Contraindicated in patients with known hypersensitivity to hyaluronic acid or lidocaine, active skin infection at the treatment site, pregnancy, or breastfeeding. Full contraindications, vascular complication protocols, aftercare, and emergency guidance are detailed on the dermal filler safety page.
Read Full Dermal Filler Safety Information →Sosum is a registered trademark of JSBIO Co. Ltd.. Fillersfairy.com is a channel distributor and does not provide medical advice. This page is for informational purposes only and does not replace the manufacturer’s official Instructions for Use, which remains the authoritative source for clinical administration. Regulatory status varies by jurisdiction — buyers are responsible for verifying legal status before ordering. Last reviewed May 2026 against JSBIO Co. Ltd. manufacturer documentation.

Marcus Reed –
Restocking Sosum M was a breeze thanks to fillersfairy’s real-time shipping alerts. Refrigerated packaging means it arrives cold every time. In terms of treatment, the injections went smoothly, and patients raved about the minimal downtime. For nasolabial folds, it lasted as long as top brands, but at half the price.
Sophie Kim –
Fillersfairy delivered Sosum M in a week. One customer used it to treat marionette lines, and the gel was thick but evenly distributed. Swelling was minimal, and after the second week, her lower face looked very natural.