Why this product is different
Coretox is the second commercial botulinum toxin type A product worldwide that contains only the 150 kDa pure neurotoxin core, with complexing accessory proteins removed during manufacturing. (Merz Xeomin is the first such product, manufactured in Germany.) Coretox received MFDS (formerly KFDA) approval in South Korea in 2016 for glabellar lines, with subsequent indication for upper limb spasticity after stroke. Long-term safety and efficacy of repeat treatment was evaluated in a Phase IV clinical trial (NCT04281745, Medy-Tox). Coretox is manufactured by Medytox Inc. in South Korea — the same manufacturer as Meditoxin (Neuronox) and Innotox. All three products share the Hall A-hyper working strain (KAIST lineage), but Coretox alone removes the complexing accessory proteins. Additionally, Coretox’s manufacturing process does not use animal-derived raw materials, addressing a differentiation point for clinicians and patients with specific religious, dietary, or allergic concerns.
Mechanism of action
Botulinum toxin type A is a presynaptic neuromuscular blocker. Following injection into target muscle, the toxin’s heavy chain binds to specific receptors on motor nerve terminals; the light chain is internalised into the nerve cytoplasm, where it enzymatically cleaves SNAP-25 — a SNARE complex protein required for acetylcholine vesicle fusion at the neuromuscular junction. Without SNAP-25, acetylcholine release into the synaptic cleft is blocked, the motor nerve cannot signal the muscle fibre to contract, and the targeted muscle relaxes. New axon terminals eventually sprout and restore neuromuscular signalling, at which point clinical effect wanes.
Specifications
Category
Botulinum Toxin Type A — Pure Neurotoxin (no complexing proteins)
Manufacturer
Medytox Inc.
Country of origin
Republic of Korea
Strain
Clostridium botulinum Hall A-hyper strain (KAIST lineage) — 150 kDa pure neurotoxin core, complex proteins removed
Process
Freeze-drying (lyophilization)
Active ingredients
Botulinum toxin type A 100 U (150 kDa pure neurotoxin core); no complexing accessory proteins; no animal-derived raw materials in production
Pack
1 vial × 100 U freeze-dried (lyophilized) powder
Storage (unopened)
2–8 °C, protected from light. Do not freeze.
Shelf life
36 months from date of manufacture (unopened, refrigerated)
After reconstitution
Use within 24 hours when stored at 2–8 °C; discard unused reconstituted product per institutional protocol
Supplied to
Licensed healthcare professionals only
Shipping
Cold-chain (2–8 °C), insulated packaging
SKU
FF-TX-CORETOX-100U
Common application zones
Application zones below are common indications for which botulinum toxin type A is used by practitioners. Specific dosing per zone is determined by the treating practitioner based on individual patient anatomy and clinical judgment.
Multi-zone single-patient sessions (multiple facial areas treated in one visit)
Bilateral masseter contouring with adjunct facial zones
Calf slimming and other body-contouring indications
Platysma bands across the full neck
Hyperhidrosis (axillary, palmar) as a therapeutic indication
Glabellar lines, forehead lines, lateral canthal lines (crow’s feet)
Contraindications
Pregnancy and lactation
Active infection at injection site
Known hypersensitivity to botulinum toxin, human albumin, or any excipient
Neuromuscular disorders (myasthenia gravis, Lambert-Eaton, ALS)
Concurrent aminoglycosides or other neuromuscular blockers
Bleeding disorders or anticoagulants without clearance
Frequently asked questions
What is Coretox 100U?
Coretox 100U is Medytox Inc.’s pure-neurotoxin botulinum toxin type A in single-vial single-use pack. Each vial contains 100 units of the 150 kDa pure neurotoxin core, with complexing accessory proteins removed during manufacturing. Coretox is freeze-dried (lyophilized) powder for reconstitution with 0.9% sterile saline.
Who manufactures Coretox?
Coretox is manufactured by Medytox Inc., a South Korean biopharmaceutical company. Medytox also manufactures Meditoxin (Neuronox) and Innotox. All three products share Medytox’s Hall A-hyper working strain (KAIST lineage), but Coretox is differentiated by its pure-neurotoxin formulation.
What does ‘pure neurotoxin’ or ‘protein-free’ mean for Coretox?
Most botulinum toxin type A products contain the 900 kDa complex — the 150 kDa neurotoxin core plus accessory hemagglutinin and non-toxin non-hemagglutinin (NTNH) proteins. Coretox’s manufacturing process removes these accessory proteins, leaving only the 150 kDa pure neurotoxin. This design is proposed to minimise potential antibody formation against accessory complex proteins.
Does Coretox use animal-derived materials?
No. Coretox’s manufacturing process does not use animal-derived raw materials. This addresses differentiation points for clinicians and patients with religious, dietary, or allergic concerns regarding animal-derived materials in pharmaceuticals.
How is Coretox different from Xeomin?
Both Coretox and Xeomin contain only the 150 kDa pure neurotoxin without complexing accessory proteins. Xeomin is manufactured by Merz in Germany with US regulatory authorization. Coretox is manufactured by Medytox in Korea with KFDA authorization; US regulatory status differs. Coretox is positioned as a Korean-market alternative for practitioners who prefer a pure-neurotoxin design at Korean-market pricing.
How is Coretox different from Meditoxin?
Both are manufactured by Medytox Inc. using the same Hall A-hyper working strain. Meditoxin (Neuronox) contains the full 900 kDa botulinum toxin type A complex (neurotoxin plus complexing accessory proteins) with conventional excipients. Coretox contains only the 150 kDa pure neurotoxin without complexing proteins, and its manufacturing process avoids animal-derived materials.
How is Coretox different from Innotox?
Both are manufactured by Medytox Inc. Coretox contains the 150 kDa pure neurotoxin as a freeze-dried lyophilized powder requiring reconstitution. Innotox is a ready-to-use liquid formulation containing the standard botulinum toxin complex (no reconstitution required). They serve different clinical workflows.
What is Coretox commonly used for?
Common aesthetic application zones include glabellar lines, forehead lines, lateral canthal lines, masseter contouring, mentalis muscle, and platysma bands. The pure-neurotoxin formulation is particularly considered for patients with suspected immunoresistance to traditional complex-containing botulinum toxin products. Specific dosing per zone is determined by the treating practitioner.
How long does Coretox last?
Onset and duration vary with individual anatomy, muscle mass, metabolism, treatment zone, and dosing strategy. Practitioners can refer to published clinical literature for general expectations.
What are the storage requirements?
Store unopened vials at 2–8 °C, protected from light. Do not freeze. After reconstitution with 0.9% sterile saline, use within 24 hours when stored refrigerated. Discard any unused reconstituted product per institutional protocol.
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Lisa Taylor –
Honestly, I’d shopped around a few online stores, but fillersfairy blew them out with better prices and guaranteed legit products.Using it on clients, the serum reconstituted so smoothly, and patients loved how painless the injections felt right off. Silky skin that lasts ages, with barely any redness.