Maypharm Co., Ltd. · Republic of Korea
Metox 100U by Maypharm Co., Ltd. is a vacuum-dried botulinum toxin type A. Each single-use vial contains 100 units of Clostridium botulinum from Maypharm’s production platform. Maypharm is a Korean pharmaceutical company that operates a dedicated botulinum toxin production line. The 100-unit single-vial format is the most common pack size for individual aesthetic sessions.
This product is vacuum-dried. The vial may appear nearly empty before reconstitution — this is normal product appearance, not a defect. The full dose is present and dissolves into a clear, colourless solution when reconstituted with sterile saline.
Why this product is different
Metox is manufactured by Maypharm Co., Ltd., a Korean pharmaceutical company that operates its own botulinum toxin production facility. Maypharm maintains a proprietary working strain of Clostridium botulinum in its production seed bank. The vacuum-drying manufacturing process produces a thinner, less-visible product layer in the vial than freeze-drying — the vial may appear nearly empty, which is normal product appearance, not a defect. Metox is positioned as a cost-efficient Korean vacuum-dried botulinum toxin type A option.
Mechanism of action
Botulinum toxin type A is a presynaptic neuromuscular blocker. Following injection into target muscle, the toxin’s heavy chain binds to specific receptors on motor nerve terminals; the light chain is internalised into the nerve cytoplasm, where it enzymatically cleaves SNAP-25 — a SNARE complex protein required for acetylcholine vesicle fusion at the neuromuscular junction. Without SNAP-25, acetylcholine release into the synaptic cleft is blocked, the motor nerve cannot signal the muscle fibre to contract, and the targeted muscle relaxes. New axon terminals eventually sprout and restore neuromuscular signalling, at which point clinical effect wanes.
Specifications
Common application zones
Application zones below are common indications for which botulinum toxin type A is used by practitioners. Specific dosing per zone is determined by the treating practitioner based on individual patient anatomy and clinical judgment.
Contraindications
Frequently asked questions
Metox 100U is a vacuum-dried Korean botulinum toxin type A manufactured by Maypharm Co., Ltd. Each single-use vial contains 100 units of botulinum toxin type A, reconstituted with 0.9% sterile saline before injection.
Metox is manufactured by Maypharm Co., Ltd. in the Republic of Korea. Maypharm operates its own dedicated botulinum toxin production line.
Metox uses vacuum-drying as the manufacturing process. Vacuum-drying produces a much thinner product layer than freeze-drying — the vial may appear nearly empty or have only a faint dried film, which is normal and not a defect. The full 100 units of botulinum toxin type A are present and dissolve when reconstituted with sterile saline.
Common aesthetic application zones include glabellar lines, forehead lines, lateral canthal lines, masseter contouring, brow lift refinement, mentalis muscle, and platysma bands. Therapeutic uses include hyperhidrosis. Specific dosing per zone is determined by the treating practitioner.
Metox 100U is the single-vial single-patient pack. Metox 200U is a higher-unit-count vial for multi-patient sessions or larger treatment areas. Both share the same Maypharm proprietary working strain and vacuum-drying process.
Both are Korean botulinum toxin type A products from different manufacturers using different manufacturing processes. Metox is manufactured by Maypharm using vacuum-drying. Botulax is manufactured by Hugel Pharma using freeze-drying with Hugel’s proprietary working strain.
Both are vacuum-dried Korean botulinum toxin type A products from different manufacturers. Metox is manufactured by Maypharm. Nabota is manufactured by Daewoong Pharmaceutical.
Both are vacuum-dried Korean botulinum toxin type A products from different manufacturers. Metox is manufactured by Maypharm. Toxta is manufactured by JETEMA Co., Ltd. (KOSDAQ-listed Korean biopharmaceutical company).
Onset and duration vary with individual anatomy, muscle mass, metabolism, treatment zone, and dosing strategy.
Store unopened vials at 2–8 °C, protected from light. Do not freeze. After reconstitution with 0.9% sterile saline, use within 24 hours when stored refrigerated.

Kenji Sato –
I bought Metox mainly for hyperhidrosis. I tried Hengli before, but the diffusion was too messy. Metox is very precise and stays where you put it. After splitting 100u, I stayed dry all summer. The packaging design is much more scientific than older models, with excellent sealing.
Amanda Lewis –
I was worried about building resistance since I get tox regularly. A friend recommended Metox because it has high purity. Worked like a charm on my crow’s feet and it didn’t give me that “frozen” look. Shipping from Fillersfairy was super fast too. Will buy again.
Sarah –
Been using Metox 100u for 6 months in my aesthetics practice. The 48-hour onset is NO joke – clients text me selfies by day 3 showing lifted brows. For masseter reduction, 35U/side lasts exactly 5 months (tracked 23 cases). Bonus: The 2-8°C storage works perfectly in our med fridge.