Quick Answer
AMI NAD+ is a Korean multi-active mesotherapy concentrate combining NAD+, its precursor NMN, salmon-derived PDRN, niacinamide, and adenosine in a single formulation, supplied as 3 × 5 mL vials. The architecture pairs cellular energy restoration (NAD+/NMN) with DNA repair signalling (PDRN) and anti-inflammatory/barrier support (niacinamide, adenosine). Three-session course at 2–3 week intervals.
Why This Skinbooster Is Different
Where Puri Heal Revital NAD+ is a NAD+/NMN-only formulation and NadReju pairs NAD+ with PDRN, AMI NAD+ combines NAD+/NMN/PDRN with two additional barrier-and-anti-inflammatory actives (niacinamide and adenosine). This makes it a more comprehensive single-vial cocktail at the cost of being a more complex formulation.
Mechanism of Action
NAD+ multi-active cocktail (cellular energy + DNA repair). NAD+ is a coenzyme required for ATP production, DNA repair (PARP), and sirtuin pathway regulation. Skin NAD+ declines with age. Intradermal NAD+/NMN delivery replenishes the cellular currency that downstream regenerative pathways (collagen synthesis, fibroblast migration) depend on. The mechanism is upstream — supporting, not replacing, other regenerative actives.
Frequently Asked Questions
How is AMI NAD+ different from Puri Heal Revital NAD+?
Both contain NAD+ and NMN. AMI NAD+ adds PDRN (DNA repair signalling), niacinamide (barrier and pigment regulation), and adenosine (anti-inflammatory). Puri Heal Revital NAD+ is the cleaner NAD+/NMN-only formulation. AMI NAD+ is more comprehensive at one vial; Puri Heal is simpler and more focused.
How does it differ from NadReju?
NadReju is a NAD+ (≥98% purity) + PDRN dual formulation in 2.5 mL × 3 vials. AMI NAD+ adds NMN, niacinamide, and adenosine to the NAD+/PDRN base, supplied in 5 mL × 3 vials. Selection depends on whether the practitioner wants a focused dual or a comprehensive multi-active.
What does the niacinamide add?
Niacinamide (Vitamin B3) supports skin barrier function, regulates sebum, and modulates melanin transfer (mild pigmentation effect). At intradermal concentrations, it complements the NAD+/PDRN action by addressing barrier and pigmentation alongside cellular energy and DNA repair.
What does the adenosine add?
Adenosine is a signalling nucleoside with anti-inflammatory and wound-healing effects. In aesthetic use, it supports post-procedure recovery and reduces erythema. Combined with PDRN (which signals through adenosine A2A receptor), there is biological coherence in the formulation.
Is it suitable for the same indications as Puri Heal Revital NAD+?
Yes, with the same core indication: skin energy decline, fatigue-look, mature skin where mitochondrial function is suspected to be limiting. AMI NAD+ additionally addresses barrier and post-procedure recovery indications through its niacinamide/adenosine content.
How is it administered?
Mesotherapy multi-point microinjection (0.05–0.1 mL per point, ~1 cm spacing), or meso-gun delivery, or microchannel post-RF microneedling. Compatible with same-day MTS / microneedling protocols where the product is applied topically through controlled channels.
How many sessions does a typical course require?
3 sessions at 2–3 week intervals is standard. Maintenance every 4–5 months. Some practitioners run longer courses (4–6 sessions) for patients with more pronounced fatigue/energy-deficient presentation.
Does it need cold-chain shipping?
Yes. NAD+ and PDRN are both temperature-sensitive — 2–8 °C refrigerated transit and storage. Single-use only; discard any unused portion after opening the vial. Confirm cold-chain handling on receipt.
Can it be combined with HA filler in the same session?
Yes. Sequential injection at different anatomical levels is the standard approach. Administer AMI NAD+ first in the superficial dermis (mesotherapy plane), then HA filler at deeper levels (subdermal, supraperiosteal, etc.). Avoid mixing in the same syringe.
Are there contraindications?
Standard injectable contraindications: pregnancy and lactation (precautionary), active infection at the treatment site, severe coagulopathy, hypersensitivity to any component. Active malignancy or current chemotherapy: evaluate case-by-case given metabolic/cellular impact of the actives.
David Muller –
As a guy who cares about skincare, I use this product too. Its repair capability is incredibly strong. I previously damaged my skin barrier from over-exfoliating, but after using this with a meso-device, the redness reduced significantly. NAD+ really lives up to the hype; it feels like the cells are activated, and my skin condition is very stable now. Shipping took a few days longer than expected, but the product itself is flawless.