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Rejuran for Acne Scars: How Polynucleotide Therapy Remodels Scar Tissue
Written by FillersFairy Editorial · Reviewed by FillersFairy Clinical Team · Last updated: June 22, 2026
Quick Answer
Rejuran S is the scar-specific variant of the Rejuran polynucleotide line, formulated with higher viscosity PN for direct injection into atrophic acne scars. It works by activating A2A adenosine receptors on fibroblasts, triggering new collagen and elastin production that gradually remodels depressed scar tissue from within. Published case series show reduced scar visibility, improved texture and enhanced skin quality after 2–3 sessions spaced 3 weeks apart. Unlike fillers that physically lift scars, Rejuran S stimulates the skin’s own repair mechanism — the improvement is biological, not mechanical, and continues building after the treatment course.
Why Polynucleotide Works on Acne Scars
Acne scars are areas where the dermis lost collagen during the inflammatory healing process. The body replaced normal skin architecture with disorganised scar tissue — thinner, less elastic, and depressed below the surrounding surface. Standard treatments (laser, microneedling, TCA cross) attempt to stimulate new collagen by creating controlled damage. Rejuran takes a different approach: instead of damaging first and hoping collagen follows, it directly activates the fibroblasts responsible for collagen production.
The mechanism: Once injected into the dermis, Rejuran’s polynucleotide fragments are degraded into nucleotides that bind to adenosine A2A receptors on fibroblasts. This binding triggers a cascade: fibroblast proliferation, increased collagen and elastin synthesis, and production of extracellular matrix components. The result is gradual thickening and reorganisation of the dermal layer beneath the scar — lifting the depression from within rather than filling it from above.
A 2026 case series published in Aesthetic Plastic Surgery (PubMed 42162207) documented clinical improvement in all eight patients treated with Rejuran for scar modulation, including faster re-epithelialisation, reduction of erythema, and narrowing and flattening of scars. A separate survey of Korean cosmetic physicians found that over 88% rated polynucleotide injection as “highly effective” or “effective” for wound healing and skin regeneration.
Which Rejuran Variant? S vs Healer vs I
| Variant | PN Concentration | Viscosity | Designed For |
|---|---|---|---|
| Rejuran S | Higher | High (gel-like) | Acne scars, surgical scars, post-traumatic scars. Higher viscosity allows precise placement into individual scar depressions. |
| Rejuran Healer | Standard | Medium | General skin rejuvenation, fine lines, overall texture. Best for full-face treatment. |
| Rejuran I | Lower | Low (fluid) | Under-eye area, periorbital rejuvenation. Thinner formulation for delicate skin. |
For acne scars, Rejuran S is the correct choice. Its higher viscosity keeps the PN concentrated at the scar site rather than dispersing into surrounding tissue. This is important because scar remodelling requires sustained fibroblast activation directly within the damaged area — a thinner formulation would spread too quickly to deliver sufficient stimulation at the scar base.
Combination approach: Many practitioners use Rejuran S for individual scars and Rejuran Healer for the surrounding skin in the same session. The S targets the depressions; the Healer improves overall texture and tone. This dual approach produces more uniform results than scar-only treatment.
Which Scar Types Respond Best
| Scar Type | Response to Rejuran S | Why |
|---|---|---|
| Rolling scars | Strong | Broad, shallow depressions with intact dermis underneath. The collagen stimulation thickens the dermal layer, pushing the surface upward. |
| Boxcar scars (shallow) | Strong | Well-defined edges with a flat base. Rejuran S fills the base with new collagen, reducing depth. Shallow boxcars respond better than deep ones. |
| Boxcar scars (deep) | Moderate | Deeper depressions may require combination with subcision or filler first, then Rejuran S to remodel the collagen layer. |
| Post-inflammatory texture | Strong | General texture irregularity without deep depressions. Rejuran Healer is often sufficient here; S for focal areas. |
| Ice pick scars | Limited | Narrow, deep, V-shaped scars extend through the dermis. The depth and narrow geometry limits product placement. TCA CROSS or punch excision is typically more effective. |
Treatment Protocol
Standard course for acne scars: 3 sessions spaced 2–3 weeks apart. Published case series used 2 cc of Rejuran S per session with injections placed directly into individual scar bases using a 30-32G needle.
Injection technique: Serial puncture directly into each scar depression, placing a small bolus of Rejuran S at the scar base. The goal is to deliver the PN directly where fibroblast activation is needed — beneath the scar, not in the surrounding normal skin. Follow the manufacturer’s IFU for specific technique guidance.
Assessment timeline: Visible texture improvement typically begins within 4–6 weeks after the first session. Maximum improvement is assessed at 2–3 months after the final session, as collagen remodelling is a gradual process. Before-and-after photography should be standardised (same lighting, angle, distance) at baseline and at each follow-up.
What Results to Expect
What Rejuran S can do: Reduce the depth and visibility of rolling and shallow boxcar scars. Improve overall skin texture and tone around scarred areas. Restore dermal thickness in atrophic regions. Reduce post-inflammatory redness.
What Rejuran S cannot do: Eliminate deep ice pick scars. Replace surgical scar revision for severe scarring. Produce results as dramatic as ablative laser resurfacing. Rejuran S is best positioned as a regenerative complement to other scar treatments, not a standalone solution for severe scarring.
Patient selection matters most. The best candidates have moderate rolling or boxcar scars with some remaining dermal thickness. Patients expecting complete scar elimination from any single treatment will be disappointed — setting this expectation during consultation is essential.
Combination Treatments
Many practitioners combine Rejuran S with other scar treatments for enhanced results:
Rejuran S + Microneedling: Microneedling creates controlled micro-injuries that stimulate healing; Rejuran S provides the biological building blocks for better quality repair. Korean practitioners frequently combine these, with some studies reporting enhanced outcomes versus either treatment alone.
Rejuran S + Subcision: For tethered scars (where fibrous bands anchor the skin down), subcision releases the scar first, then Rejuran S is injected to fill the released space with new collagen rather than letting the scar re-tether.
Rejuran S + Fractional Laser: Laser creates thermal zones that trigger collagen remodelling; Rejuran S accelerates the repair process and supports the quality of new collagen formation.
Practitioner Confidence Summary
Rejuran S addresses acne scars through biological collagen remodelling rather than mechanical filling — the improvement comes from the patient’s own collagen, not from product sitting in the skin. Published case series and Korean practitioner surveys support its efficacy for rolling and boxcar scars. For clinics offering scar treatments, Rejuran S adds a regenerative option that complements existing laser, microneedling and subcision protocols. The 3-session protocol fits naturally into aesthetic treatment schedules, and patients who combine multiple approaches see the strongest results. View Rejuran product details →
Frequently Asked Questions
Does Rejuran actually work on acne scars?
Published case series show clinical improvement in scar visibility, texture and skin quality after Rejuran S treatment. Over 88% of surveyed Korean cosmetic physicians rated polynucleotide injection as effective for wound healing and regeneration. Rejuran S works best on rolling and shallow boxcar scars; deep ice pick scars respond poorly to any injectable treatment.
Which Rejuran is best for acne scars?
Rejuran S — the scar-specific variant with higher viscosity PN that stays concentrated at the injection site. Rejuran Healer is for general skin rejuvenation; Rejuran I is for under-eye treatment. For acne scars, S is the correct product.
How many Rejuran sessions do I need for acne scars?
The standard protocol is 3 sessions spaced 2–3 weeks apart. Published case series used 2 cc per session. Improvement begins within 4–6 weeks and continues building for 2–3 months after the final session as collagen remodelling progresses.
Can Rejuran S be combined with laser for scars?
Yes. Many practitioners combine Rejuran S with microneedling, subcision or fractional laser for enhanced results. Rejuran S supports the quality of collagen repair after controlled skin injury. Schedule the treatments 2–3 weeks apart or follow your treatment provider’s protocol.
Is Rejuran better than fillers for acne scars?
They serve different purposes. HA fillers physically lift individual scars immediately but the effect is temporary (6–18 months). Rejuran S stimulates biological collagen remodelling — results take longer to develop but come from the patient’s own tissue. Many practitioners use both: filler for immediate correction of deep scars, Rejuran S for gradual improvement of overall scar texture.
Related Guides
Disclosure: FillersFairy is a wholesale supplier of Rejuran and other Korean aesthetic products. This article is for educational purposes only and does not constitute medical advice.
References
- Kim M, et al. Polynucleotide (PN) Therapy for Accelerated Wound Repair and Scar Modulation in Aesthetic Procedures. Aesthetic Plast Surg. 2026. PubMed 42162207.
- PharmaResearch. Rejuran product line specifications. pharmaresearch.co.kr.
- Korean cosmetic physician survey on polynucleotide efficacy. Referenced in ResearchGate publications, 2024.
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